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'Universal' vaccines could finally allow for wide-scale flu prevention
Date:2/27/2012

hope to eventually graduate to being able to control the virus' spread and even its evolution," he said. "Our model provides a strong conceptual basis as to how and why the 'universal' vaccines would achieve that."

Arinaminpathy, who works in the lab of co-author Bryan Grenfell, Princeton's Kathryn Briger and Sarah Fenton Professor of Ecology and Evolutionary Biology and Public Affairs, also worked with second author Oliver Ratmann, a postdoctoral associate at Duke University; Katia Koelle, a biology professor at Duke; Suzanne Epstein and Graeme Price of the U.S. Food and Drug Administration; and research scientist Cecile Viboud and physician Mark Miller, both of the National Institutes of Health's Fogarty International Center.

The research presents a realistic and important assessment of how the universal vaccines' ability to work against a breadth of flu strains can be wielded to benefit public health, said James Lloyd-Smith, an assistant professor of ecology and evolutionary biology at the University of California-Los Angeles. Lloyd-Smith had no role in the study, but is familiar with it.

"This is the first study that looks at the population consequences of the next generation of vaccines, both in terms of epidemiological impact and evolutionary impact on the virus," Lloyd-Smith said. "They combined the latest information out of these vaccine trials, and the very latest and best models of influenza virus evolution and epidemiology. They put those together and asked important and relevant questions about how this new vaccine would actually play out.

"They give very clear insights about what the impact of these vaccines would be," he said. "In doing so, this work provides incentive for the vaccine manufacturers to continue this research and development, and it provides some guidance for public health authorities to think about using these new vaccines once they become available."

Arinaminpathy and his colleagues develope
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Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

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