Navigation Links
Understanding cancer using the fruit fly
Date:8/23/2010

Changes to proteins in a cell underlay many cancers. Rui Martinho at the Instituto Gulbenkian de Cincia (IGC), in Portugal, in collaboration with researchers in Ghent (Belgium) and Bergen (Norway) will use the fruit fly to understand exactly how changes to proteins, identified in the test-tube, impact on the way cells divide in a living organism. This study, funded by the Association for International Cancer Research (AICR), will provide inroads into understanding the development of cancer.

Many proteins are modified as they are produced in the cell. Certain molecular groups, such as the acetyl group, can be added to the end of a nascent protein, in a process called N-terminal acetylation. Specific enzymes mediate these modifications which in fact very common (80-90% of human proteins are modified in this manner). These changes affect a wide range of cellular functions during cell division and apoptosis (programmed cell death), essential for the balance of the organism, but they may also be involved in the development of cancer.

It is known that the enzymes responsible for these modifications are over-expressed in certain aggressive cancers, although the biological importance and consequences of their activity is not well understood. Rui Martinho and his collaborators propose to unravel the mode of action of one of these enzymes, in the fruit fly (Drosophila melanogaster).

Says Rui Martinho, 'We will focus on the enzyme San, to try to identify its targets, regulation and the consequences of its actions and, ultimately, its impact on how cells divide. This approach will allow a better understanding of the role of these modifications in tissue proliferation and cancer development in a context closer to our own, rather than in cell cultures and unicellular organisms, as previous studies have done.

AICR is he leading charity funding cancer research around the world whose aims are to save lives by investing in vital research to improve the prevention, diagnosis and treatment cancer.

Dr Mark Matfield of AICR says "Rui Martinho fought off stiff competition from around the world in order to get this funding and we are looking forward to seeing what light his research will shed on the cancer research field'.


'/>"/>

Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Source:Eurekalert

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Proteins in sperm unlock understanding of male infertility says new study
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Understanding how oxidative stress impairs endothelial progenitor cell function
5. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
6. New technique is quantum leap forward in understanding proteins
7. Understanding extinct microbes may influence the state of modern human health
8. Understanding phosphorus in soils is vital to proper management
9. Biologist receives the 2008 AAAS Public Understanding of Science and Technology Award
10. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
11. Understanding natural crop defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
(Date:1/22/2016)... , Jan. 22, 2016 ... addition of the "Global Biometrics Market ... their offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> Research and Markets ( ...
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016  Dovetail Genomics™ LLC today announced that ... for a planned metagenomic genome assembly service. Richard ... genome assembly method in a talk on Friday, February ... Technology conference in Orlando, Fla. ... datasets is difficult. Using its proprietary Chicago ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... cell treatment clinic in Quito, Ecuador. The new facility will provide advanced protocols ... patients from around the world. , The new GSCG clinic is headed ...
(Date:2/10/2016)... ASAE is introducing a hybrid membership model which will ... of joining or renewing through an organizational purchasing model. ... every employee in any size association or AMC office ... member benefits.   John H. Graham, IV ... allow organizations of any size and their employees to ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... three states, announced today the promotion of two long-standing principal investigators (PI) to ... Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, a Benchmark Research ...
Breaking Biology Technology: