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Uncovering the secrets of ulcer-causing bacteria
Date:8/12/2009

oft gel like mucus."

To answer the question Bansil, Shyam Erramilli and Jonathan Celli, also of Boston University, partnered with gastroenterologists Nezam Afdhal and Ciaran Kelly, and biochemists Sarah Keates, Bradley Turner and Ionita Ghiran at Harvard Medical School and mechanical and biomedical engineers Gareth McKinley, Peter So and Randy Ewoldt at MIT. The work began a few years ago as a feasibility study and was a part of Celli' Ph. D research.

Using video microscopes, the researchers found that when mucins extracted from mucus were in a liquid state, the bacteria could swim freely, but when mucins were in a gel state, the bacteria were stuck, even though their tails were rotating. More advanced imaging techniques revealed that pH changes directly correlated with the ability of the bacteria to move--the higher the pH, the greater the movement.

"This study indicates that the H. pylori, which is shaped very much like a screw, does not bore its way through the mucus gel like a screw through a cork as has previously been suggested," said Bansil. "Instead it achieves motility by using a clever biochemical strategy."

Researchers hope that the work will pave the way for future studies in native mucus and live animals to devise strategies for preventing H. pylori infection. Such studies could be important to the design of new therapeutic approaches that prevent the bacteria from colonizing in the first place, and also may be relevant to the broader question of bacterial infections in mucus linings in other organs.


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Contact: Bobbie Mixon
bmixon@nsf.gov
703-292-8485
National Science Foundation
Source:Eurekalert  

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