Navigation Links
Understanding the biological and ecological implications of safe nanotechnology

Nanoscale science and technology has seen exciting advances recently in drug delivery, electronics, energy and environmental applications. According to international scientific conventions, nanomaterials are those whose at least one dimension is less than or equal to 10-9 m. At the same time, there is a great possibility for nanomaterials to enter ecosystems at the points of use or disposal, which could lead to negative environmental implications.

Our recent paper, "Dendrimer-fullerenol soft-condensed nanoassembly" published in The Journal of Physical Chemistry C, showed how the soft nanomaterial dendrimer can be used to remediate the environment from potentially toxic nanomaterials. Here, we used fullerenol a 60 carbon molecule in the shape of a buckyball and functionalized with hydroxyl groups as a model system. Such an assembly also has implications for drug delivery.

We found that the assemblies of dendrimers and fullerenols were strong, spontaneous, and thermodynamically favorable at neutral water pH and ambient temperature and pressure.

Dendrimers are highly branched, polymeric macromolecules with a high degree of surface functionalities. Their branching determines their generation number (G) the higher the generation, the greater the degree of surface functionalities. We used both G1 and G4 poly(amidoamine) (PAMAM) dendrimers and found that both these dendrimers hosted one fullerenol per primary amine on the dendrimer surfaces. However, G4 PAMAM dendrimers hosted fullerenols 40 times better than G1, simply because of their higher degree of surface functionalities. Based on our findings, we recommended proper loading capacities of fullerenols for G1 and G4 dendrimers in drug delivery and environmental remediation.

With the advent of new technologies, the public often becomes skeptical of their implications on the environment. In our group, we strive to understand the biological and ecological implications of safe nanotechnology. This article was a part of that effort. Fullerenols have shown great potential in nanomedicine as well as in electronics. Dendrimers of generations five and below have been proven biocompatible, and have been used as MRI contrast agents and drug delivery vehicles. In this paper we provided a proof-of-concept on the use of a benign dendritic technology as a robust drug delivery vehicle and a solution to environmental remediation of discharged nanomaterials.

Our group, led by my advisor Dr. Pu-Chun Ke and funded by the National Science Foundation, has delved into a crucial topic of frontier research termed "nanoparticle-protein corona". In short, nanoparticles do not interact directly with living systems but are often coated with biological fluids in the form of a protein corona. Another direction in our group, through collaboration between Dr. Ke and Dr. David Ladner in Clemson's Department of Environmental Engineering and Earth Sciences and funded by the U.S. Environmental Protection Agency is to employ dendritic polymers for remediating oil spills.

Contact: Brian Mullen
Clemson University

Related biology news :

1. Joslin researchers gain new understanding of diabetes and kidney disease
2. Stem cell research aids understanding of cancer
3. Discovery increases understanding how bacteria spread: U of A study
4. Understanding faults and volcanics, plus life inside a rock
5. New understanding of terrestrial formation has significant and far reaching future implications
6. A trained palate: Understanding complexities of taste, smell could lead to improved diet
7. Zebrafish could hold the key to understanding psychiatric disorders
8. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
9. Understanding why some people have propensity to disease
10. New data improve understanding of breast cancers multiple varieties
11. New genetically engineered mice aid understanding of incurable neuromuscular disease
Post Your Comments:
Related Image:
Understanding the biological and ecological implications of safe nanotechnology
(Date:11/12/2015)...  Arxspan has entered into an agreement with ... use of its ArxLab cloud-based suite of biological ... will support the institute,s efforts to electronically manage ... internally and with external collaborators. The ArxLab suite ... Institute,s electronic laboratory notebook, compound and assay registration, ...
(Date:11/10/2015)... , Nov. 10, 2015  In this ... the basis of product, type, application, disease ... in this report are consumables, services, software. ... are safety biomarkers, efficacy biomarkers, and validation ... report are diagnostics development, drug discovery and ...
(Date:11/9/2015)...  Synaptics Inc. (NASDAQ: SYNA ), the leading ... into the automotive market with a comprehensive and dedicated ... consumer electronics human interface innovation. Synaptics, industry-leading touch controllers, ... automotive industry and will be implemented in numerous locations ... , Japan , and ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015  PharmAthene, Inc. (NYSE MKT: PIP) announced  today ... rights plan (Rights Plan) in an effort to preserve ... under Section 382 of the Internal Revenue Code (Code). ... use of its NOLs could be substantially limited if ... Section 382 of the Code. In general, an ownership ...
(Date:11/25/2015)... 2015  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... CEO of Neurocrine Biosciences, will be presenting at the ... New York . .   ... 5 minutes prior to the presentation to download or ... will be available on the website approximately one hour ...
(Date:11/25/2015)... 2015 The Global Genomics ... professional and in-depth study on the current state ... ) , The report ... definitions, classifications, applications and industry chain structure. The ... markets including development trends, competitive landscape analysis, and ...
(Date:11/24/2015)... Calif. , Nov. 24, 2015 Cepheid ... will be speaking at the following conference, and invited ... New York, NY      Tuesday, December 1, 2015 ... New York, NY      Tuesday, December 1, 2015 ... Jaffray Healthcare Conference, New York, NY ...
Breaking Biology Technology: