Navigation Links
Unique peptide could treat cancers, neurological disorders, and infectious diseases
Date:2/7/2013

DALLAS Feb. 7, 2013 UT Southwestern Medical Center scientists have synthesized a peptide that shows potential for pharmaceutical development into agents for treating infections, neurodegenerative disorders, and cancer through an ability to induce a cell-recycling process called autophagy.

Autophagy is a fundamental recycling process in which intracellular enzymes digest unneeded and broken parts of the cell into their individual building blocks, which are then reassembled into new parts. The role of autophagy is crucial both in keeping cells healthy and in enabling them to fight different diseases. Physician scientists in UT Southwestern's Center for Autophagy Research are deciphering how to manipulate the autophagy process in an effort to disrupt the progression of disease and promote health.

In their latest findings reported online in the journal Nature, Center researchers were able to synthesize a peptide called Tat-beclin 1, which induces the autophagy process. Mice treated with Tat-beclin-1 were resistant to several infectious diseases, including West Nile virus and another mosquito-borne virus called chikungunya that is common to Asia, Africa, and India. In additional experiments, the team demonstrated that human cells treated with the peptide were resistant to HIV infection in a laboratory setting.

"Because autophagy plays such a crucial role in regulating disease, autophagy-inducing agents such as the Tatbeclin 1 peptide may have potential for pharmaceutical development and the subsequent prevention and treatment of a broad range of human diseases," said Dr. Beth Levine, Director of the Center for Autophagy Research and senior author of the study. Dr. Levine, Professor of Internal Medicine and Microbiology, is a Howard Hughes Medical Institute investigator at UT Southwestern.

Disruption of the autophagy process is implicated in a wide variety of conditions including aging, and diseases, including cancers, neurodegenerative diseases such as Parkinson's and Alzheimer's, and infectious diseases such as those caused by West Nile and HIV viruses.

UT Southwestern has applied for a patent on Tat-beclin-1. Peptides are strings of amino acids found in proteins. The Tat-beclin 1 peptide was derived from sequences in beclin 1, one of the first known proteins in mammals found to be essential for autophagy, a finding that was made by Dr. Levine's laboratory. Her research has since demonstrated that defects in beclin 1 contribute to many types of disease. Conversely, beclin 1 activity and the autophagy pathway appear to be important for protection against breast, lung, and ovarian cancers, as well as for fighting off viral and bacterial infections, and for protecting individuals from neurodegenerative diseases and aging.


'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related biology news :

1. A new pipewort species from a unique, but fragile habitat in India
2. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
3. AGU: Unique microbes found in extreme environment
4. SACLA draws acclaim for unique XFEL design
5. Research reveals unique solution to gene regulation
6. University of Leicester takes delivery of unique eye imaging equipment
7. Concern about plans to close unique Canadian environmental project
8. Rare cliffhanging plant species uses unique reproductive strategy
9. Oil from algae closer to reality through studies by unique collaboration of scientists
10. Iowa State, Ames Lab researchers find 3 unique cell-to-cell bonds
11. Duke Medicine news -- Genome sequencing of Burkitt Lymphoma reveals unique mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... LONDON , February 21, 2017 ... um 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr ... es einige Hindernisse zu überwinden gilt, um diese Prognose ... ... unter anderem die Mobilisierung der finanziellen Mittel für die ...
(Date:2/14/2017)... N.C. , Feb. 14, 2017  Wake Forest ... M.D., as its new chief executive officer (CEO). Freischlag ... CEO John D. McConnell , M.D., who last ... position at the Medical Center, after leading it since ... the full scope of Wake Forest Baptist,s academic health ...
(Date:2/13/2017)... Former 9/11 Commission border counsel and Special ... Kephart of Identity Strategy Partners, LLP, today releases ... "Executive Order: Protecting the Nation From Foreign Terrorist Entry ... "As President Trump,s ,Travel Ban, Executive Order gains more ... the travel ban, it is important that our national ...
Breaking Biology News(10 mins):
(Date:3/20/2017)... ... March 20, 2017 , ... SSCI and Whitehouse Laboratories, ... INTERPHEX 2017 ! Sponsored by the Parenteral Drug Association (PDA), the New ... over 12,000 industry professionals in attendance and more than 625 exhibitors, the educational and ...
(Date:3/20/2017)... ... March 20, 2017 , ... Avexegen Therapeutics Inc., an ... it has entered into an exclusive global license agreement with Children’s Hospital Los ... Enterocolitis (rare orphan disease) as well as Crohn’s Disease and Ulcerative Colitis. ...
(Date:3/20/2017)... ... March 20, 2017 , ... The fourth annual Hackaday Prize ... make an extraordinary impact on peoples’ lives, launches today. Sponsored by Digi-Key ... weeks and awards thousands in cash prizes to engineers, inventors and tinkerers who “build ...
(Date:3/20/2017)... Wash. , March 20, 2017 Western ... provider of ethical review of clinical research, announced today ... Solution TM (SRS) for NIH-funded multi-site research. ... its 2,300 institution clients, WIRB has an extensive background ... our trusted status as the IRB of record for ...
Breaking Biology Technology: