Navigation Links
Understanding and treating the cognitive dysfunction of Down syndrome and Alzheimer's disease
Date:3/1/2012

Philadelphia, PA, March 1, 2012 Down syndrome (DS) is the most common genetic disorder in live born children arising as a consequence of a chromosomal abnormality. It occurs as a result of having three copies of chromosome 21, instead of the usual two. It causes substantial physical and behavioral abnormalities, including life-long cognitive dysfunction that can range from mild to severe but which further deteriorates as individuals with DS age.

It is not currently possible to effectively treat the cognitive impairments associated with DS. However, these deficits are an increasing focus of research. In this issue of Biological Psychiatry, researchers at Stanford University, led by Dr. Ahmad Salehi, have published a review which highlights potential strategies for the treatment of these cognitive deficits.

The authors focus on insights emerging from animal models of Down syndrome and outline the structural abnormalities in the DS brain. They also discuss studies that have linked the overexpression of the amyloid precursor protein gene, called APP, to the degeneration of neurons in mice. These findings have led to the development of therapeutic treatments in mice, which now must be tested in humans.

"For more than a decade, we have been working on identifying a strategy to treat cognitive disabilities in our Down syndrome mouse models," said Dr. Salehi. "Considering the research and results with mouse models as an indication of success of a strategy in humans, we are ever closer to finding ways to at least partially restore cognitive function in children and adults with Down syndrome."

Interestingly, this research is also providing insights into Alzheimer's disease (AD), the archetypal disorder of late life. All adults with Down syndrome develop AD pathology by age 40, and there are some remarkable similarities in the brain degeneration and cognitive dysfunction of individuals with DS and those with AD.

The lea
'/>"/>

Contact: Rhiannon Bugno
biol.psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. A breakthrough in understanding the biology and treatment of ovarian cancer
2. Understanding how bacteria come back from the dead
3. Shane Ross garners CAREER Award to advance understanding of fluid flows from blood inside the body to oil spills in bodies of water
4. Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
5. Understanding causes of obesity in Aboriginal children
6. Scripps Research scientists provide new understanding of chronic pain
7. A firmer understanding of muscle fibrosis
8. Step forward in foot-and-mouth disease understanding
9. Lighting the way to understanding the brain
10. A new model for understanding biodiversity
11. Introducing L-PEACH: Tool for understanding peach tree development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program has ... of Human Genetics from October 18 22, 2014 ... to promote the entry of students, post doctorates and ... basic science community and to encourage the participation of ... This year MARC conferred 16 awards totaling $29,600., ...
(Date:8/28/2014)... Athens, Ga. The support of peer groups ... effective breastfeeding programs, according to recent University of ... mothers in the Athens-Clarke County area determined that ... the outcomes of mothers of infants. , "Mothers ... be successful at breastfeeding," said study co-author Alex ...
(Date:8/28/2014)... MD FASEB MARC (Maximizing Access to Research ... for the American College of Sports Medicine,s Conference ... 2014 in Miami, Florida. These awards are ... doctorates and scientists from underrepresented groups into the ... encourage the participation of young scientists at the ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
... granted a University of Texas at Dallas researcher and ... nerve stimulation offers a long-term cure for tinnitus. ... 20 percent to 40 percent of recently returned military ... 65 years old. The U.S. Veterans Administration spends about ...
... COLLEGE PARK, Md. - The University of Maryland, ... University of Maryland Baltimore County, has received a $7.9 ... Nuclear Magnetic Resonance (NMR) magnet that will help researchers ... to treat cancer, AIDS and other diseases. The ...
... Binh An Diep, Ph.D., Assistant Adjunct Professor, Department ... chosen by the American Society for Microbiology (ASM) to ... Merck, U.S. Human Health Division, this award recognizes an ... infectious diseases. Dr. Diep earned his B.A. in ...
Cached Biology News:Tinnitus study looks for cure to 'ringing in the ears' 2Tinnitus study looks for cure to 'ringing in the ears' 3University of Maryland partnership receives $7.9M from NIH for superconducting research magnet 2University of Maryland partnership receives $7.9M from NIH for superconducting research magnet 3
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... 29, 2014 A major challenge before ... start-up dense realm of Boston-Cambridge, is gaining visibility that ... James Sherley, the Director of Boston’s Adult Stem Cell ... and national visibility of his company an important priority ... In addition to a social media marketing campaign ...
(Date:8/28/2014)... DIEGO, California, USA (PRWEB) August 28, 2014 ... the Department of Physics and Optical Science and Director ... the University of North Carolina at Charlotte, and co-founder ... been elected to serve as the 2015 Vice President ... , SPIE 2014 President Philip Stahl announced recent election ...
(Date:8/28/2014)... Nevada City, Ca. (PRWEB) August 28, 2014 ... an E3 rating for an alcohol-based hand sanitizer, asks ... fall harvest by comparing the hand sanitizer they’re currently ... Sanitizer Spray . Hand hygiene is critical to fighting ... processing environment. Best Sanitizers believes there are key ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... need medications, there is often concern about possible effects ... to cause birth defects (thalidomide being a notorious example), ... is known about most drugs, level of risk. Researchers ... created a preclinical model for predicting a drug,s teratogenicity ...
... Advanced Life Sciences Holdings, Inc. (OTC ... engaged in the discovery, development and commercialization of novel ... respiratory diseases, today announced that it will present at ... 10-12th in San Francisco. (Logo: ...
... NEOG ) announced today that its net income ... 30, increased 33% from the previous year,s second quarter. Net ... share, compared to the prior year,s $0.20. Second ... year,s $35,251,000. Year-to-date revenues for the first six months of ...
Cached Biology Technology:Model Predicts a Drug's Likelihood of Causing Birth Defects 2Model Predicts a Drug's Likelihood of Causing Birth Defects 3Advanced Life Sciences to Present at the Biotech Showcase™ 2011 Conference 2Neogen Reports 33% Increase in Net Income 2Neogen Reports 33% Increase in Net Income 3Neogen Reports 33% Increase in Net Income 4Neogen Reports 33% Increase in Net Income 5
... Radiochemical Purity is >95%NEN Radiolabeled Ligands\n\nReceptor-related research ... availability of new radiolabeled ligands selected to ... a wide range of products and services ... over 400 state-of-the-art radioligands. If you do ...
... Advion's NanoMate 100 robotic system and ... full advantage of the capabilities of electrospray ... the NanoMate with MS allows users to ... small molecule and peptide mapping applications, or ...
... Dynamic Focusing MALDI (PDF-MALDI) source provides fast, ... do not need online separation. Paired with ... and Agilents powerful Spectrum Mill software, the ... of 2D gel-spot digests. It provides clean, ...
... Vibratome Roto-Shake Genie is an all-in-one ... It performs five different mixing motions: ... rotating/rolling, as well as a combination ... precision-engineered moving portion of the Vibraotme ...
Biology Products: