Navigation Links
Undergrad has sweet success with invention of artificial Golgi
Date:5/7/2008

e they are exposed to a variety of enzymes found in the natural Golgi. The resulting sugars can then be tested on living cells either on the chip or in the lab to determine their effects. With the chips ability to process many combinations of sugars and enzymes, it could help researchers quickly uncover new sugar-based drugs, according to Martin.

Scientists have known for years that certain sugars can serve as extremely beneficial therapeutics for humans. One well-known example is heparin, which is among the most widely used drugs in the world. Heparin is formed naturally in the Golgi organelle in cells of the human body as well as in other animals like pigs. Heparin acts as an anticoagulant preventing blood clots, which makes it a good therapeutic for heart, stroke, and dialysis patients.

The main source of heparin is currently the intestines of foreign livestock and, as recent news reports highlight, the risk of contamination from such sources is high. So researchers are working around the clock to develop a safer, man-made alternative to the drug that will prevent outside contamination. A synthetic alternative would build the sugar from scratch, helping eliminate the possibility of contamination he explained.

I am very grateful to have the privilege of working with Dr. Linhardt who has discovered the recipe to make fully synthetic heparin, Martin said. Because we know the recipe, I am going to use it as a model to test the device. If our artificial Golgi can build fully functional heparin, we can then use the artificial organelle to produce many different sugar variants by altering the combination of enzymes used to synthesize them. Another great thing about these devices is that they are of microscale size, so that if needed we could fill an entire room with them to increase throughput for drug discovery.

There are millions of possible sugar combinations that can be formed and scientists currently only know the function of v
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. ASPB announces Summer Undergraduate Research Fellowship 2007 recipients
2. Woods Hole Research Center to lead undergraduate initiative in the Siberian Arctic
3. BGSU undergraduates to pilot groundbreaking genome project
4. Computational mathematical sciences receives NSF grant for undergraduate research
5. Katherine Freed wins first place at the International ISPE Undergraduate Poster Contest
6. Undergraduate bioscience research reaches new horizons
7. Outstanding undergraduates recognized in agronomy, crop, soil, and environmental sciences
8. To maximize biofuel potential, researchers look for sorghums sweet spot
9. Sweet smell
10. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
11. How sweet is it?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - ... partnership centralized around the incorporation of handyem,s HPC-150 ... diagnostic laboratory, the Mo-POD™. This unprecedented model of ... International Conference at the Pennsylvania ... from June 15 th to 18 th ...
(Date:6/15/2015)... A new report [ 1 ... of US consumers using mobile banking applications want their mobile ... and voiceprint, instead of having to prove who they are ... Mobile Identity   -   The Fusion of Financial Services, ... the primary channel used by Gen X and Gen Y ...
(Date:6/9/2015)... , June 9, 2015   MedNet Solutions , ... entire spectrum of clinical research, will be providing demonstrations ... platform at the 2015 Drug Information Association (DIA) Annual ... June 15-17.  These presentations will include previews of many ... in the upcoming iMedNet 2015 Feature 1 ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 3
... Inc. (OTC Markets: MDBX) ( www.medboxinc.com ), announced that their ... Colorado marijuana task force,s recommendations regarding "pot ... be made available to tourists over the age of 21, ... residents. Representative Dan Pabon (D), who ...
... origins of different isotope ratios among the elements that make ... ice and dust, Mark Thiemens and his colleagues hope to ... Division of Physical Sciences at the University of California, San ... In recent years his team has found the ...
... the 21st century, with all its technological marvels, but 6 ... have access to flush toilets or other adequate sanitation that ... effects, a new study has found. The research, published in ... number of people without access to improved sanitation is almost ...
Cached Biology News:Colorado Marijuana Task Force Gives Green Light To "Pot Tourism" 2Searching for the solar system's chemical recipe 2Searching for the solar system's chemical recipe 3Searching for the solar system's chemical recipe 4Searching for the solar system's chemical recipe 5
(Date:7/1/2015)... NEW YORK , July 1, 2015 /PRNewswire/ ... G ), a global leader in designing, ... the Aecus Innovation Award in recognition of their ... operational efficiencies in UCB,s global business services (GBS) ... acknowledge service providers and clients that work together ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... take part in the first half of “Integrative Biotechnology,” an applied biotechnology course ... in summer 2014, this course combines students from both universities and is taught ...
(Date:6/30/2015)... ... June 30, 2015 , ... Park Systems ... advanced scientific research into new classes of Nanoscale Graphene-based materials poised to revolutionize ... 'the wonder material of the 21st Century' by the researchers who were awarded ...
(Date:6/30/2015)... -- Juniper Pharmaceuticals, Inc. (Nasdaq: JNP ), a specialty ... unmet medical needs in women,s health, today announced ... at the Cantor Fitzgerald Inaugural Healthcare Conference as ... PM EDTLocation: , Le Parker Meridien Hotel, New ... under  ,Investor, or  click here The ...
Breaking Biology Technology:UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4Juniper Pharmaceuticals to Present at Cantor Fitzgerald Inaugural Healthcare Conference on July 8, 2015 2
... Stem Cell Biology Enhances, MacroGenics, Oncology Capabilities and Complements ... ... ROCKVILLE, Md., July 17 MacroGenics, Inc., a privately,held biotechnology ... diseases, today announced the,acquisition of Raven Biotechnologies, Inc., a privately ...
... FAIRFIELD, N.J., July 17 Arno Therapeutics,Inc. (OTC ... ticker,symbol on the OTC Bulletin Board has changed ... About Arno Therapeutics, Arno Therapeutics, Inc. is ... products for the treatment of,cancer patients. Arno,s lead ...
... TOKYO, and NEW DELHI, India, July 17 ... media and the stock market, Daiichi Sankyo,Company, ... Laboratories,Limited (NSE/BSE: Ranbaxy/500359) ("Ranbaxy") reiterate that the ... family, the largest,controlling shareholders of Ranbaxy, is ...
Cached Biology Technology:MacroGenics Acquires Raven Biotechnologies 2MacroGenics Acquires Raven Biotechnologies 3Arno Therapeutics Announces New Ticker Symbol 2Daiichi Sankyo and Ranbaxy Confirm Deal Is Binding and Final, Allay Market Rumour and Speculation 2
Rabbit anti Mouse ZIC2 Preservative: NaN3...
pH-dependent fluorescence; Maximum intensity observed in basic solutions....
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Biology Products: