Navigation Links
Unexpectedly high rate of multiple strains in fungal infection
Date:5/19/2010

New research shows that nearly 1 in 5 cases of infection with the potentially deadly fungus Cryptococcus neoformans are caused by not one but multiple strains of the pathogen. Researchers from the Institut Pasteur and the University of Minnesota Medical School report their findings today in the inaugural issue of mBio, the first online, open-access journal published by the American Society for Microbiology.

"Koch's postulates are criteria establishing a causal relationship between a microbe and a disease that lead to the assumption that the disease is caused by a single strain or its evolved forms," says Franoise Dromer of the Institut Pasteur, an author of the study. "Using molecular analysis of unpurified isolates, we demonstrated that mixed infections in humans are more common than previously thought, occurring in almost 20 percent of patients diagnosed with cryptococcosis."

C. neoformans is a life-threatening fungal pathogen that is responsible for an estimated 1 million cases of meningoencephalitis. It affects up to 30 percent of HIV-infected patients in sub-Saharan Africa and Southeast Asia and despite adequate treatment is still fatal in almost 20 percent of cases.

Cryptococcosis is usually considered to represent the reactivation of a dormant infection. A single isolate of C. neoformans has been thought to be responsible for the disease, but isolation of numerous different strains at the same geographic site suggested infection with multiple stains was possible. Only anecdotal reports of mixed infections have been published to date.

The researchers analyzed clinical cultures collected during a prospective study on cryptococcosis. Using molecular analysis of unpurified isolates they uncovered an unexpectedly high frequency (almost 20 percent) of mixed infections. They further demonstrated that these mixed infections could result from infestation by multiple strains acquired from the environment and that the strains were also evolving during infection.

"The concept of one strain/one infection does not hold true for C neoformans and may apply to other environmentally acquired fungal pathogens. The possibility of mixed and/or evolving infections should be taken into account when developing therapeutic strategies against these pathogens," says Dromer.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Coral reef fish harbor an unexpectedly high biodiversity of parasites
2. Study of placenta unexpectedly leads to cancer gene
3. Salt block unexpectedly stretches in Sandia experiments
4. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
5. Nicotinic receptors may be important targets for treatment of multiple addictions
6. Emphasis on conifer forests places multiple species at risk
7. For honey bee queens, multiple mating makes a difference
8. Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone
9. New magnetic separation technique might detect multiple pathogens at once
10. The power of multiples: Connecting wind farms can make a more reliable - and cheaper - power source
11. Multiple species of bacteria may cause trachoma: Implications for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
(Date:6/22/2016)... June 22, 2016 Research and Markets has ... report to their offering. ... 2014 from $29.3 billion in 2013. The market is expected to ... from 2015 to 2020, increasing from $50.6 billion in 2015 to ... forecasts during the forecast period (2015 to 2020) are discussed. As ...
Breaking Biology Technology: