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University Of Massachusetts Medical School scientists re-imagine how genomes are assembled
Date:11/25/2013

le a particular sequence may fit in many places in a linear genome, we can determine if a particular sequence is a better fit, three dimensionally, in one location versus another, based on this interaction data," said Dr. Kaplan.

With this new approach Kaplan and Dekker were able to predict the positions of 65 previously unlocalized fragments.

"We were surprised how well our method worked," said Kaplan. "It is satisfying to see how a simple idea can solve such a difficult and common problem."

Dekker added, "This new approach to genome assembly can help produce higher-quality genome sequences faster and easier than current methods. It will be especially interesting to apply this method to identify chromosomal aberrations, which are a hallmark of cancer."


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Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert  

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