Navigation Links
University awarded £1.7M to develop nanotechnology for use in health care
Date:5/7/2009

Scientists at the University of Liverpool have been awarded 1.7 million to investigate how nanotechnology could be used to improve the effectiveness of pharmaceutical drugs.

Nanotechnology involves the manipulation of matter at sizes close to molecular level to produce particles that are small clusters of molecules. The collaborative project between the Departments of Chemistry and Pharmacology will apply nanotechnology techniques to develop new approaches for future drug development.

Many medicines currently in use have poor solubility and have to be administered in large doses to ensure that enough of the drug is absorbed into the body to be effective. Scientists, working closely with industry experts, will investigate the possibility of creating viable drugs in nanoparticle form each particle being approximately 1/800th the width of a human hair. By examining how successfully they can be absorbed into the intestine, and in what form they pass into the bloodstream, they will also look to establish if nanotechnology can reduce the toxicity of drugs by using smaller doses without losing effect.

The project will focus on the HIV virus the incurable disease that can lead to AIDS. There are more than 20 HIV medicines already on the market, which aim to prevent AIDS by ensuring that the disease cannot replicate uncontrollably in the body. It is important to maintain efficacy while avoiding excessively high or low doses that allow the development of resistance to the drugs. HIV drugs are a lifelong commitment and the doses currently needed have significant associated toxicity when administered over a lifetime. Complications include heart problems, osteoporosis and visible fat redistribution.

Professor Steve Rannard, from the University's Department of Chemistry, said: "Control of matter on this nano-scale is gathering global interest and several new nano-medicines are now commercially available. Our approach will use existing drugs but will focus on changing their size rather than their chemistry. We aim to control their activity and the ability to target the drug to areas where the virus is usually inaccessible.

"Our close collaboration with industry partners and advisors will ensure that we maximise the opportunities available through nanotechnology and, more importantly, that we improve current methods of healthcare for the benefit of patients."

Dr Andrew Owen, from the University's Department of Pharmacology, said: "We aim to improve the activity of currently available drugs but safety is at the forefront of this research, which involves the Medical Research Council Centre for Drug Safety Science.

"We will explore the hypothesis that less medicine is needed in nano-form and hope to prove that creating nano-drugs could enhance their ability to kill the HIV virus while reducing their toxicity. We will look closely at how much of each drug gets into the bloodstream and into different cells and hope to confirm that the nano-medicines are not toxic to their target cells or to the body as a whole."

The three-year project will be undertaken in collaboration with industry partners Astra Zeneca; Merck, Sharpe and Dohm; Gillead; Abbott; and Iota NanoSolutions.

The funding, awarded by Research Councils UK, forms one area of the Nanotechnology Grand Challenges scheme - designed to investigate how nanotechnology could be beneficial to a range of areas such as health, energy and the environment.


'/>"/>

Contact: Laura Johnson
laura.johnson@liv.ac.uk
01-517-942-026
University of Liverpool
Source:Eurekalert

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 , ... ... Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the ... for Excellence in Volunteer Experience from US2020. , US2020’s mission is to change ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation ... Physics and Astronomy, has been selected for membership in ARCS Alumni Hall of ... Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of the ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C ... software to perform Hi-C metagenome deconvolution using their own facilities, supplementing the ...
Breaking Biology Technology: