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Unique database of cancer -- designed to personalize treatment -- is launched
Date:10/26/2010

roff, MD, PhD, executive vice president for health sciences at GUMC and executive dean of its School of Medicine, who has championed systems medicine at the University. "It holds promise to enable broad applications on individualized primary prevention."

G-DOC is already being utilized by researchers. As part of a $1 million gift from the Robert M. Fisher Memorial Foundation, information from 200 breast cancer patients treated by Georgetown oncologists has been entered into the G-DOC. The data includes all the "omics" information molecular analysis of genomics, proteomics, metabolomics, methylomics, transcriptomics from tumors, as well as detailed clinical treatment and outcome information and patient questionnaires about their history, lifestyle, and potential risk factors. The Fisher gift also will be used to conduct a prospective trial of the G-DOC approach in women with early-stage breast cancer.

The goal is to understand the biological conditions that lead to a return of cancer in breast cancer patients who had used tamoxifen, so that predictive markers can predict women who may need alternative treatment. Results are already being analyzed.

So far, the G-DOC contains detailed information on a total of 2,953 breast cancer patients who have consented to participate in research.

Another ongoing pilot project at GUMC collects the same kind of detailed information on patients who are newly diagnosed with stage II colorectal cancer to determine the biological characteristics of the 20 percent of patients who are not cured by surgery and so who could benefit from more extensive treatment sooner.

While many researchers collect data on their patients, that information is often not shared. Therefore, G-DOC is unique in two major ways, says Weiner. One is the extensive battery of molecular information that will be collaboratively collected and analyzed, and two, the notion that this information will be directed at answering "
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Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

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