Navigation Links
Understanding diabetes at the molecular level
Date:11/5/2010

United States and Japanese researchers have identified a key step in metabolic pathways linked to diabetes and cancer. The study on activation of the protein complex TORC 2 was published online in the journal Current Biology Oct. 28.

TORC 2 activates a protein called Akt, which plays a crucial role in how cells respond to insulin, said Kazuo Shiozaki, professor of microbiology in the College of Biological Sciences at UC Davis and senior author on the paper.

Normally, insulin triggers fat and muscle cells to take up sugar from the blood. Patients with type II diabetes make plenty of insulin, but their cells do not respond to it properly. Akt plays a role in the series of steps between insulin exposure and sugar uptake; specifically, it causes proteins that take sugar from the blood to move to the cell surface. Mice that lack the gene for Akt develop diabetes-like symptoms.

"We know that Akt is a key player in diabetes, so we are trying to work upstream from there," Shiozaki said.

Akt also controls cell growth in early embryos and can promote the growth of cancer cells, he added.

Since TORC 2 was first identified in 2005 as a regulator of Akt, researchers have been trying to identify how it is activated, Shiozaki said. The complex appears to be very similar across organisms ranging from humans to yeast.

Shiozaki and colleagues Hisashi Tatebe, Susumu Morigasaki, Shinichi Murayama and Cui Tracy Zeng studied TORC 2 in a yeast. They found that a protein called Ryh1, when bound to another molecule called guanosine triphosphate, is needed to activate TORC 2.

Yeast strains that had a defective form of Ryh1 were more sensitive to temperature or other stressful conditions.

Ryh1 is very similar to a human protein, Rab6. The researchers found that human Rab6 could to some extent replace yeast Ryh1 as an activator of TORC 2 in defective yeast strains.

Rab6 belongs to a class of proteins better known for moving other proteins around within cells. This suggests that Rab6 might play a dual role in insulin signaling, Shiozaki said.

"Our discovery suggests that the early and late steps in insulin response are closely linked to each other," Shiozaki said.


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Proteins in sperm unlock understanding of male infertility says new study
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Understanding how oxidative stress impairs endothelial progenitor cell function
5. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
6. New technique is quantum leap forward in understanding proteins
7. Understanding extinct microbes may influence the state of modern human health
8. Understanding phosphorus in soils is vital to proper management
9. Biologist receives the 2008 AAAS Public Understanding of Science and Technology Award
10. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
11. Understanding natural crop defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Any expert in stem cell research or ... for more than half a century. Despite their essential roles in human health ... known that molecular tags developed for this purpose also tag other, more abundant, non-stem ...
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA ... responsive, the new website makes it easy to navigate through the site whether ... now find detailed product information, educational industry content and visit the company’s social ...
(Date:8/11/2017)... 11, 2017  Market researcher Kalorama Information ... article regarding the telemedicine market.  The telemedicine ... Information.  The article, "Heart and Asthma ...  used information from Kalorama Information,s Remote Patient ... Market  (Sleep, Diabetes, Vital Signs /EKG ...
(Date:8/10/2017)... ... August 09, 2017 , ... As a full-service ... its ideal customers with the right message. Their effective, cutting-edge inbound marketing strategies ... we realize how crucial the agriculture industry is,” said David Phelps, chief marketing ...
Breaking Biology Technology: