Navigation Links
Unexpected function of dyslexia gene
Date:6/20/2011

Scientists at Karolinska Institutet in Sweden have discovered that a gene linked to dyslexia has a surprising biological function: it controls cilia, the antenna-like projections that cells use to communicate.

Dyslexia is largely hereditary and linked to a number of genes, the functions of which are, however, largely unknown. This present study from Karolinska Institutet and Helsinki University now shows that one of these genes, DCDC2, is involved in regulating the signalling of cilia in brain neurons.

"Our discovery presents us with a possible new neurobiological mechanism for dyslexia," says Professor Juha Kere, who co-led the study with Professor Eero Castrn of Helsinki University.

Cilia are hair-like structures that project from the surface of most cells. Their purpose has long remained something of a mystery, but recent research has revealed that the cells use them to communicate and that they play a crucial part in the development of the body's organs.

These results tie into previous research in mice showing that DCDC2 and two other dyslexia genes are involved in cell migration, a process by which nerve cells are moved to their correct location in the brain during embryonic development.

"The cilia are important parts of the machinery that controls cell migration," says Professor Kere. "Just what they do and how it could result in dyslexia are interesting questions that will be given further study."

The new findings, which are presented in the scientific journal PLoS ONE show that DCDC2 governs the length of the cilia and activates two different signal systems in the cell, depending on the degree of gene activity. When the human variant of the gene was transferred to nerve cells in the roundworm C. elegans, it gave rise to unusual neural projections exclusively in ciliated cells.

Ciliary dysfunction in different organs has been associated with a wide range of disorders from rare gene
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study of placenta unexpectedly leads to cancer gene
2. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
3. New and unexpected mechanism identified how the brain responds to stress
4. Red pandas reveal an unexpected (artificial) sweet tooth
5. Yeast missing sex genes undergo unexpected sexual reproduction
6. Salt block unexpectedly stretches in Sandia experiments
7. 1-finger exercise reveals unexpected limits to dexterity
8. New study reveals unexpected relationship between climate warming and advancing treelines
9. Study points to new uses, unexpected side effects of already existing drugs
10. Research reveals lipids unexpected role in triggering death of brain cells
11. Study reveals H1N1 unexpected weakness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 2014  Wake Forest Baptist Medical Center today announced plans ... of Medicine. Funding for this $50 million capital project ... be publicly launched next summer. The ... 60 series R.J. Reynolds Tobacco Company complex, adjacent to ... immediately with plans to be ready to welcome medical ...
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
(Date:12/3/2014)... 2, 2014 As part of our commitment ... is pleased to announce the release of a new ... collect the workforce data that they need. ... left by existing readers. Many such devices have serious ... modern technology. Older models force users to navigate numerous ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2
... 2013  Decision Resources, one of the world,s leading research ... that while most of the biomarker-drug success stories are ... development of chronic conditions, and their use in clinical ... Strategic Insights report entitled Driving Drug and ...
... Humans the world over, are hungry for more meat, ... these products has prompted explosive growth in livestock production ... levels. A new textbook, Animal Manure Recycling: Treatment and ... are able to put environmental problems to work and ...
... articles in the biological, life & medical sciences) today announced ... PeerJ PrePrints entirely for free. Previously authors ... one free preprint per year and so this represents a ... been publishing , PeerJ PrePrints, (an innovative pre-print server ...
Cached Biology News:Use of Biomarkers in Clinical Trials for Drugs Outside of Oncology is Increasing 2New textbook tackles the sustainable recycling of manure 2
(Date:12/15/2014)... & PETACH TIKVAH, Israel , Dec. ... BCLI ), a leading developer of adult stem ... subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a grant ... Office of the Chief Scientist (OCS).  This is ... of grant support from the Office of the Chief ...
(Date:12/13/2014)... December 13, 2014 CanDiag, Inc., a ... company has changed its name to OncoTab, Inc. ... of where we are today,” said CEO and Chief ... platform’s applications beyond breast cancer diagnostics to include imaging ... of that evolution.” , Founded in 2011 by Dr. ...
(Date:12/13/2014)... The “Global Synthetic Biology Market (2013-2018)”, ... opportunities, and challenges. , The global synthetic biology ... Thermo Fisher Scientific, Inc. (U.S.), DuPont (U.S.), and ... for approximately ~65% of the total synthetic biology ... This Report @ http://www.marketsandmarkets.com/Market-Reports/synthetic-biology-market-889.html , Thermo ...
(Date:12/13/2014)... , Dec. 12, 2014  Vaccinex ... the discovery and development of therapeutic monoclonal ... today announced publication of a manuscript entitled ... inhibits remyelination in neurodegenerative disease" in the ... of Disease*.  The publication highlights an important ...
Breaking Biology Technology:BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 2Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 3Vaccinex announces publication of preclinical studies with an anti-SEMA4D antibody in animal models of neuroinflammatory and demyelinating disease 2
... clarifies the scope and terms of his settlement with the SEC. ... ... -- Telomolecular, a Rancho Cordova, California Corporation, was formed in 2005 ... of aging and cancer, particularly diseases related to chromosomal telomere shortening. ...
... researchers have synthesized an elusive metal-hydroxide compound in ... way for improved precursor inks that could boost ... to a "bottom-up" production of possibly the first ... nitroso-butylamine as an additive in place of nitrosobenzene. ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced that ... call with,simultaneous webcast to provide a company update on ... Conference Call and Webcast Information, To access the ... minutes prior to the start time and use the,passcode ...
Cached Biology Technology:Former Telomolecular CEO Clarifies SEC Settlement 2Former Telomolecular CEO Clarifies SEC Settlement 3New nanocluster to boost thin films for semiconductors 2Rigel to Host Update Conference Call 2
... be induced prior to DNA purification increasing ... of single-copy BACs with the high yields ... The kits provide the linearized vector and ... system) necessary to create a 10X human ...
... GC content or with significant secondary structure ... when subjected to PCR result in little ... can be increased by the addition of ... is an effective PCR enhancer for GC-rich ...
...
... EPICENTREs patented MasterAmp™ 10X PCR ... performance and allows improved sensitivity and ... templates. Using MasterAmp PCR Enhancer in ... of DNA melting, increases enzyme?s thermal ...
Biology Products: