Navigation Links
Unique pattern of gene expression can indicate acetaminophen overdose
Date:10/31/2007

differences in gene expression are linked to specific diseases, the researchers were able to determine which genes were turned on or turned off in response to the different levels of acetaminophen. Once they selected the gene sets, they tested them for accuracy, and found the signature gene lists were able to predict exposure to toxic versus nontoxic doses with very high accuracy (88.9-95.8 percent), while the more traditional predictors, of clinical chemistry, hematology and pathology were approximately 65 to 80 percent accurate.

Although it was not the main focus of our study, we wanted to see how applicable this gene expression profiling of blood cells was to humans, said Raymond W. Tennant, Ph.D., in the NIEHS Laboratory of Molecular Toxicology, and a co-author on the study.

The NIEHS researchers compared the animal data with data from RNA from blood drawn from individuals who had been admitted to the University of North Carolina emergency room for acetaminophen overdose intoxication. When they compared the toxic blood samples to the samples from normal healthy volunteers they saw a striking difference.

Although there are already some good tools available to emergency room physicians to detect liver injury, additional information concerning the level of exposures and/or the degree of liver injury could significantly help us in treating acetaminophen overdose patients, said Paul Watkins, M.D., Director, General Clinical Research Center at the University of North Carolina, Chapel Hill and co-author on the paper.


'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
2. Scientists discover unique microbe in Californias largest lake
3. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
4. Unique library of plant genes germinates, takes root at UNC
5. Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
6. Cultural norms not unique to human societies
7. Jumping genes contribute to the uniqueness of individual brains
8. New, unique microscope for nanotech
9. Computers to save unique type of American red squirrel
10. Uniquely human component of language found in gregarious birds
11. Immune system response to viral DNA is unique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... North Carolina , 5. Februar 2015 ... Jahr als spezialisiertes Logistikunternehmen und hat eine ... einzige klinische Logistikfirma (Clinical Logistics Organization – ... der neuen Kampagne lautet First , ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... Conn. , Jan. 26, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... new corporate website ( http://www.nxt-id.com/ ) as part of ... smart wallet. The Company launched its new consumer website ... Gino Pereira , CEO of NXT-ID said, "Our new ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3
... A University of Granada researcher has been awarded the ... Meeting, an international conference of computed microtomography recently celebrated in ... Zoology has been awarded for his biofilm titled Micro-CT anatomical ... the genus Dryops . This film shows from the ...
... of California, Riverside have a "proof of concept" that ... behavior and survival of honey bees. Selenium ... normal development of insects and humans but ... replaces sulfur in amino acids. In soils, particularly ...
... named as the lead university in the United Kingdom ... and engineering., It is the only UK University to ... SWAN Charter awards, which recognise the commitment of institutions, ... gender inequalities and improving career progression for female academics., ...
Cached Biology News:Spanish researcher releases a video showing a beetle from the inside 2Selenium impacts honey bee behavior and survival 2Selenium impacts honey bee behavior and survival 3Queen's is UK leader for female scientists and engineers 2
(Date:2/26/2015)... , Feb. 26, 2015   Regulus Therapeutics ... company leading the discovery and development of innovative medicines ... , Ph.D., President and Chief Executive Officer of Regulus, ... Company 35 th Annual Healthcare Conference on Wednesday, ... is being held at the Boston Marriott Copley Place.  ...
(Date:2/26/2015)... 26, 2015  NuGene International, Inc. ("NuGene") (OTCQB: ... skin and hair rejuvenation, has announced that it ... record for investor relations and strategic communications. ... sales and diversification strategies – and we need ... shareholders," stated Ali Kharazmi CEO of NuGene when ...
(Date:2/26/2015)... 2015 Innovation is more urgent ... unexpected parts of the world and transforming global ... to manufacturing to health care, disruption is constantly ... and socio-political trends shake the foundations of established ... for CEOs to survive the next wave of ...
(Date:2/26/2015)... 2015 Ceres, Inc . today announced ... PartnerNetwork. In attaining Gold Level membership, Ceres has been ... knowledge in delivering Ceres, Persephone genome visualization software and ... Originally developed for in-house use by Ceres, the ... out of massive amounts of genetic data, from a ...
Breaking Biology Technology:Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3One Million Acts of Innovation Canada Creates Partnership with The Economist Events’ Innovation Forum 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4
... Generation Pro-Healing Technology Developments UnveiledSEOUL, South Korea, April ... at a symposium during Angioplasty Summit TCT Asia ... Grande Walkerhill Hotel in Seoul, South Korea. ... Medical Center (AMC), Amsterdam, The Netherlands, final adjudicated ...
... Microtest Laboratories ( www.microtestlabs.com ) ... its position as a proven, one-stop provider of contamination ... for manufacturers of medical devices or pharmaceuticals.Microtest helps manufacturers ... compliance as well as to achieve greater productivity. ...
... Young Companies will Present at the Largest Marketplace for ... NSTI and CTSI today announced that more than 100 ... commercialization partners will be showcased in the 4th Annual ... George R. Brown Convention Center in Houston, Texas. ...
Cached Biology Technology:OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Demonstrates Impressive Results in Higher Risk Patients 2OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Demonstrates Impressive Results in Higher Risk Patients 3Microtest Labs Expands Clean Room, Contamination Testing Services 2Microtest Labs Expands Clean Room, Contamination Testing Services 3Microtest Labs Expands Clean Room, Contamination Testing Services 4TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 2TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 3TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 4
... is a direct antibiotic-based ... identification. Recombinant selection depends ... eliminating the need for ... quick and inexpensive process ...
... has been designed and created in order ... friendly genotyping analysis tool. We incorporated the ... into the software. Their main requirements were ... low acquisition cost. GeneMarker can perform ...
... phase extraction through columns is a well-known ... applications. Typical applications are in DNA/RNA extraction ... or compound purification in chemical or analytical ... on the Genesis series instruments for smaller ...
... 3D structure visualization, phylogenetic tree building, sequence ... single application. Retrieve ... and filter them in real-time Organize ... searching, filtering and sorting Provides up-to-date ...
Biology Products: