Navigation Links
Understanding cancer using the fruit fly
Date:8/23/2010

Changes to proteins in a cell underlay many cancers. Rui Martinho at the Instituto Gulbenkian de Cincia (IGC), in Portugal, in collaboration with researchers in Ghent (Belgium) and Bergen (Norway) will use the fruit fly to understand exactly how changes to proteins, identified in the test-tube, impact on the way cells divide in a living organism. This study, funded by the Association for International Cancer Research (AICR), will provide inroads into understanding the development of cancer.

Many proteins are modified as they are produced in the cell. Certain molecular groups, such as the acetyl group, can be added to the end of a nascent protein, in a process called N-terminal acetylation. Specific enzymes mediate these modifications which in fact very common (80-90% of human proteins are modified in this manner). These changes affect a wide range of cellular functions during cell division and apoptosis (programmed cell death), essential for the balance of the organism, but they may also be involved in the development of cancer.

It is known that the enzymes responsible for these modifications are over-expressed in certain aggressive cancers, although the biological importance and consequences of their activity is not well understood. Rui Martinho and his collaborators propose to unravel the mode of action of one of these enzymes, in the fruit fly (Drosophila melanogaster).

Says Rui Martinho, 'We will focus on the enzyme San, to try to identify its targets, regulation and the consequences of its actions and, ultimately, its impact on how cells divide. This approach will allow a better understanding of the role of these modifications in tissue proliferation and cancer development in a context closer to our own, rather than in cell cultures and unicellular organisms, as previous studies have done.

AICR is he leading charity funding cancer research around the world whose aims are to save lives by investing in vital research to improve the prevention, diagnosis and treatment cancer.

Dr Mark Matfield of AICR says "Rui Martinho fought off stiff competition from around the world in order to get this funding and we are looking forward to seeing what light his research will shed on the cancer research field'.


'/>"/>

Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Source:Eurekalert

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Proteins in sperm unlock understanding of male infertility says new study
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Understanding how oxidative stress impairs endothelial progenitor cell function
5. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
6. New technique is quantum leap forward in understanding proteins
7. Understanding extinct microbes may influence the state of modern human health
8. Understanding phosphorus in soils is vital to proper management
9. Biologist receives the 2008 AAAS Public Understanding of Science and Technology Award
10. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
11. Understanding natural crop defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building ... corporate rebranding initiative announced today. The bold new look is part of a ... company moves into a significant growth period. , It will also expand its service ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which ... video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). ...
Breaking Biology Technology: