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Universitat Autonoma de Barcelona researchers first to clone mice in Spain
Date:6/12/2009

ng process. Nuno Costa-Borges, Josep Santal and Elena Ibez are studying whether the use of valproic acid could contribute to an increase in the success rate of nuclear transfer cloning, currently situated at approximately 1% for mice using standard procedures.

Valproic acid is an inhibitor of the enzyme histone deacetylase, located at the cell nucleus where the DNA is found. Research carried out until now has shown that histone deacetylase inhibitors seem to contribute to an increase in levels of gene expression, which would favour the reprogramming of the somatic cell nucleus transferred to the oocyte cytoplasm. Its use in nuclear transfer processes however is very recent. It was first used two years ago and research until now has focused on trichostatin, an inhibitor which has significantly improved the efficiency of mouse cloning, raising it to 5%.

Studies carried out by researchers at UAB can not only be applied to reproductive cloning of animal models; they can also be used for the reprogramming of cells for therapeutic aims.

Costa-Borges, Santal and Ibez are comparing three groups of cloned embryos in their research: valproic acid in the first group, trichostatin in the second and no inhibiting substance in the third group. The three mice in this case were cloned using the first (Cloe and Clona) and second (Cleo) inhibitors. In vitro experiments already pointed to improvements in the development of cloned embryos using inhibitors. However, scientists must wait until the end of the in vivo test period in July to obtain more conclusive data.


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Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

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