Navigation Links
Unhealthy attachments
Date:2/25/2014

to each other, and then pulled them apart, measuring the strength of the adhesion brought about by the MBP "glue" between the bilayers, and also the MBP's adsorption the ability of the MBP molecules to stick to the bilayers' surfaces. They performed this experiment with both healthy myelin and with "disease-like" myelin bilayers.

"A lipid bilayer simulating a normal or healthy myelin membrane adsorbs this protein much better than a lipid bilayer simulating a multiple sclerosis-type of myelin membrane," said UCSB researcher Kai Kristiansen, "meaning that the protein attaches more strongly to the lipid bilayer and can make two apposing lipid bilayers adhere more firmly to each other and at a smaller distance which is highly desirable for a well functioning myelin around a neuron."

One common characteristic of diseased myelin is swelling, due to various causes such as the autoimmune responses associated with MS and its variants, or in cases of infection or exposure to certain chemicals. Genetics also play a role in the health of myelin.

"When the disease progresses, people can see that they swell and eventually vesiculate, creating scars," said Lee. The MBP layer between the lipid bilayers also swells with water that seeps in between the double lipid layers. Instead of being a compact, molecule-thick film, the MBP layer becomes more gel-like.

"And since there's more water between the bilayers, their insulation property decreases," added Lee. From there, impulses slow down along the axon, or dissipate before they reach their destinations, causing paralysis and loss of function.

Diseaserelated changes in the lipid domain structures' size and distribution also causes irregular adsorption of MBP onto the lipid bilayers and weakens their adhesion properties, leading to lower nerve insulation. This in turn also leads to lower nerve insulation.

The molecular study of healthy and diseased myelin bilayers differs from co
'/>"/>

Contact: Sonia Fernandez
sonia.fernandez@ia.ucsb.edu
805-893-4765
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. TV ads nutritionally unhealthy for kids, study finds
2. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
3. Unhealthy eating can make a bad mood worse
4. Poor mental health leads to unhealthy behaviors among low-income adults
5. Snack attack: Eating unhealthy snack foods may affect cancer risk in patients with Lynch syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unhealthy attachments
(Date:9/15/2014)... reef ecologists fears that reef biodiversity may not provide ... once thought. , In an international study published today, ... for Coral Reef Studies (Coral CoE) says we need ... reef ecosystems. , In coral reefs, just as in ... the ecosystem safe and functioning. , Professor Bellwood ...
(Date:9/15/2014)... Sonja Schmid, an assistant professor in the Department of ... Liberal Arts and Human Sciences at Virginia Tech, has ... (CAREER) Award to study the prospects and problems of ... catastrophic failure of Japan,s Fukushima I Nuclear Power Plant ... the scientific community viewed nuclear emergencies, Schmid said. Three ...
(Date:9/15/2014)... agility are hallmarks of the cheetah: The big predator is ... 60 mph in just a few seconds. As it ramps ... tandem, bounding until it reaches a full gallop. , Now ... successfully implemented in a robotic cheetah a sleek, four-legged ... as much as its feline counterpart. The team recently took ...
Breaking Biology News(10 mins):Specialized species critical for reefs 2'Nuclear disasters don't respect national boundaries' 2Run, cheetah, run 2Run, cheetah, run 3
... that every cell in the body contains identical DNA. However, ... has found that genetic variations are widespread in the body,s ... to Yale School of Medicine researchers. Published in ... paves the way for assessing the extent of gene variation, ...
... suggested that a wandering mind indicates unhappiness, whereas a ... Now, a preliminary UCSF study suggests a possible link ... biological measure of longevity. In the study, telomere ... aging, was assessed in association with the tendency to ...
... project to teach undergraduate students about network analysis, turned ... to analyze a National Basketball Association (NBA) basketball team,s ... discovered it is possible to quantify both a team,s ... in an online November issue of PLOS ONE ...
Cached Biology News:Skin cells reveal DNA's genetic mosaic 2Wandering minds associated with aging cells 2Wandering minds associated with aging cells 3Basketball teams offer insights into building strategic networks 2
(Date:9/15/2014)... IRVINE, Calif. , Sept. 15, 2014 /PRNewswire/ ... a new viral transport solution for safe ambient ... prior to molecular testing. Importantly, the infectivity of agents ... solution while maintaining the integrity of the viral ... news of the recent Ebola epidemic in ...
(Date:9/15/2014)... Texas , Sept. 15, 2014 The chemistry, ... in climate, says a new article published by the nonprofit ... , PhD, on climate change and its effects on the ... of an extensive study conducted by Dr. Ahmed in the ... China and has implications for the future of ...
(Date:9/15/2014)... , 15 septembre 2014 La deuxième ... (IPAW) (semaine internationale sur la sensibilisation au ... Initiative conjointe de la Plasma Protein Therapeutics ... membres , l,IPAW vise à : ... de la collecte du plasma-aphérèse , Reconnaître ...
(Date:9/15/2014)... GA (PRWEB) September 15, 2014 ... http://www.hydrodynamics.com ) announced today that it will be ... Estates, CA ( http://www.proteaf.com ) for implementing its ... high value continuous processing. Continuous flow chemistry ... the chemical, pharmaceutical and petrochemical markets for decades. ...
Breaking Biology Technology:Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4L' International Plasma Awareness Week célébrera les donneurs et braquera les projecteurs sur les maladies rares 2L' International Plasma Awareness Week célébrera les donneurs et braquera les projecteurs sur les maladies rares 3Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2
... Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: NTII ), ... from Merz Pharmaceuticals GmbH (Merz) for sales,by ... for the treatment of,moderate-to-severe Alzheimer,s disease during ... exclusive marketing agreement, NTI currently receives,quarterly royalty ...
... evaluation of Botaneco,s technology to add ... functionality to Echium oil ... TSX symbol: SBS, CALGARY, April 30 ... has signed a,feasibility agreement with Croda Enterprise Technology, part of Croda,International Plc, an ...
... /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: AEZS , ... therapy and oncology, today announced that Prof. Frans ... Men,s Health Institutes,in The Netherlands, won the award ... the 23rd Annual European Association of Urology Meeting, ...
Cached Biology Technology:Botaneco signs feasibility agreement with Croda to develop specialty crop oil formulation 2Botaneco signs feasibility agreement with Croda to develop specialty crop oil formulation 3AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 2AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 3AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 4AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 5AEterna Zentaris: Lead Investigator for Cetrorelix Trials in BPH Wins Best Poster Presentation Award at European Association of Urology Meeting in Milan 6
Sheep polyclonal to Melatonin ( Abpromise for all tested applications). Antigen: Melatonin Tg conjugate....
This antibody detects cdc42 on SDS-PAGE immunoblots....
Goat polyclonal to DDDDK tag (FITC) ( Abpromise for all tested applications)....
Rabbit polyclonal to TRPM8 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 79054 SwissProtID: Q3YFM7...
Biology Products: