Navigation Links
Understanding a bacterial immune system 1 step at a time
Date:5/17/2011

Researchers at the University of Alberta have taken an important step in understanding an immune system of bacteria, a finding that could have implications for medical care and both the pharmaceutical and dairy industries.

In research published in the high impact journal Nature Structural & Molecular Biology, Andrew MacMillan and co-workers in his lab have described the first step of the immune response of bacterial cells. Scientists had previously found that a bacterial virus, called a bacteriophage, attacks a bacterial cell by injecting its DNA in to the cell. MacMillan's lab discovered the mechanism by which bacterial RNA is cut into pieces by a specific protein; these pieces then target the invading virus' DNA.

"We are starting at the beginning because we want to understand how this works and how we can use this to basically control bacterial growth," said Matt Schellenberg, a post-doctoral fellow in the MacMillan lab in the department of biochemistry in the Faculty of Medicine & Dentistry. This system could be beneficial for bacteria to fight off invasion of viruses. Alternatively, medical professionals could use knowledge of this system to help fight a human bacterial infection.

According to MacMillan they used a technique called X-ray crystallography to produce high-resolution pictures of a key step in the bacteria's immune response the production of the targeting RNAs.

"Bacteria have evolved this system to protect themselves against infection," said MacMillan.

As they unfold the mystery of the bacteria cells immune system, which is named the CRISPR system, there are implications for a variety of industrial practices involving fermentation. Everything from cheese and yogurt production to the synthesis of complex pharmaceuticals relies on large scale bacterial fermentation which is at risk of bacteriophage infection with expensive consequences losing the batch. The labs ongoing work could help these industries boost the immune systems of the "good" bacteria.

The next step for the lab is to uncover the mechanism by which virus' DNA is destroyed.

"We want to use what we've learned so far to examine the actual targeting mechanism," says Macmillan. "This is a complex pathway and there's a lot of exciting biology to still uncover."


'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Proteins in sperm unlock understanding of male infertility says new study
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Understanding how oxidative stress impairs endothelial progenitor cell function
5. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
6. New technique is quantum leap forward in understanding proteins
7. Understanding extinct microbes may influence the state of modern human health
8. Understanding phosphorus in soils is vital to proper management
9. Biologist receives the 2008 AAAS Public Understanding of Science and Technology Award
10. Diminuendo -- New mouse model for understanding cause of progressive hearing loss
11. Understanding natural crop defenses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
(Date:5/9/2016)... Elevay is currently known as ... for high net worth professionals seeking travel for work ... world, there is still no substitute for a face-to-face ... your deal with a firm handshake. This is why ... of citizenship via investment programs like those offered by ...
(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... services, but it also plays a fundamental part in enabling ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the Pennsylvania Convention Center and will showcase its product’s latest features from June ... be presenting a scientific poster on Disrupting Clinical Trials in The Cloud during ...
Breaking Biology Technology: