Navigation Links
Understanding how bacteria come back from the dead
Date:2/2/2012

Salmonella remains a serious cause of food poisoning in the UK and throughout the EU, in part due to its ability to thrive and quickly adapt to the different environments in which it can grow. New research involving a team of IFR scientists, funded by BBSRC, has taken the first detailed look at what Salmonella does when it enters a new environment, which could provide clues to finding new ways of reducing transmission through the food chain and preventing human illness.

Bacteria can multiply rapidly, potentially doubling every 20 minutes in ideal conditions. However, this exponential growth phase is preceded by a period known as lag phase, where no increase in cell number is seen. Lag phase was first described in the 19th Century, and was assumed to be needed by bacteria to prepare to exploit new environmental conditions. Beyond this, surprisingly little was known about lag phase, other than bacteria are metabolically active in this period. But exactly what are bacteria doing physiologically during this period?

To fill in this knowledge gap researchers at IFR, along with colleagues at Campden BRI, a membership-based organisation carrying out research and development for the food and drinks industry, have developed a simple and robust system for studying the biology of Salmonella during lag phase. In this system, lag phase lasts about two hours, but the cells sense their new environment remarkably quickly, and within four minutes switch on a specific set of genes, including some that control the uptake of specific nutrients.

For example, one nutrient accumulated is phosphate which is needed for many cellular processes, and a gene encoding a phosphate transporter was the most upregulated gene during the first four minutes of lag phase. The cellular uptake mechanisms for iron were also activated during lag phase, and are needed for key aspects of bacterial metabolism. This increase in iron leads to a short term sensitivity to oxidative damage. Manganese and calcium are also accumulated in lag phase, but are lost from the cell during exponential growth.

This new understanding of Salmonella metabolism during lag phase show how rapidly Salmonella senses favourable conditions and builds up the materials needed for growth. This study was carried out by two BBSRC-CASE studentships, which were partially funded by Campden BRI.

Future research to work out the regulatory mechanisms behind these processes and the switch from lag phase to exponential growth will tell us more about how Salmonella can flourish in different environments, and could point to new ways of controlling its transmission in the food chain.


'/>"/>
Contact: Andrew Chapple
andrew.chapple@ifr.ac.uk
01-603-251-490
Norwich BioScience Institutes
Source:Eurekalert

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Proteins in sperm unlock understanding of male infertility says new study
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Understanding how oxidative stress impairs endothelial progenitor cell function
5. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
6. New technique is quantum leap forward in understanding proteins
7. Understanding extinct microbes may influence the state of modern human health
8. Understanding phosphorus in soils is vital to proper management
9. Biologist receives the 2008 AAAS Public Understanding of Science and Technology Award
10. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
11. Understanding natural crop defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use ... Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington ... Delta,s biometric boarding pass experience that ... integrated into the boarding process to allow eligible Delta SkyMiles Members who ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces the launch of the ... of steps needed to gain kinetic binding data for a wide range of ...
(Date:8/15/2017)... Kenosha, Wisconsin (PRWEB) , ... August 15, 2017 ... ... introduced a new family of 6” modular downlights designed to stay tightly sealed ... applications, including areas where damp and wet location listings just aren't enough, such ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... encrypted shopping cart. Now mobile responsive, the new website makes it easy to ... anywhere in between. Users can now find detailed product information, educational industry content ...
(Date:8/14/2017)... York, NY (PRWEB) , ... August 14, 2017 , ... ... in Clinical Trials event, which will take place on September 6, 2017 at ... Daniel Karlin, MD , Head of Experimental Medicine, Informatics, and Regulatory Strategy, Pfizer Innovative ...
Breaking Biology Technology: