Navigation Links
Unique gel capsule structure enables co-delivery of different types of drugs
Date:7/6/2011

Researchers at the Georgia Institute of Technology have designed a multiple-compartment gel capsule that could be used to simultaneously deliver drugs of different types. The researchers used a simple "one-pot" method to prepare the hydrogel capsules, which measure less than one micron.

The capsule's structure -- hollow except for polymer chains tethered to the interior of the shell -- provides spatially-segregated compartments that make it a good candidate for multi-drug encapsulation and release strategies. The microcapsule could be used to simultaneously deliver distinct drugs by filling the core of the capsule with hydrophilic drugs and trapping hydrophobic drugs within nanoparticles assembled from the polymer chains.

"We have demonstrated that we can make a fairly complex multi-component delivery vehicle using a relatively straightforward and scalable synthesis," said L. Andrew Lyon, a professor in the School of Chemistry and Biochemistry at Georgia Tech. "Additional research will need to be conducted to determine how they would best be loaded, delivered and triggered to release the drugs."

Details of the microcapsule synthesis procedure were published online on July 5, 2011 in the journal Macromolecular Rapid Communications.

Lyon and Xiaobo Hu, a former visiting scholar at Georgia Tech, created the microcapsules. As a graduate student at the Research Institute of Materials Science at the South China University of Technology, Hu is co-advised by Lyon and Zhen Tong of the South China University of Technology. Funding for this research was provided to Hu by the China Scholarship Council.

The researchers began the two-step, one-pot synthesis procedure by forming core particles from a temperature-sensitive polymer called poly(N-isopropylacrylamide). To create a dissolvable core, they formed polymer chains from the particles without a cross-linking agent. This resulted in an aggregated collection of polymer
'/>"/>

Contact: Abby Robinson
abby@innovate.gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UA engineering college lands national support for equipment used in unique research
2. Unique gene combinations control tropical maize response to day lengths
3. Through unique eyes, box jellyfish look out to the world above the water
4. Species unique to single island should not be rare there
5. Unique frog helps amphibian conservation efforts
6. Even in a crowd, you remain unique, UCLA life scientists report
7. Single-cell marine predators unique survival mechanisms revealed: UBC research
8. Unique needs and outcomes of pregnant women with breast cancer identified
9. Snakes on a rope: Researchers take a unique look at the climbing abilities of boa constrictors
10. New strain of high-runner rats uniquely resistant to disease -- all disease!
11. Unique database of cancer -- designed to personalize treatment -- is launched
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unique gel capsule structure enables co-delivery of different types of drugs
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market releases photos and ... Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. Verdi ... CEO of NXT-ID thanked his investors and employees "for their work ...
(Date:10/14/2014)... (Oct. 14, 2014)—It,s been millions of years since ... team led by Ohio University scientists is breathing life ... airflow through dinosaur snouts. The research has important implications ... breathe but to enhance the sense of smell and ... animals," said Ohio University doctoral student Jason Bourke, lead ...
(Date:10/14/2014)... CA – October 14, 2014 – Scientists from The ... from the National Institutes of Health (NIH) to lead ... virus-induced hemorrhagic fever disease in Africa. The study aims ... why some patients die, while others survive the inflection. ... understand the basic mechanism of how Lassa fever virus ...
Breaking Biology News(10 mins):Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... paper published today in the journal Science, scientists from ... University Hospital in Reykjavik and Uppsala University in Sweden ... (SNPs) in the sequence of the human genome that ... major subtype of glaucoma. The SNPs are located in ...
... -- Many people with long-standing high blood pressure develop ... and colleagues at Washington University School of Medicine in ... out what could explain that difference. , Their latest ... may underlie heart failure in some hypertensive patients. The ...
... if not deadly. While the desire for these substances can ... important role. The etiology of these desires is multifactorial and ... twin studies have shown that the use of these substances ... that ones sex can influence the genetic factors for alcohol ...
Cached Biology News:deCODE discovers cause of major subtype of glaucoma 2High blood pressure, low energy -- a recipe for heart failure 2Does the desire to consume alcohol and tobacco come from our genetic makeup? 2Does the desire to consume alcohol and tobacco come from our genetic makeup? 3
(Date:10/19/2014)... OCTOBER 20-22, 2014: The ... ABIM will take place at the Congress ... 2014 is now available at http://www.abim.ch ... and organizations from all over the globe ... the latest products and developments on the ...
(Date:10/19/2014)... 2014 The Asian Automatic patient billing ... analysis and forecast of revenue. The Automatic patient billing ... $463.9 million by 2018, at a developing CAGR of ... TOC of the Asian Automatic patient billing market, to ... also provides a glimpse of the segmentation of this ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems report defines and ... of revenue. The Orthopedic braces and support systems market in ... 2018, at a developing CAGR of 4.4% from 2013 to ... braces and support systems market, to get an idea of ... the segmentation of orthopedic braces and support systems market in ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, [Human ... Insulin (Rapid Acting, Long Acting, Premixed)], by Brand ... Forecast to 2018” provides a detailed overview of ... trends, and strategies impacting the global human insulin ... the revenue and share analysis. , The global ...
Breaking Biology Technology:The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... OpGen , a company that makes optical tests ... completed the final stage of its $5 million investment ... of Wisconsin-Madison technology, already sells its testing services to ... split between marketing that service and new developments such ...
... Two weeks ago, we wrote about networking and why ... networking circuit more often. We got mail: Thanks for ... , ,Everyone has to network, we argued, or at ... So heres the corollary: Whether youre unemployed, happily employed ...
... the roads and all the highways. Somehow there are those who ... others drive Ferraris orrace tractor-trailers. To each his own. They are ... brings us to two main points, why is 90 percent of ... the technology marketing increasingly poor? Is it because this highway is ...
Cached Biology Technology:OpGen completes $5 million investment round 2Why and how you should befriend a tech recruiter 2Why and how you should befriend a tech recruiter 3Global Internet branding of technology companies 2Global Internet branding of technology companies 3
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
... have moderate chemiluminescence efficiencies and the chemistry ... have the added benefit that they require ... the background signal. This benefit has been ... immunoassay applications. These compounds can also be ...
Applications: Immunohistochemistry, ISH, FISH, CISH....
... 500 Amplification Kit, 500 reactions. Prepare ... in 4-6 h.Generate microgram quantities of ... starting material.Use amplified DNA directly for ... bacterial or M13 liquid cultures, colonies, ...
Biology Products: