Navigation Links
Understanding and treating the cognitive dysfunction of Down syndrome and Alzheimer's disease
Date:3/1/2012

Philadelphia, PA, March 1, 2012 Down syndrome (DS) is the most common genetic disorder in live born children arising as a consequence of a chromosomal abnormality. It occurs as a result of having three copies of chromosome 21, instead of the usual two. It causes substantial physical and behavioral abnormalities, including life-long cognitive dysfunction that can range from mild to severe but which further deteriorates as individuals with DS age.

It is not currently possible to effectively treat the cognitive impairments associated with DS. However, these deficits are an increasing focus of research. In this issue of Biological Psychiatry, researchers at Stanford University, led by Dr. Ahmad Salehi, have published a review which highlights potential strategies for the treatment of these cognitive deficits.

The authors focus on insights emerging from animal models of Down syndrome and outline the structural abnormalities in the DS brain. They also discuss studies that have linked the overexpression of the amyloid precursor protein gene, called APP, to the degeneration of neurons in mice. These findings have led to the development of therapeutic treatments in mice, which now must be tested in humans.

"For more than a decade, we have been working on identifying a strategy to treat cognitive disabilities in our Down syndrome mouse models," said Dr. Salehi. "Considering the research and results with mouse models as an indication of success of a strategy in humans, we are ever closer to finding ways to at least partially restore cognitive function in children and adults with Down syndrome."

Interestingly, this research is also providing insights into Alzheimer's disease (AD), the archetypal disorder of late life. All adults with Down syndrome develop AD pathology by age 40, and there are some remarkable similarities in the brain degeneration and cognitive dysfunction of individuals with DS and those with AD.

The lea
'/>"/>

Contact: Rhiannon Bugno
biol.psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. A breakthrough in understanding the biology and treatment of ovarian cancer
2. Understanding how bacteria come back from the dead
3. Shane Ross garners CAREER Award to advance understanding of fluid flows from blood inside the body to oil spills in bodies of water
4. Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
5. Understanding causes of obesity in Aboriginal children
6. Scripps Research scientists provide new understanding of chronic pain
7. A firmer understanding of muscle fibrosis
8. Step forward in foot-and-mouth disease understanding
9. Lighting the way to understanding the brain
10. A new model for understanding biodiversity
11. Introducing L-PEACH: Tool for understanding peach tree development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... 17, 2013) Illustrating a commitment to the ... Gastroenterological Association (AGA) Research Foundation has announced the ... Fellowship Award recipients. Supported by the National Institute ... this new award helps underrepresented minority students to ... nutrition research. , "By establishing this new award, ...
(Date:5/16/2013)... closer to a fast food restaurant had a higher ... away from fast food, according to researchers at The ... association was particularly strong among those with a lower ... the American Journal of Public Health indicates ... food restaurant, and among lower-income African-Americans, the density, or ...
(Date:5/16/2013)... nanoparticles developed at MIT may someday eliminate the ... constantly monitor their blood-sugar levels and inject themselves ... sense glucose levels in the body and respond ... replacing the function of pancreatic islet cells, which ... Ultimately, this type of system could ensure that ...
Breaking Biology News(10 mins):Underrepresented minority students receive fellowships in digestive disease and nutrition research 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 3Nanotechnology could help fight diabetes 2Nanotechnology could help fight diabetes 3
... Zurich, Switzerland, August 18, 2009 / b3c newswire ... that, following the successful completion of key research ... disease has advanced into preclinical development, triggering milestone ... (NASDAQ: BIIB). Neurimmune partnered with Biogen Idec for ...
... Why is it that you can instantly recall your own phone ... a new number you heard a few moments ago? The two ... long-term and short-term, respectively that are stored very differently ... the animal kingdom, even in insects such as the fruit fly. ...
... by lightning strikes, Victor Ugaz, associate professor in the ... University, has created a network of microchannels that could ... a three-dimensional vasculature for the support of larger tissue ... undertaken with colleague Arul Jayaraman and appears in the ...
Cached Biology News:Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development 2Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development 3CSHL study finds short- and long-term memories require same gene but in different circuits 2CSHL study finds short- and long-term memories require same gene but in different circuits 3Researcher says microchannels could advance tissue engineering methods 2Researcher says microchannels could advance tissue engineering methods 3Researcher says microchannels could advance tissue engineering methods 4
(Date:5/20/2013)... May 20, 2013 Recognizing exciting ... faculty members to its 2013 Class of Young ... company will provide this outstanding international group with ... advancing basic science to meet global challenges.     , ... help promising young and untenured research faculty working ...
(Date:5/19/2013)... Switzerland’s MS Tûranor PlanetSolar , ... speed record for a transatlantic crossing by a solar ... April 25, 2013, the solar powered boat sailed 2,867miles ... speed of 5.3 knots before reaching Marigot, St. Martin, ... The first-of-its-kind catamaran completed this year’s passage across the ...
(Date:5/17/2013)... when the transplant recipient,s immune system identifies the transplanted ... previously thought that T cells, the immune cells that ... as chemokines in order to migrate to the transplanted ... Clinical Investigation , Fadi Lakkis and colleagues at the ... stimulation of T cells is not required for migration. ...
(Date:5/17/2013)... PHILADELPHIA , May 17, 2013 ... held by the most innovative thought leaders of ... Device & Manufacturing East conference and expo, from ...      (Photo: http://photos.prnewswire.com/prnh/20130517/613829 ) ... were designed to deliver industry professionals practical presentations ...
Breaking Biology Technology:DuPont Celebrates Scientific Innovation by Recognizing Young Professors 2DuPont Celebrates Scientific Innovation by Recognizing Young Professors 3MS Tûranor PlanetSolar Sets World Speed Record for Transatlantic Crossing by Solar Electric Vessel 2MS Tûranor PlanetSolar Sets World Speed Record for Transatlantic Crossing by Solar Electric Vessel 3MS Tûranor PlanetSolar Sets World Speed Record for Transatlantic Crossing by Solar Electric Vessel 4MS Tûranor PlanetSolar Sets World Speed Record for Transatlantic Crossing by Solar Electric Vessel 5MS Tûranor PlanetSolar Sets World Speed Record for Transatlantic Crossing by Solar Electric Vessel 6MedTech Innovate Seminars: New Interactive Learning Forums at 2013 MD&M East 2
... JERUSALEM , May 18, 2010 ... MD, joins Oramed,Pharmaceuticals, Board of Directors. Dr. Berelowitz is currently Senior Vice,President ... Unit at Pfizer, Inc., the world,s largest,research-based pharmaceutical company. , ... Dr. Berelowitz joined ...
... Pfizer Global Manufacturing announced today plans to reconfigure its ... supply organization from the combined networks of Pfizer (NYSE: ... phase of Pfizer,s previously announced Plant Network Strategy includes recommendations ... , Puerto Rico , and the United States ...
... 2010 , , , ... , , , ... cleared by FDA for Home/Self use and is,consequently available to all patients with home hemodialysis ... use has already improved in-clinic patient,safety. Optimizing safety conditions for home hemodialysis users is a ...
Cached Biology Technology:Oramed Pharmaceuticals Announces That Dr. Michael Berelowitz, Senior Vice President at Pfizer, Joins its Board of Directors 2Oramed Pharmaceuticals Announces That Dr. Michael Berelowitz, Senior Vice President at Pfizer, Joins its Board of Directors 3Pfizer Global Manufacturing Announces Plans to Reconfigure Its Global Plant Network 2Pfizer Global Manufacturing Announces Plans to Reconfigure Its Global Plant Network 3Pfizer Global Manufacturing Announces Plans to Reconfigure Its Global Plant Network 4Pfizer Global Manufacturing Announces Plans to Reconfigure Its Global Plant Network 5Pfizer Global Manufacturing Announces Plans to Reconfigure Its Global Plant Network 6Pfizer Global Manufacturing Announces Plans to Reconfigure Its Global Plant Network 7Redsense Medical Receives FDA Clearance for the Redsense Safety Device for Home/Self use During Home Hemodialysis 2
Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to KLH...
Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2). [Source:Uniprot/SWISSPROT;Acc:P19878] Antigen: Recombinant Protein E...
Rabbit polyclonal to MA2 ( Abpromise for all tested applications). entrezGeneID: 10687 SwissProtID: Q9UL42...
... Rabbit polyclonal to FANCM ( Abpromise ... Antigen: Synthetic peptide derived from ... Human FANCM. (Note: the amino acid ... available as ab27787 .) ...
Biology Products: