Navigation Links
Understanding cancer using the fruit fly
Date:8/23/2010

Changes to proteins in a cell underlay many cancers. Rui Martinho at the Instituto Gulbenkian de Cincia (IGC), in Portugal, in collaboration with researchers in Ghent (Belgium) and Bergen (Norway) will use the fruit fly to understand exactly how changes to proteins, identified in the test-tube, impact on the way cells divide in a living organism. This study, funded by the Association for International Cancer Research (AICR), will provide inroads into understanding the development of cancer.

Many proteins are modified as they are produced in the cell. Certain molecular groups, such as the acetyl group, can be added to the end of a nascent protein, in a process called N-terminal acetylation. Specific enzymes mediate these modifications which in fact very common (80-90% of human proteins are modified in this manner). These changes affect a wide range of cellular functions during cell division and apoptosis (programmed cell death), essential for the balance of the organism, but they may also be involved in the development of cancer.

It is known that the enzymes responsible for these modifications are over-expressed in certain aggressive cancers, although the biological importance and consequences of their activity is not well understood. Rui Martinho and his collaborators propose to unravel the mode of action of one of these enzymes, in the fruit fly (Drosophila melanogaster).

Says Rui Martinho, 'We will focus on the enzyme San, to try to identify its targets, regulation and the consequences of its actions and, ultimately, its impact on how cells divide. This approach will allow a better understanding of the role of these modifications in tissue proliferation and cancer development in a context closer to our own, rather than in cell cultures and unicellular organisms, as previous studies have done.

AICR is he leading charity funding cancer research around the world whose aims are to save lives by investing in vital research to improve the prevention, diagnosis and treatment cancer.

Dr Mark Matfield of AICR says "Rui Martinho fought off stiff competition from around the world in order to get this funding and we are looking forward to seeing what light his research will shed on the cancer research field'.


'/>"/>

Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Source:Eurekalert

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Proteins in sperm unlock understanding of male infertility says new study
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Understanding how oxidative stress impairs endothelial progenitor cell function
5. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
6. New technique is quantum leap forward in understanding proteins
7. Understanding extinct microbes may influence the state of modern human health
8. Understanding phosphorus in soils is vital to proper management
9. Biologist receives the 2008 AAAS Public Understanding of Science and Technology Award
10. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
11. Understanding natural crop defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2016)... MINNETONKA, Minn. , Nov. 22, 2016   ... that supports the entire spectrum of clinical research, is ... by Medical LiveWire Healthcare and Life Sciences Awards ... This award caps off an unprecedented year of recognition ... clinical trials for over 15 years. iMedNet ...
(Date:11/16/2016)... , Nov. 16, 2016 Sensory Inc ... and security for consumer electronics, and VeriTran ... and retail industry, today announced a global partnership ... way to authenticate users of mobile banking and ... TrulySecure™ software which requires no specialized biometric ...
(Date:6/27/2016)... 27, 2016 Research and Markets has announced ... report to their offering. ... to grow at a CAGR of 12.28% during the ... on an in-depth market analysis with inputs from industry experts. The ... coming years. The report also includes a discussion of the key ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... Nov. 30, 2016  The Allen Institute for ... the first publicly available collection of gene edited, ... target key cellular structures with unprecedented clarity. Distributed ... powerful tools are a crucial first step toward ... understand what makes human cells healthy and what ...
(Date:11/30/2016)... , Nov. 30, 2016  Tempus, a ... cancer care, and Penn,s Abramson Cancer Center have ... a positive response to immunotherapy treatment based on ... As part of a research collaboration, Tempus ... and melanoma cancer patient data to Penn. Utilizing ...
(Date:11/30/2016)... , 30. November 2016   Merck ... heute die Unterzeichnung einer Reihe von Vereinbarungen ... wird Evotec AG Screeningleistungen für Mercks Palette ... Der Zugriff auf diese Bibliotheken in Kombination ... einen schnelleren Weg zur Ermittlung und Erforschung ...
(Date:11/30/2016)... --  Merck , a leading science and technology company, ... of agreements with Evotec AG, whereby Evotec AG will ... such as CRISPR and shRNA libraries. Combining access to ... pathway to explore and identify new drug targets. ... targets, a process that can be time- and labor-intensive," ...
Breaking Biology Technology: