Navigation Links
Understanding the biological and ecological implications of safe nanotechnology
Date:8/6/2012

Nanoscale science and technology has seen exciting advances recently in drug delivery, electronics, energy and environmental applications. According to international scientific conventions, nanomaterials are those whose at least one dimension is less than or equal to 10-9 m. At the same time, there is a great possibility for nanomaterials to enter ecosystems at the points of use or disposal, which could lead to negative environmental implications.

Our recent paper, "Dendrimer-fullerenol soft-condensed nanoassembly" published in The Journal of Physical Chemistry C, showed how the soft nanomaterial dendrimer can be used to remediate the environment from potentially toxic nanomaterials. Here, we used fullerenol a 60 carbon molecule in the shape of a buckyball and functionalized with hydroxyl groups as a model system. Such an assembly also has implications for drug delivery.

We found that the assemblies of dendrimers and fullerenols were strong, spontaneous, and thermodynamically favorable at neutral water pH and ambient temperature and pressure.

Dendrimers are highly branched, polymeric macromolecules with a high degree of surface functionalities. Their branching determines their generation number (G) the higher the generation, the greater the degree of surface functionalities. We used both G1 and G4 poly(amidoamine) (PAMAM) dendrimers and found that both these dendrimers hosted one fullerenol per primary amine on the dendrimer surfaces. However, G4 PAMAM dendrimers hosted fullerenols 40 times better than G1, simply because of their higher degree of surface functionalities. Based on our findings, we recommended proper loading capacities of fullerenols for G1 and G4 dendrimers in drug delivery and environmental remediation.

With the advent of new technologies, the public often becomes skeptical of their implications on the environment. In our group, we strive to understand the biological and ecological implications of safe nanotechnology. This article was a part of that effort. Fullerenols have shown great potential in nanomedicine as well as in electronics. Dendrimers of generations five and below have been proven biocompatible, and have been used as MRI contrast agents and drug delivery vehicles. In this paper we provided a proof-of-concept on the use of a benign dendritic technology as a robust drug delivery vehicle and a solution to environmental remediation of discharged nanomaterials.

Our group, led by my advisor Dr. Pu-Chun Ke and funded by the National Science Foundation, has delved into a crucial topic of frontier research termed "nanoparticle-protein corona". In short, nanoparticles do not interact directly with living systems but are often coated with biological fluids in the form of a protein corona. Another direction in our group, through collaboration between Dr. Ke and Dr. David Ladner in Clemson's Department of Environmental Engineering and Earth Sciences and funded by the U.S. Environmental Protection Agency is to employ dendritic polymers for remediating oil spills.


'/>"/>
Contact: Brian Mullen
mullen2@clemson.edu
864-656-2063
Clemson University
Source:Eurekalert  

Related biology news :

1. Joslin researchers gain new understanding of diabetes and kidney disease
2. Stem cell research aids understanding of cancer
3. Discovery increases understanding how bacteria spread: U of A study
4. Understanding faults and volcanics, plus life inside a rock
5. New understanding of terrestrial formation has significant and far reaching future implications
6. A trained palate: Understanding complexities of taste, smell could lead to improved diet
7. Zebrafish could hold the key to understanding psychiatric disorders
8. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
9. Understanding why some people have propensity to disease
10. New data improve understanding of breast cancers multiple varieties
11. New genetically engineered mice aid understanding of incurable neuromuscular disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Understanding the biological and ecological implications of safe nanotechnology
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer experts from Austria, Hungary, ... be a new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has ... it now. , Biomarkers are components in the blood, tissue or body ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... Amgen, will join the faculty of the University of North Carolina Kenan-Flagler ... of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s ...
(Date:6/24/2016)... TOKYO , June 24, 2016  Regular discussions on ... to take place between the two entities said Poloz. ... in Ottawa , he pointed to the ... and the federal government. ... Poloz said, "Both institutions have common economic goals, why not ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
Breaking Biology Technology: