Navigation Links
Understanding why some people have propensity to disease
Date:5/14/2012

RIVERSIDE, Calif. Aside from identical twins, no two individuals are completely identical genetically. Most differences between individuals are due to single nucleotide changes or polymorphisms (SNPs) DNA sequence variations in the genome.

SNPs, the most common type of genetic variation among people, are being increasingly recognized as playing a major role in phenotype variations, such as eye and hair color, basal body weight, muscle tone, responsiveness to alcohol consumption, as well as susceptibility to diseases such as cancer, diabetes, heart disease and mental disorders.

The more scientists know what SNPs' functions are, the easier it would be to understand the tremendous variability in individuals' responses to drug treatments such as why some drugs are life-saving for some people but cause serious side effects in others.

Frances Sladek, a professor of cell biology and toxicologist at the University of California, Riverside, has received a $1.5 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health to support a four-year research project that will allow her to examine the effect SNPs have on a special class of proteins called nuclear receptors that bind DNA and regulate the expression of many important genes in response to hormones, vitamins and drugs.

"Many SNPs introduce structural or functional changes in the proteins encoded by genes," explained Sladek, the grant's principal investigator. "Other SNPs, the vast majority, are outside of the protein-coding portion of the gene; they are often found in the regulatory regions of genes regions that determine the level of gene expression. We will charact
'/>"/>

Contact: Iqbal Pittalwala
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New data improve understanding of breast cancers multiple varieties
2. New genetically engineered mice aid understanding of incurable neuromuscular disease
3. Study amplifies understanding of hearing in baleen whales
4. Understanding and treating the cognitive dysfunction of Down syndrome and Alzheimers disease
5. A breakthrough in understanding the biology and treatment of ovarian cancer
6. Understanding how bacteria come back from the dead
7. Shane Ross garners CAREER Award to advance understanding of fluid flows from blood inside the body to oil spills in bodies of water
8. Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
9. Understanding causes of obesity in Aboriginal children
10. Scripps Research scientists provide new understanding of chronic pain
11. A firmer understanding of muscle fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Understanding why some people have propensity to disease
(Date:4/17/2014)... in many serious conditions such as heart disease, epilepsy ... drug therapies. Unfortunately, there is still much scientists do ... fresh and unexpected insight into the structure of sodium ... molecules - which are responsible for ,fine-tuning, the activity ... most recent edition of the Journal of Biological ...
(Date:4/17/2014)... Current Biology on April 17 have discovered ... Brazilian insects, which represent four distinct but related species ... example of an animal with sex-reversed genitalia. , ... animals, Neotrogla is the only example in ... Yoshizawa from Hokkaido University in Japan. , During copulation, ...
(Date:4/17/2014)... whereby the genetic information of DNA is used ... have numerous different functions in living organisms. Messenger ... gene expression, by relating the genetic information of ... proteins. , By examining the different types ... organism at a given time, researchers can determine ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2In sex-reversed cave insects, females have the penises 2Rapid and accurate mRNA detection in plant tissues 2
... traced the origin of Plasmodium vivax , the second-worst ... published this week in Nature Communications . Until recently, ... were found only in Asian macaques, leading researchers to believe ... The study, led by researchers from the Perelman School of ...
... DNA sequencing technologies have enormous potential for the ... these new technologies, researchers are able to greatly ... key to applications including plant breeding and physiology. ... (or phylogenetic) relationships among different plant species have ...
... a spectrum of signals from hormones within a plant. ... in the roots of plants, and their journey to ... plant development. Though these phytohormones have been identified in ... within plants was previously poorly understood. Now, a ...
Cached Biology News:The parasite that escaped out of Africa 2The parasite that escaped out of Africa 3The parasite that escaped out of Africa 4Sequencing hundreds of nuclear genes in the sunflower family now possible 2Sequencing hundreds of nuclear genes in the sunflower family now possible 3Roots to shoots: Hormone transport in plants deciphered 2
(Date:1/14/2014)... 14, 2014 The largest international professional organization ... and therapeutic derivatives thereof has endorsed an educational ... about the challenges of adulterated herb and botanical ... The Society for Medicinal Plant and ...
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
(Date:1/14/2014)... OTTAWA, Ontario , Jan. 14, 2014   Kinaxis ®, ... ( SCM ) and sales and operations planning ( S&OP ... the Biomanufacturing Summit , which will be held at ...  At the conference, join Kinaxis customer Elisabeth Kaszas , ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Reflects Full Scope of Integrated Global Services, ... Clinical,Trials today launches under a new name, Abt ... Associates Inc. The company will continue to,provide custom ... medical device and diagnostics industries,utilizing a team approach ...
... OF PRUSSIA, Pa., April 1, 2008 HighPoint Solutions,LLC, ... it,has been selected by a global biotechnology company to ... prepare for the company,s new,product launches and support its ... science companies continue to strive to create a holistic ...
... Increases 60% to $87.1 Million ... Increases 61% to $8.6 Million, XIAN, China, April ... Board: CBEH), (CBEH or the "Company"), an,energy company engaged ... finished oil products and the development, production and,distribution of ...
Cached Biology Technology:Abt Associates Clinical Trials Announces Name Change to Abt Bio-Pharma Solutions, Inc. 2HighPoint Solutions Selected by Global Biotechnology Company to Provide Master Data Management Solution 2China Bio Energy Reports Fiscal 2007 Financial Results 2China Bio Energy Reports Fiscal 2007 Financial Results 3China Bio Energy Reports Fiscal 2007 Financial Results 4China Bio Energy Reports Fiscal 2007 Financial Results 5China Bio Energy Reports Fiscal 2007 Financial Results 6China Bio Energy Reports Fiscal 2007 Financial Results 7China Bio Energy Reports Fiscal 2007 Financial Results 8China Bio Energy Reports Fiscal 2007 Financial Results 9China Bio Energy Reports Fiscal 2007 Financial Results 10China Bio Energy Reports Fiscal 2007 Financial Results 11
This kit only detects beta-galactosidase activity at pH 6 in cultured cells andtissue sections. Beta-galactosidase activity at pH 6 ispresent only in senescent cells, and is not found inpresenescent...
... OS X provides the most highly integrated ... analysis and molecular biology data management available ... Suite you can store manage view analyze ... molecular biology data all within one integrated ...
SHEEP ANTI BOVINE LACTOPEROXIDASE...
Growth Medium / Media...
Biology Products: