Navigation Links
Unique pattern of gene expression can indicate acetaminophen overdose
Date:10/31/2007

differences in gene expression are linked to specific diseases, the researchers were able to determine which genes were turned on or turned off in response to the different levels of acetaminophen. Once they selected the gene sets, they tested them for accuracy, and found the signature gene lists were able to predict exposure to toxic versus nontoxic doses with very high accuracy (88.9-95.8 percent), while the more traditional predictors, of clinical chemistry, hematology and pathology were approximately 65 to 80 percent accurate.

Although it was not the main focus of our study, we wanted to see how applicable this gene expression profiling of blood cells was to humans, said Raymond W. Tennant, Ph.D., in the NIEHS Laboratory of Molecular Toxicology, and a co-author on the study.

The NIEHS researchers compared the animal data with data from RNA from blood drawn from individuals who had been admitted to the University of North Carolina emergency room for acetaminophen overdose intoxication. When they compared the toxic blood samples to the samples from normal healthy volunteers they saw a striking difference.

Although there are already some good tools available to emergency room physicians to detect liver injury, additional information concerning the level of exposures and/or the degree of liver injury could significantly help us in treating acetaminophen overdose patients, said Paul Watkins, M.D., Director, General Clinical Research Center at the University of North Carolina, Chapel Hill and co-author on the paper.


'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
2. Scientists discover unique microbe in Californias largest lake
3. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
4. Unique library of plant genes germinates, takes root at UNC
5. Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
6. Cultural norms not unique to human societies
7. Jumping genes contribute to the uniqueness of individual brains
8. New, unique microscope for nanotech
9. Computers to save unique type of American red squirrel
10. Uniquely human component of language found in gregarious birds
11. Immune system response to viral DNA is unique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... of cut grass in recent years has been identified ... research says the aroma also summons beneficial insects to ... the plant signals the environment via the emission of ... queue for parasitic wasps to come to the plant ... pest insect," said Dr. Michael Kolomiets, Texas A&M AgriLife ...
(Date:9/22/2014)... that manufacture their own "antifreeze" proteins to survive ... unfortunate side effect, researchers report: The protein-bound ice ... even when temperatures warm. , The finding ... National Academy of Sciences . , "We discovered ... the evolution of antifreeze proteins in Antarctic notothenioid ...
(Date:9/22/2014)... (September 22, 2014) Additive manufacturing (AM), or ... the production of complex-shaped metal components strong enough ... fewer errors and distortions, as well as quality ... kept pace with the technology. Engineers at the ... proposing to develop enhanced modeling and simulation (M&S) ...
Breaking Biology News(10 mins):Mown grass smell sends SOS for help in resisting insect attacks, researchers say 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 3Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3Pitt engineers receive grants to enhance additive manufacturing 2Pitt engineers receive grants to enhance additive manufacturing 3
... Health announced today that it will fund 22 grants ... modifications to genes that result from diet, aging, stress, ... human diseases and biological processes. The awards ... of the NIH Roadmap for Medical Research,s Epigenomics Program. ...
... Prevention Institute at Kansas State University is being honored ... Prevention Roundtable. The K-State institute,s intern program has ... award, also called the MVP2 award, as the best ... Sept. 22, in Washington, D.C. The award is ...
... Calif., September 15, 2009 -- Researchers at the ... that reactive oxygen species, such as superoxide and ... invadopodia, cellular protrusions implicated in cancer cell migration ... director of the Tumor Microenvironment Program at Burnham,s ...
Cached Biology News:NIH funds grantees focusing on epigenomics of human health and disease 2NIH funds grantees focusing on epigenomics of human health and disease 3NIH funds grantees focusing on epigenomics of human health and disease 4K-State Pollution Prevention Institute's intern program named best 2Reactive oxygen's role in metastasis 2
(Date:9/22/2014)... D.C (PRWEB) September 22, 2014 FierceBiotech ... top privately held biotechnology companies of 2014. FierceBiotech ... companies before selecting this year’s winners. Those selected ... biotechnology companies in the industry. , "It's ... new group of Fierce 15 companies," said Carroll. "This ...
(Date:9/22/2014)... 2014  Spherix Incorporated (SPEX) -- an intellectual property development ... today announced that the United States Patent & Trademark Office ... month of September that is part of a standard essential ... USRE45,121 , Application number: US 13/728,867 , ... 27, 2012 The listed inventors of the ...
(Date:9/20/2014)... 20, 2014 HealthTronics, Inc. ... interventional radiology products and services, has signed a ... Clinicon Corporation for its high precision ... of minimally invasive, mobile, surgical technology—offering more choices ... the agreement, HealthTronics will make available Clinicon’s FDA-cleared ...
(Date:9/19/2014)... that use light, rather than electricity, to move ... energy efficiency is a growing concern as chips, ... components of optical circuits light emitters, modulators, ... build. One promising light source for optical chips ... properties when deposited as a single, atom-thick layer. ...
Breaking Biology Technology:FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Toward optical chips 2Toward optical chips 3
... ERT (Nasdaq: ERT ), a ... medial devices to biopharmaceutical and healthcare organizations, announced ... with top tier pharmaceutical companies, totaling over $10 ... business. The company has been selected to provide ...
... 2011 Reportlinker.com announces that a new market research ... Competitor Analysis: Targeted Therapy of Diabetes ... The present Competitive Intelligence Report about Targeted ... field of novel molecules being developed for treatment of ...
... to plasma nanoscience is needed for the world to ... says a leading scientist from CSIRO Materials Science and ... Professor Kostya (Ken) Ostrikov of the Plasma Nanoscience Centre ... IOP Publishing,s Journal of Physics D: Applied Physics ...
Cached Biology Technology:ERT Awarded over $10 Million of ePRO Business from Major Pharma - Increasing its Position as a Leading ePRO Provider 2ERT Awarded over $10 Million of ePRO Business from Major Pharma - Increasing its Position as a Leading ePRO Provider 3Reportlinker Adds Competitor Analysis: Targeted Therapy of Diabetes 2Reportlinker Adds Competitor Analysis: Targeted Therapy of Diabetes 3Plasma nanoscience needed for green energy revolution 2
... the Flp-In System creates isogenic cell ... levels of the protein of interest. ... Figure 3 (click link below). In ... chloramphenicol-acetyl transferase (CAT) was subcloned into ...
... for molecular weight determinations for petroleum-based applications. Multiple solvents can be used, such as water, ... ... ... ...
Fast, sensitive quantitation of total MEK 1/2 concentration....
... and flexibility press-to-seal silicone isolators can be ... researcher. They are available either pre-cut to ... that can be easily trimmed to prepare ... non-cytotoxic and can be used to isolate ...
Biology Products: