Navigation Links
Uncovering the genome's regulatory code
Date:9/10/2012

Since the sequencing of the human genome in 2001, all our genes around 20,000 in total have been identified. But much is still unknown for instance where and when each is active. Next to each gene sits a short DNA segment, and the activity of this regulatory segment determines whether the gene will be turned on, where and how strongly. These short regulatory segments are as if not more important than the genes, themselves. Indeed, 90% of the mutations that cause disease occur in these regulatory areas. They are responsible for the proper development of tissues and organs, determining, for instance, that eye cells and only eye cells contain light receptors, while only pancreatic cells function to produce insulin. Clearly, a deeper understanding of this regulatory system its mechanisms and possibilities for malfunction may lead to advances in biomedical research, especially in developing targeted therapies for individual patients.

In spite of their importance, the "regulatory code" is not well understood. To address this problem, a research team led by Dr. Ido Amit of the Weizmann Institute Immunology Department, together with scientists from the Broad Institute in Massachusetts, including Manuel Garber, Nir Yosef and Aviv Regev, and Nir Friedman of the Hebrew University of Jerusalem, developed an advanced, automated system for mapping these sites, and then used this system to uncover important principles how these regulatory elements function. Among other things, their study, which appeared in Molecular Cell, revealed a hierarchical structure for the regulatory code. By mapping a large number of regulatory factors, the team succeeded in revealing an overall plan for gene regulation as well as the intimate details of the mechanisms involved in the immune response.

"We are seeing a race to map the regulatory code and uncover its ties to disease and human variation that is reminiscent of the race to sequence the human genome," says Amit
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Thirty teams compete to interpret three families genomes
2. Differences in the genomes of related plant pathogens
3. Researchers announce GenomeSpace environment to connect genomic tools
4. Athletic frogs have faster-changing genomes
5. New research reveals challenges in genetically engineered crop regulatory process
6. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... Gino Pereira was interviewed on July 1 st ... Tampa Florida . Mr. Pereira discusses the company,s next ... and how the Wocket™ aims to replace a traditional ... Cedric Harris tells Gino he has never heard ...
(Date:7/10/2014)... July 7, 2014 According to ... "Electronic Access Control Systems Market Global Forecast, Market Share, ... global Electronic Access Control systems market was valued at ... grow at a CAGR of 12.6% from 2014 to ... million in 2019. Browse the full Electronic ...
(Date:7/10/2014)... to the large, mainly tropical flowering plant family Melastomataceae (Meadow ... family rely on bees for their pollination. Only about 100 ... The flowers of Axinaea appear in clusters of ... the different species are pink, yellow, orange or red. The ... colours of their bulbous appendages. The pollination mechanism of ...
Breaking Biology News(10 mins):Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5Novel type of bird pollination mechanism discovered in South America 2
... Men who develop breast cancer are often not treated ... treatment becomes difficult, new results show. Although most ... 1% of cases, Dr. Marina Garassino from the Orion ... organized by the European Society for Medical Oncology. ...
... beyond, humans have always wanted to fly. First ... unfailingly ended in disaster. No workable flying machines ... today there is little comparison between a top of ... similar flight patterns. In an era in which ...
... Diversity among the ancestors of such marine creatures as ... rise beginning 144 million years ago with no clear ... This contradicts previous work showing dramatic increases beginning 248 ... diversity. "Some of the time periods in the ...
Cached Biology News:Treatment delays result in poor outcomes for men with breast cancer 2Want to fly? Don't copy the birds and the bees 2Species have come and gone at different rates than previously believed 2Species have come and gone at different rates than previously believed 3
(Date:7/11/2014)... (PRWEB) July 11, 2014 Cayenne ... company specializing in the soft tissue reconstruction segment, ... Anchor System for surgeries involving the shoulder and ... through a novel, inserter-controlled deployment method. The unique ... partial deployment, anchor pull-out, or anchor displacement (also ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
(Date:7/10/2014)... 10, 2014 OMICS Group’s 5th International ... 18-20 August, 2014 at Double Tree by Hilton Beijing, ... developments in Analytical & Bioanalytical research methods only to ... on this occasion, Dr. Srinubabu Gedela, MD of OMICS ... is a remarkable one in bringing a unique and ...
(Date:7/10/2014)... ST. PETERSBURG, Russia , July 10, 2014 /PRNewswire/ ... the Russian Federation Dmitry Medvedev , presented ... a biopharmaceutical company BIOCAD . The Company is ... the scope of MabNext project BIOCAD develops a number ... of cancer and autoimmune diseases. The ceremony took place ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... as heat during the production of electricity could ... synthesized via a technique developed by researchers with ... National Laboratory (Berkeley Lab) and the University of ... of this technology include DOEs hydrogen fuel cell-powered ...
... HealthCare Technologies,Ltd., (the "Company") today announced that ... the Staff of the Listing Qualifications Department,(the "Staff ... indicated,that because the Staff believes that the Company,s ... on December 31, 2007, constituted a,reverse merger, the ...
... Seven Summits Research issues,PriceWatch Alerts for key stocks., ... http://www.iotogo.com/s/011008B (Note: You may have to ... key.), Today,s PriceWatch Alerts cover the following stocks: ... Co., Inc. (NYSE: MER ), DryShips, Inc. (Nasdaq:,DRYS), ...
Cached Biology Technology:Feeling the heat 2Feeling the heat 3Feeling the heat 4HealthCare Technologies Ltd. (NASDAQ: HCTL) Announces Receipt of NASDAQ Delisting Notice 2Seven Summits Research Releases Alerts on XOM, MER, DRYS, CSC, and PDLI 2Seven Summits Research Releases Alerts on XOM, MER, DRYS, CSC, and PDLI 3
... (patent pending) was developed using a protein engineering ... DNA binding pocket of wild-type DNase I. These ... for DNA. The result is a versatile enzyme ... and an ability to maintain at least 50% ...
Rabbit polyclonal to hnRNP-U...
... formation of a phosphodiester bonds between adjacent ... DNA molecules or between oligonucleotides which are ... 45 - 65?. Tfi DNA Ligase is ... than conventional DNA ligases, Thus, Tfi DNA ...
RABBIT ANTI RHEB (IN) Immunogen: A 15 amino acid peptide located in the central region of human Rheb....
Biology Products: