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Unexpected findings of lead exposure may lead to treating blindness
Date:10/25/2010

g gestation caused cells to proliferate, increased neurons and did not affect glia," Fox said. "So, gestational exposure produces an exact opposite to what was previously shown by our lab and others. It also shows that the timing of chemical exposure during development is just as important as the amount of exposure."

This brought the researchers to a crossroads. On the one hand, the retina is not built to have all these extra cells and, according to unpublished data from Fox's mouse studies, the retinas will start to degenerate as the mice age. This suggests that the retinas of the children from the original Mexico City study should be examined as they might start to degenerate when they are 40 years of age.

"This work has long-term implications in retinal degeneration and diseases where photoreceptors die. If we can figure out how low-level lead increases the number of retinal progenitor cells and selectively produces photoreceptors and bipolar cells, then perhaps a drug can be created to help those with degenerative retinal diseases that eventually cause blindness," Fox said. "Researchers may be able to use lead as tool in transforming embryonic retinal stem cells into rods and bipolar cells that could be transplanted into diseased retinas, ultimately saving sight and reversing blindness."

Fox said that more research is needed before such a potential drug could be developed to mimic the effects of lead. Ideally, this drug would induce human embryonic retinal stem cells to form rods and bipolars that could be transplanted into patients to treat early stages of retinal degeneration.


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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

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