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Uncovering the genetics of prostate cancer
Date:1/20/2011

e genome of childhood brain tumors. Furthermore, scientists from DKFZ are partners in the German ICGC network for the analysis of malignant lymphomas.

Tasks distributed: Gathering, Sequencing, Analyzing

The various tasks of the ICGC project on early prostate cancer are headed by internationally acclaimed experts. The common goal is a comprehensive molecular analysis of prostate tumors. Using various methods, the researchers will capture the sequence of DNA building blocks in the cell nucleus. The sequence of DNA segments containing a blueprint for proteins will be analyzed separately. Another subproject will investigate DNA areas which are silenced by chemical labels known as epigenetic mutations. Yet another research group will study the small RNA molecules that regulate the activity of individual genes.

An extraordinary challenge is the analysis and storage of the unimaginable masses of data which are produced in the course of the International Cancer Genome Project. The genome of a cell is composed of about three billion building blocks, which are captured up to 30 times in various analyses in order to assure the quality of results. All data of the German ICGC projects will be joined together by Professor Roland Eils, who is head of the Theoretical Bioinformatics Division of DKFZ. To this end, Eils has built one of the world's largest data storage units for life sciences at the BioQuant Center of Heidelberg University. It will have a storage capacity of several petabytes - a petabyte is equal to one million gigabytes, or a one followed by 15 zeroes!

Subprojects and Project Heads

Patient selection, tissue preparation, histopathological and clinical classification of tumors, preparation of nucleic acids and clinical validation of genetic modifications: Guido Sauter (project co-coordinator), Institute of Pathology of the University Medical Center Hamburg- Eppendorf; Thorsten Schlomm, Hartwig Huland, Mar
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Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

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