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Uncovering the genetics of prostate cancer
Date:1/20/2011

hers aim to produce a complete map of all genetic modifications involved in prostate cancer.

"We have high hopes for the project to find new markers for diagnosis and new treatment approaches for prostate cancer," said Associate Professor (PD) Dr. Holger Sltmann of DKFZ, coordinator of the network. "Focusing our project on young patients is also very likely to produce findings about the causes of hereditary prostate cancer," says Professor Guido Sauter, Director of UKE's Institute of Pathology and co-coordinator of the research project. "Our long-standing collaborations with the project partners, which have been established primarily with the support of the Research Ministry, have created excellent conditions for this project," Sltmann confirms.

With more than 60,000 cases newly diagnosed each year just in Germany, prostate cancer is the most common tumor affecting men; each year, 10,000 men die from prostate cancer. As life expectancy is rising, these figures will dramatically increase over the years to come. Therefore, we urgently need new and better diagnostic methods for prostate cancer. Early detection of aggressive tumors and their discrimination from benign diseases of the prostate is crucial for determining the best possible treatment for each individual patient. Study participants were recruited from more than 2,000 prostate cancer patients undergoing surgery at UKE's Martini-Klinik every year. Martini-Klinik is the only hospital in Germany which specializes exclusively on prostate cancer. "More than 150 patients each year belong to the group of patients aged 50 or younger," says Dr. Thorsten Schlomm, Scientific Director of Martini-Klinik.

The molecular analysis of prostate cancer is not the only project participation of DKFZ in the International Cancer Genome Consortium. Coordinated by DKFZ, researchers from Heidelberg, Dusseldorf and Berlin have been working together in the "PedBrain" network since January 2010 to analyze th
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Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

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