Navigation Links
Unhealthy attachments
Date:2/25/2014

to each other, and then pulled them apart, measuring the strength of the adhesion brought about by the MBP "glue" between the bilayers, and also the MBP's adsorption the ability of the MBP molecules to stick to the bilayers' surfaces. They performed this experiment with both healthy myelin and with "disease-like" myelin bilayers.

"A lipid bilayer simulating a normal or healthy myelin membrane adsorbs this protein much better than a lipid bilayer simulating a multiple sclerosis-type of myelin membrane," said UCSB researcher Kai Kristiansen, "meaning that the protein attaches more strongly to the lipid bilayer and can make two apposing lipid bilayers adhere more firmly to each other and at a smaller distance which is highly desirable for a well functioning myelin around a neuron."

One common characteristic of diseased myelin is swelling, due to various causes such as the autoimmune responses associated with MS and its variants, or in cases of infection or exposure to certain chemicals. Genetics also play a role in the health of myelin.

"When the disease progresses, people can see that they swell and eventually vesiculate, creating scars," said Lee. The MBP layer between the lipid bilayers also swells with water that seeps in between the double lipid layers. Instead of being a compact, molecule-thick film, the MBP layer becomes more gel-like.

"And since there's more water between the bilayers, their insulation property decreases," added Lee. From there, impulses slow down along the axon, or dissipate before they reach their destinations, causing paralysis and loss of function.

Diseaserelated changes in the lipid domain structures' size and distribution also causes irregular adsorption of MBP onto the lipid bilayers and weakens their adhesion properties, leading to lower nerve insulation. This in turn also leads to lower nerve insulation.

The molecular study of healthy and diseased myelin bilayers differs from co
'/>"/>

Contact: Sonia Fernandez
sonia.fernandez@ia.ucsb.edu
805-893-4765
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. TV ads nutritionally unhealthy for kids, study finds
2. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
3. Unhealthy eating can make a bad mood worse
4. Poor mental health leads to unhealthy behaviors among low-income adults
5. Snack attack: Eating unhealthy snack foods may affect cancer risk in patients with Lynch syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unhealthy attachments
(Date:9/30/2014)... know what goes wrong with your muscles because of age, ... "normal" actually is. That,s where a new research report published ... Journal comes in. In the report, a team ... that can help scientists "see" which genes are active in ... never-before-detected gene activity and that men have approximately 400 more ...
(Date:9/30/2014)... MILFORD, Mass. , Sept. 30, 2014 ... process control solutions for the biotech and ... of its new RECONN Bioprocess Manager, an ... reporting solution geared towards bioprocess development laboratories. ... facilities have disparate bioreactor and analyzer systems. ...
(Date:9/30/2014)... Winners of The Economist,s prestigious Innovation awards ... take place at the JW Marriott Hong Kong on Friday, October ... share their experiences and the lessons those hold for others. The ... over the past decade, will be presented at a ceremony in ... It will be the first time the ceremony has come to ...
Breaking Biology News(10 mins):Scientists identify which genes are active in muscles of men and women 2Spectra Automation Introduces RECONN Bioprocess Manager 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7
... study of 18 HIV-positive subjects shows that HIV in the ... that lives in the blood and peripheral tissues. , Moreover, ... the presence of a particular mutation in the HIV envelope ... issue of Brain. It was led by Satish K. Pillai, ...
... is now poised to answer an important and longstanding ... patients have high levels of a brain protein because ... can't clear it from their brains quickly enough? ... at Washington University School of Medicine in St. Louis ...
... on medications such as Ritalin to quell symptoms of ... pinpoint how the drugs work in the brain. , ... now starting to clear up some of the mystery. ... that ADHD drugs primarily target the prefrontal cortex (PFC), ...
Cached Biology News:Viral genetic differences are possible key to HIV dementia 2Viral genetic differences are possible key to HIV dementia 3Production of key Alzheimer's protein monitored for first time in humans 2Production of key Alzheimer's protein monitored for first time in humans 3Study reveals how ADHD drugs work in brain 2Study reveals how ADHD drugs work in brain 3
(Date:10/1/2014)... September 30, 2014 Award winning ... announces four new-hosted collaboration bundles that combine ... high quality conferencing experiences for low, flat rate ... choose from, businesses have optimized solutions to meet ... include audio only minutes (1K, 5K, 10K ...
(Date:10/1/2014)... 2014 Industry leaders from ... engage around the theme, ,Commercial Opportunities in the Era ... Elsevier , a world-leading provider of ... host a gathering of some of the industry,s most ... healthcare today and in the future. The ...
(Date:9/30/2014)... , Sept. 30, 2014 Pacific Northwest ... Summary Global Markets Direct,s, ,Pacific Northwest ... provides an overview of the Pacific Northwest Biotechnology, ... report provides comprehensive information on the current therapeutic ... with comparative analysis at various stages, therapeutics assessment ...
(Date:9/30/2014)... Proove Biosciences , the commercial ... announce a new genetic test built upon research from ... Test will provide physicians with an objective way ... levels are stratified between individuals. With this new test, ... has a genetic predisposition that will affect their pain ...
Breaking Biology Technology:SoundConnect Launches New Audio, Web and Video Bundles 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3
... and phones become computer devices , ,Chances are ... their time on the Internet, thanks to a technology that ... your company isnt already making use of the Internet to ... rather than later. The potential savings and efficiencies are just ...
... MADISON Digital brand-protection company NameProtect has announced ... a way to see if trademarks are showing up in ... sure names they want to use are not already taken, ... ,The companys Search Engine AdTracker, which monitors search-engine ads daily ...
... taken a lot of crap from the academic community for ... the Creative Class. To summarize, Dr. Florida says that a ... economic boomtowns. , ,Some of Richs indexes are controversial. ... of gays, the more likely the city is to be ...
Cached Biology Technology:Calling all computers: VoIP goes mainstream 2Calling all computers: VoIP goes mainstream 3Calling all computers: VoIP goes mainstream 4Calling all computers: VoIP goes mainstream 5Calling all computers: VoIP goes mainstream 6The Creative Class from my perspective 2
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (E6027) or contact customer s...
... pressure gradient system uses three Adept CE ... a flow rate in one microlitre increaments. ... added flexibility. System control and data processing ... interface unit, CE 4900., Column heater/chillers can be ...
... of large numbers of samples may be carried ... minimum operator attention. System control and data ... CE 4900. The elegant, powerful and very ... and Windows 98 and 2000., The supplied detector ...
Biology Products: