Navigation Links
Understanding how oxidative stress impairs endothelial progenitor cell function
Date:11/25/2008

INDIANAPOLIS Although its been over a decade since endothelial progenitor cells or EPCs, cells that circulate in the blood repairing and replacing the cells that line blood vessels, were identified, the field is still evolving. EPCs are now being studied as biomarkers to assess the risk of future cardiovascular disease and as potential agents for vascular regeneration.

Researchers from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine and Riley Hospital for Children report in the November 2008 issue of the journal Antioxidants & Redox Signaling that a review of the scientific literature reveals that how EPCs respond to oxidantive stress appears to be a critical determinant in maintaining a healthy cardiovascular system.

A comprehensive understanding of how oxidantive stress, the biochemical modification of cells, impairs EPC function may lead to antioxidant therapy to prevent disease.

"The study of EPCs is exciting because as the work evolves it should enable us to develop clinical strategies to decrease the risk of heart attack or stroke by reversing oxidative stress at the cellular level," said study author Laura Haneline, M.D., associate professor of pediatrics at the IU School of Medicine. "These strategies will need to be applied early in the disease when preventing oxidative damage is a possibility because once the damage has occurred it may not be reversible."

High cholesterol causes increased oxidative stress, impairing the function of EPCs. In addition to being implicated in cardiovascular diseases, oxidative stress is also a factor in diabetes.

"Further studies of how oxidative stress impairs the function of EPCs are critical. Eventually you should be able to get a simple blood test measuring your EPCs to see if you are at risk for disease. With this knowledge, in the not too distant future, we should be able to apply antioxidant therapies to prevent that disease," said Dr. Haneline.

In the meantime studies that examine the impact of oxidative stress on specific functions of the EPCs are needed to fully understand the progression of vascular disease.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-247-7722
Indiana University
Source:Eurekalert  

Related biology news :

1. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
2. Proteins in sperm unlock understanding of male infertility says new study
3. Hidden infections crucial to understanding, controlling disease outbreaks
4. Better understanding of blood vessel constrictor needed to harness its power for patients
5. Pictures of hot fudge sundaes arouse: Understanding emotions improves our food choices
6. Gaining a better understanding of kidney diseases
7. Do 68 molecules hold the key to understanding disease?
8. Trichoplax genome sequenced -- rosetta stone for understanding evolution
9. Characterization of grapevine transposons furthers understanding of in vino variety
10. Genome of saltwater creature could aid understanding of gene grouping
11. Holistic understanding: Ag chemicals in the environment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Understanding how oxidative stress impairs endothelial progenitor cell function
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... ... 6” modular downlights designed to stay tightly sealed and perform efficiently for years. ... and wet location listings just aren't enough, such as: hospitals; behavioral health facilities; ...
(Date:8/14/2017)... (PRWEB) , ... August 14, 2017 , ... ... characterized and performing antibodies. Key researchers in the antibody community have recently come ... and consistency for antibodies in the laboratory. , The team at ...
(Date:8/11/2017)... San Antonio, Texas (PRWEB) , ... August 11, 2017 , ... ... launching a rebranding campaign this month that will incorporate important key elements including a ... to thank the community that has supported them, Bill Miller has partnered with the ...
(Date:8/10/2017)... , ... August 09, 2017 , ... ... classroom next week-- as students. From August 14th through the 16th, the University ... which debuted in the summer of 2016, provides Philadelphia-based middle school educators an ...
Breaking Biology Technology: