Navigation Links
University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels
Date:1/10/2008

There is heartening news out of the University of Alberta for those who may have overindulged during the recent holidays.

U of A medical researchers have found a way to reduce the amount of bad cholesterol and fatty acids that end up in the blood from food the body metabolizes, a key discovery that could lead to new drugs to treat and reverse the effects of Type 2 diabetes and heart disease related to obesity.

In a series of recently published articles,* Dr. Richard Lehner and his colleagues report they successfully decreased the level of LDL (low-density lipids) the so-called bad cholesterol in the blood of mice and hamsters by manipulating a particular enzyme.

Its well-known that eating too much fat and sugar and too little exercise will make you fat, and that obesity often leads to diabetes and heart disease. Lehners group studied the mechanisms behind this.

We established the proof of principle of how these metabolic pathways work, he says. We discovered the activity of an enzyme that releases fatty acids from fat cells and the liver into the blood and how to inhibit this from happening.

Drugs called statins are used to lower LDL levels in patients, but do not treat obesity. What makes the U of A researchers findings noteworthy is their discovery of how to inhibit LDL and triglycerides, which are another form of fat in the blood and a leading risk in obesity-related Type 2 diabetes as well as heart disease.

Lehner is director of the Group on Molecular and Cell Biology of Lipids in the U of As Faculty of Medicine and Dentistry. The research is being supported by the Canadian Institutes of Health Research and the Heart and Stroke Foundation.

Lehner is also a senior scholar for the Alberta Heritage Foundation for Medical Research.

There is a substantial pharmacological interest in the enzymes that control TG (triglycerides fatty acids) and cholesterol metabolism in tissue
'/>"/>

Contact: Julia Necheff
julia.necheff@ualberta.ca
780-492-0437
University of Alberta
Source:Eurekalert

Page: 1 2

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... , August 28, 2015 ... and Training Market by Assessment Type (Pen & Paper ... Brain Training, Corporate Learning, Academic Research), Vertical and Region ... Assessment and Training Market to grow from USD 2.4 ... at a Compound Annual Growth Rate (CAGR) of 25.6% ...
(Date:8/25/2015)... CITY and BELLEVUE, Wash. ... leader in advanced robotic systems, announced today it will ... unmanned ground vehicle (UGV), at the National Tactical Officers ... The Guardian S is the first-ever ... culmination of years of research and in-field trials and ...
(Date:8/24/2015)... 24, 2015  Based on its recent analysis of the ... 2015 African Biometrics Company of the Year Award. DERMALOG is ... success in Africa . It has particularly ... has implemented one of the largest biometric mass applications in ... the Central Bank of Nigeria with ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6
... all terrorist attacks from 1970 to 2008 occurred in just ... rural areas, spurred on by domestic actors, according to a ... the Study of Terrorism and Responses to Terrorism (START), a ... based at the University of Maryland. The research was ...
... Nature Genetics today has found new evidence for ... 2 diabetes. The study found that people who carry rare ... higher risk of type 2 diabetes. The findings should ... could lead to the development of personalised treatments. Previous ...
... Nature Climate Change today finds that tropical vegetation ... Using a combination of remote sensing and field data, scientists ... University of Maryland were able to produce the first "wall-to-wall" ... m) of carbon storage of forests, shrublands, and savannas in ...
Cached Biology News:5 US urban counties lead 'Terror Hot Spots' list, but rural areas not exempt 25 US urban counties lead 'Terror Hot Spots' list, but rural areas not exempt 3Body clock receptor linked to diabetes in new genetic study 2The good news about carbon storage in tropical vegetation 2The good news about carbon storage in tropical vegetation 3
(Date:8/31/2015)... SHANGHAI , Aug. 31, 2015  MicuRx ... antibiotics, today announced positive top-line results from the ... drug candidate MRX-I. MRX-I is an oral oxazolidinone ... MRSA and VRE, while offering physicians and patients ... currently available oxazolidinone agents. "These ...
(Date:8/31/2015)... , Aug. 31, 2015 Trimb Healthcare ... agreement to acquire YouMedical Group BV ("YouMedical"), a Dutch ... has total annual sales of approximately EUR 16 million, ... "Our ambition is to build a ... important step toward that goal. YouMedical gives us a ...
(Date:8/31/2015)... ... August 31, 2015 , ... There’s a new treatment ... is the first commercially available new FDA approved system in the last 14 years, ... 92%, the high Amenorrhea (zero bleeding) rate of 66%, the high Patient Satisfaction rate ...
(Date:8/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/zsgg5n/global_and_usa ) ... USA BioSimilar Market Analysis to 2021" report to ... market will be initiated in September as Sandoz launches ... global market react? Will biosimilars explode into the biologics ... US economy up to $250 billion within the next ...
Breaking Biology Technology:MicuRX Reports Positive Top-Line Results In Phase 2 Clinical Trial For Novel Antibiotic MRX-I In Complicated Skin And Soft Tissue Infections 2U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3
... 28, 2011 Qteros, Inc., the developer of a ... platform for the lowest-cost production of cellulosic ethanol, today ... throughout the month of May. Kevin A. ... for Qteros, will deliver an oral presentation at the ...
... 2011 Omnicare Clinical Research (CR), a leading global, ... has been acquired by Nautic Partners, LLC, a private ... the deal not only makes official the separation of Omnicare ... the company,s most visible step in a comprehensive two-year ...
... April 28, 2011 Reportlinker.com announces that ... in its catalogue: Case ... of biomarker identification and companion diagnostic co-development ... Introduction The ...
Cached Biology Technology:Qteros Management to Present at Upcoming Conferences in May 2Omnicare Clinical Research Acquired by Nautic Partners, LLC 2Omnicare Clinical Research Acquired by Nautic Partners, LLC 3Reportlinker Adds Case Study: Personalized Cancer Therapy - The era of biomarker identification and companion diagnostic co-development 2Reportlinker Adds Case Study: Personalized Cancer Therapy - The era of biomarker identification and companion diagnostic co-development 3
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... VersArray ChipWriter Pro systems are ... proteins, or other biological samples. VersArray ... for uniformity, spot density, and reproducibility ... a variety of substrates. Their modular ...
Thermal printer paper is used with the thermal printer for the VersaFluor fluorometry systems. Supplied as 10 rolls....
Biology Products: