Navigation Links
Understanding the biological and ecological implications of safe nanotechnology
Date:8/6/2012

Nanoscale science and technology has seen exciting advances recently in drug delivery, electronics, energy and environmental applications. According to international scientific conventions, nanomaterials are those whose at least one dimension is less than or equal to 10-9 m. At the same time, there is a great possibility for nanomaterials to enter ecosystems at the points of use or disposal, which could lead to negative environmental implications.

Our recent paper, "Dendrimer-fullerenol soft-condensed nanoassembly" published in The Journal of Physical Chemistry C, showed how the soft nanomaterial dendrimer can be used to remediate the environment from potentially toxic nanomaterials. Here, we used fullerenol a 60 carbon molecule in the shape of a buckyball and functionalized with hydroxyl groups as a model system. Such an assembly also has implications for drug delivery.

We found that the assemblies of dendrimers and fullerenols were strong, spontaneous, and thermodynamically favorable at neutral water pH and ambient temperature and pressure.

Dendrimers are highly branched, polymeric macromolecules with a high degree of surface functionalities. Their branching determines their generation number (G) the higher the generation, the greater the degree of surface functionalities. We used both G1 and G4 poly(amidoamine) (PAMAM) dendrimers and found that both these dendrimers hosted one fullerenol per primary amine on the dendrimer surfaces. However, G4 PAMAM dendrimers hosted fullerenols 40 times better than G1, simply because of their higher degree of surface functionalities. Based on our findings, we recommended proper loading capacities of fullerenols for G1 and G4 dendrimers in drug delivery and environmental remediation.

With the advent of new technologies, the public often becomes skeptical of their implications on the environment. In our group, we strive to understand the biological and ecological implications
'/>"/>

Contact: Brian Mullen
mullen2@clemson.edu
864-656-2063
Clemson University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Joslin researchers gain new understanding of diabetes and kidney disease
2. Stem cell research aids understanding of cancer
3. Discovery increases understanding how bacteria spread: U of A study
4. Understanding faults and volcanics, plus life inside a rock
5. New understanding of terrestrial formation has significant and far reaching future implications
6. A trained palate: Understanding complexities of taste, smell could lead to improved diet
7. Zebrafish could hold the key to understanding psychiatric disorders
8. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
9. Understanding why some people have propensity to disease
10. New data improve understanding of breast cancers multiple varieties
11. New genetically engineered mice aid understanding of incurable neuromuscular disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Understanding the biological and ecological implications of safe nanotechnology
(Date:9/2/2014)... Yale Cancer Center researchers may have discovered a ... cells made vulnerable by deficient DNA repair. , The ... Reports . , The study, led by James ... Yale School of Medicine, found that cancer cells with ... their own genetic damage) were significantly more vulnerable to ...
(Date:9/2/2014)... digital distribution of media will have lower carbon ... when file sizes are large. , That,s the ... Journal of Industrial Ecology that looked at ... as PlayStation3. Researchers found that Blu-ray Discs delivered ... than game files downloaded over broadband Internet. For ...
(Date:9/2/2014)... 2, 2014 In a new study that could ... Florida campus of The Scripps Research Institute (TSRI) have ... unique manufacturing sites for molecules that can treat a ... as a reaction vessel and a disease-causing defect as ... cell," said TSRI Professor Matthew Disney.,"Because the treatment is ...
Breaking Biology News(10 mins):Sabotage as therapy: Aiming lupus antibodies at vulnerable cancer cells 2Scripps Florida scientists make diseased cells synthesize their own drug 2
... pathogens rather than kill them, and although they could be ... humans. A new study to be published in the online ... drugs have the potential to fight infection while avoiding the ... kill or stop the growth of pathogens, but antivirulence drugs ...
... Diego School of Medicine say that losing the ability to ... in early hominids, and may have directed the evolutionary emergence ... findings, published in this week,s early online edition of the ... among the first evidence of a novel link between cell ...
... York and Hull York Medical School has revealed important ... by age. Working with scientists at the Peninsula ... studied responses to stress in synapses -- neuronal connections. ... such as neuro-degeneration, resulting high energy forms of damaging ...
Cached Biology News:Can antivirulence drugs stop infections without causing resistance? 2Sexual selection by sugar molecule helped determine human origins 2Sexual selection by sugar molecule helped determine human origins 3Researchers study aging's effect on the brain 2
(Date:9/2/2014)... critical, yet often overlooked factor in the medical ... effects of aggregation on both radiofrequency heating and ... oxide nanoparticles (IONPs), including detailed analysis of the ... is shown to produce significant reductions in both ... new method to quantify and correlate these effects ...
(Date:9/2/2014)... including University of Oregon chemist Geraldine Richmond, have ... self-assembling, synthetic proteins called peptoid nanosheets that mimic ... -- detailed this week in a paper placed ... of the National Academy of Sciences -- ... the two-dimensional peptoid nanosheets that can be used ...
(Date:9/2/2014)... , Sept. 2, 2014  TransCelerate BioPharma Inc. ... recommended approach for protecting personal data in Clinical ... patients and others. The document describes an approach ... from CSRs and other related clinical trial documents, ... The goal of the TransCelerate CSR Redaction approach ...
(Date:9/2/2014)... Opertech Bio, Inc., a company ... effective approach to sensory evaluation, today announced the ... U.S. Patent and Trademark Office, encompassing high-throughput sensory ... “Opertech’s taste evaluation technology called Microtiter Operant Gustometer ... system for rapid characterization of taste sensory properties,” ...
Breaking Biology Technology:Accounting for biological aggregation in heating and imaging of magnetic nanoparticles 2UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 3Opertech Bio Receives U.S. Patent for High-Throughput Taste Evaluation Technology 2
... Randomized Study Under Consideration, ROCKVILLE, Md., Nov. ... clinical-stage pharmaceutical company developing,therapeutics for the treatment of ... met the primary endpoint for the efficacy portion ... in combination with pemetrexed,(Alimta(R)) in non-small cell lung ...
... update on business and product pipeline, BOTHELL, ... Inc. (NASDAQ: OGXI ), a biopharmaceutical company ... that address,unmet needs in the treatment of cancer, ... and nine months ended September 30, 2008., ...
... 10 /Xinhua-PRNewswire/ -- Simcere Pharmaceutical,Group (NYSE: SCR ... generic,pharmaceuticals and innovative anti-cancer pharmaceuticals in the rapidly,growing ... Morgan,Stanley 7th Annual Asia Pacific Summit 2008. The ... on November 11-13, 2008., Simcere,s chief financial ...
Cached Biology Technology:EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial 2EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial 3OncoGenex Reports Third Quarter Financial Results 2OncoGenex Reports Third Quarter Financial Results 3OncoGenex Reports Third Quarter Financial Results 4OncoGenex Reports Third Quarter Financial Results 5OncoGenex Reports Third Quarter Financial Results 6OncoGenex Reports Third Quarter Financial Results 7OncoGenex Reports Third Quarter Financial Results 8OncoGenex Reports Third Quarter Financial Results 9Simcere Pharmaceutical Group to Participate in Morgan Stanley Seventh Annual Asia Pacific Summit 2008 2
...
solute carrier family 25, member 13 (citrin)...
... Ladder is suitable for sizing ... 16 kb by agarose gel ... be visualized by ethidium bromide ... detected on Southern blots by ...
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: