Navigation Links
Unique pattern of gene expression can indicate acetaminophen overdose
Date:10/31/2007

differences in gene expression are linked to specific diseases, the researchers were able to determine which genes were turned on or turned off in response to the different levels of acetaminophen. Once they selected the gene sets, they tested them for accuracy, and found the signature gene lists were able to predict exposure to toxic versus nontoxic doses with very high accuracy (88.9-95.8 percent), while the more traditional predictors, of clinical chemistry, hematology and pathology were approximately 65 to 80 percent accurate.

Although it was not the main focus of our study, we wanted to see how applicable this gene expression profiling of blood cells was to humans, said Raymond W. Tennant, Ph.D., in the NIEHS Laboratory of Molecular Toxicology, and a co-author on the study.

The NIEHS researchers compared the animal data with data from RNA from blood drawn from individuals who had been admitted to the University of North Carolina emergency room for acetaminophen overdose intoxication. When they compared the toxic blood samples to the samples from normal healthy volunteers they saw a striking difference.

Although there are already some good tools available to emergency room physicians to detect liver injury, additional information concerning the level of exposures and/or the degree of liver injury could significantly help us in treating acetaminophen overdose patients, said Paul Watkins, M.D., Director, General Clinical Research Center at the University of North Carolina, Chapel Hill and co-author on the paper.


'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
2. Scientists discover unique microbe in Californias largest lake
3. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
4. Unique library of plant genes germinates, takes root at UNC
5. Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
6. Cultural norms not unique to human societies
7. Jumping genes contribute to the uniqueness of individual brains
8. New, unique microscope for nanotech
9. Computers to save unique type of American red squirrel
10. Uniquely human component of language found in gregarious birds
11. Immune system response to viral DNA is unique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... nutrient obtained from milk, fortified cereals and exposure to sunlight, ... blacks, according to a new report by researchers at Johns ... death, killing more than 140,000 Americans annually and temporarily or ... loss of blood flow to the brain. , Researchers say ...
... National Institutes of Health intramural researcher Mortimer Mishkin, Ph.D., ... a White House ceremony later this month. Mishkin ... (NIMH) Section on Cognitive Neuroscience, and acting chief of ... NIMH intramural scientist to receive the medal, which the ...
... November 12, 2010 --Canadian biologist Chris Wood was presented ... The Award was presented by Dr. Philip Campbell, editor-in-chief ... Graduate Studies annual meeting in Toronto earlier this week. ... Society of Canada, is a professor in the Department ...
Cached Biology News:Vitamin D deficit doubles risk of stroke in whites, but not in blacks 2Vitamin D deficit doubles risk of stroke in whites, but not in blacks 3NIMH's Dr. Mortimer Mishkin to be awarded National Medal of Science 2NIMH's Dr. Mortimer Mishkin to be awarded National Medal of Science 3Nature honors outstanding faculty mentor 2
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... care in critical areas, announced the closing of an ... and warrants to purchase up to an aggregate 3,500,000 ... $4.00 per share and $.01 per warrant.  The warrants ... exercisable immediately, and expire 5 years from the date ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ... and share analysis. , Full Copy of ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... December 23, 2014 The ... such as its definition, classification, application and ... specification, manufacturing process, and product cost structure. ... applications. The analysis also covers upstream raw ... industry development trend and proposals. In the ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... new web applications, mashups are creating interesting new sounds, ... combining the soundtracks of one song with the words ... Mashuptown ). , ,On the web, mashups are ... maps, weather, classified listings, or other content linked with ...
... - Ten years from now, when people sit in theaters ... they probably won't think much about the people that helped ... at work as movie-goers take in the last reels of ... in Hollywood. One of them is Jane Durment, CIO for ...
... Mithridion, Inc. , a biopharmaceutical startup that is developing ... $296,800 in federal grants to evaluate tests for drug candidates. ... on Aging , a branch of the U.S. National ... feasibility of the tests. If successful, the company will apply ...
Cached Biology Technology:Would you like your music (and data) mashed? 2Would you like your music (and data) mashed? 3Would you like your music (and data) mashed? 4Would you like your music (and data) mashed? 5CIO Leadership Series: Jane Durment, Marcus Corp. 2CIO Leadership Series: Jane Durment, Marcus Corp. 3CIO Leadership Series: Jane Durment, Marcus Corp. 4Mithridion wins grants for Alzheimer's research 2Mithridion wins grants for Alzheimer's research 3
... Molecular Probes EnzChek Pyrophosphate Detection Kit,provides ... for measuring the inorganic pyrophosphate (PPi ... reactions, such as DNA and,RNA polymerizations, ... cyclase and the enzymatic activation of ...
... high PCR specificity *High PCR specificity ... enzyme with unique QIAGEN PCR Buffer ... provided by the stringent built-in hot ... Master Mix and simple reaction setup ...
Request Info...
... Thermo's Wellwash AC is the ... available, and is provided with liquid ... rinse bottles. The integrated orbital shaker ... guarantee excellent washing performance. The big ...
Biology Products: