Navigation Links
Uncovering lithium's mode of action
Date:5/21/2010

Though it has been prescribed for over 50 years to treat bipolar disorder, there are still many questions regarding exactly how lithium works. However, in a study appearing in this month's Journal of Lipid Research, researchers have provided solid evidence that lithium reduces brain inflammation by adjusting the metabolism of the health-protective omega-3-fatty acid called DHA.

Inflammation in the brain, like other parts of the body, is an important process to help the brain combat infection or injury. However, excess or unwanted inflammation can damage sensitive brain cells, which can contribute to psychiatric conditions like bipolar disorder or degenerative diseases like Alzheimers.

It's believed that lithium helps treat bipolar disorder by reducing brain inflammation during the manic phase, thus alleviating some of the symptoms. Exactly how lithium operates, though, has been debated.

Mireille Basselin and colleagues at the National Institute of Aging and University of Colorado, Denver, took a detailed approach to this question by using mass spectrometry analysis to analyze the chemical composition of brain samples of both control and lithium-treated rats stressed by brain inflammation.

They found that in agreement with some other studies, rats given a six-week lithium treatment had reduced levels of arachidonic acid and its products, which can contribute to inflammation.

In addition, they also demonstrated, for the first time, that lithium treatment increased levels of a metabolite called 17-OH-DHA in response to inflammation. 17-OH-DHA is formed from the omega-3 fatty acid DHA (docosahexaenoic acid) and is the precursor to a wide range of anti-inflammatory compounds known as docosanoids. Other anti-inflammatory drugs, like aspirin, are known to also enhance docosanoids in their mode of action.

Basselin and colleagues noted that the concentration of DHA did not increase, which suggests that lit
'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Uncovering the secrets of ulcer-causing bacteria
2. Uncovering secrets of life in the ocean
3. New climate change reports underscore need for action
4. Chemist stitches up speedier chemical reactions
5. AAPS presents therapeutic protein drug interactions workshop
6. MicroRNA network study implicates rewired interactions in cancer
7. Leptin action in the brain linked to sepsis survival
8. Cellcom Israel Ltd. Announces Dismissal of a Purported Class Action
9. Research pinpoints action of protein linked to key molecular switch
10. Key enzyme discovered to be master regulator in protein-protein reactions
11. Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... -- The Parenteral Drug Association (PDA) today confirmed that seven ... at least seven more will participate in the upcoming 2014 ... in Washington D.C. , Dec. 2-4. ... from the regulatory agencies in the United States ... effort to help advance the use of metrics in the ...
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3
... the glue that holds cells together also is involved in ... to spread to other parts of the body, researchers at ... Sept. 18 online issue of the Journal of Cell Biology, ... spread of cancer that makes the disease difficult to treat, ...
... deepened our understanding of the remarkable ability of some ... response to one's own actions and in response to ... perpetrated by another individual. This ability is thought to ... which have been hypothesized to contribute to skills such ...
... In their hunt for genes and proteins that explain how ... researchers began by testing whether mutant fruit flies prefer eating ... behavioral test, the researchers discovered that a single protein missing ... ignore caffeine's taste and consume the caffeine as if it ...
Cached Biology News:Two-faced protein can stop metastasis or promote it, researchers say 2Two-faced protein can stop metastasis or promote it, researchers say 3Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others 2Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others 3Mirrors in the mind: New studies elucidate how the brain reflects onto itself the actions of others 4Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine 2Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine 3
(Date:11/21/2014)... 19, 2014 The science of light ... shared with more than 200 primary students in a ... the University of Otago Physics Department and funded by ... students, members of the university’s OSA/SPIE Student Chapter visited ... September, giving children from small, rural schools hands-on lessons ...
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... SAN DIEGO , Nov. 20, 2014 /PRNewswire/ ... patient has been dosed in its Phase 1 ... and cisplatin for the treatment of malignant pleural ...  Polaris Group is conducting clinical trials on ADI-PEG ... other agents, for the treatment of several other ...
(Date:11/18/2014)... November 17, 2014 RPS Diagnostics ... tests – today announces its third annual partnership ... (CDC) Get Smart About Antibiotics Week from November ... a national campaign designed to highlight the coordinated ... and non-profit and for-profit partners to provide education ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3
... REYKJAVIK, Iceland, November 4 deCODE,genetics (Nasdaq: DCGN ... a,hearing before a Nasdaq Listing Qualifications Panel to ... Rule 4450(b)(1)(A), which,requires a minimum market value of ... deCODE received a Staff Determination Letter from The,Nasdaq ...
... - Oncothyreon Inc. (Nasdaq:,ONTY) (TSX:ONY), a biotechnology company ... the treatment of cancer, today,announced that Robert Kirkman, ... present at the Rodman & Renshaw Annual Global ... 11, 2008 at 11:35 a.m.,E.T., A live ...
... leading provider of,Business Process Management (BPM), Business ... for aligning strategy with execution,today announced that ... the premier global association for professionals involved ... acquisitions,selected Metastorm as an ACG Deal of ...
Cached Biology Technology:deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter 2deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter 3deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter 4Metastorm Selected as a Finalist in ACG Deal of the Year Awards 2
WIF-1 (N-20)...
... Gia-1. Strong reactivity ... bovine (74%) and guinea pig ... human (31%). Specificity confirmed ... Gat, rat Goa, rat Gia-1, ...
VEGF Receptor-2, phospho-specific (Tyr996)...
IgG2b, k APC clone A95-1, Isotype Rat IgG2b, kappa, 0.1 mg ....
Biology Products: