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Understanding why some people have propensity to disease
Date:5/14/2012

erize both types of SNPs to help predict disease susceptibility and response to drug treatments. Such a characterization will help lay the foundation for personalized medicine, ultimately leading to more effective and hence less costly health care costs."

Sladek's lab will use a powerful new technology, called protein binding microarrays, to identify SNPs in DNA sequences to which nuclear receptors bind. By integrating a range of biochemical, molecular, genomic and bioinformatics approach, the researchers will examine nuclear-receptor-DNA binding and how SNPs influence it.

The team will make publicly available all their results on a UC Riverside website dedicated to the project, as well as on other public databases. The researchers are also developing web-based tools for target gene prediction, an evolving science of efficiently identifying the regions of genomic DNA that regulate the expression of genes.

"We hope these tools will advance the long-term goal of fast-tracking research linking nuclear receptors to disease and drug metabolism, and thereby help personalize medicine and ensure that drugs that target nuclear receptors can be used in a more effective fashion," Sladek said.

DNA, situated in the cell's nucleus, carries the genetic information of a cell and consists of thousands of genes. Each gene serves as a recipe on how to build a protein molecule. Proteins perform important tasks for the cell functions or serve as building blocks. When proteins are needed, the corresponding genes are made into RNA (single-stranded molecules that can adopt very complex three-dimensional structures) via a process called transcription for which proteins, called transcription factors, are needed. Nuclear receptors are transcription factors that regulate the expression of a wide range of genes involved in nearly all aspects of human phys
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Contact: Iqbal Pittalwala
951-827-6050
University of California - Riverside
Source:Eurekalert  

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