Navigation Links
Uncovering lithium's mode of action
Date:5/21/2010

Though it has been prescribed for over 50 years to treat bipolar disorder, there are still many questions regarding exactly how lithium works. However, in a study appearing in this month's Journal of Lipid Research, researchers have provided solid evidence that lithium reduces brain inflammation by adjusting the metabolism of the health-protective omega-3-fatty acid called DHA.

Inflammation in the brain, like other parts of the body, is an important process to help the brain combat infection or injury. However, excess or unwanted inflammation can damage sensitive brain cells, which can contribute to psychiatric conditions like bipolar disorder or degenerative diseases like Alzheimers.

It's believed that lithium helps treat bipolar disorder by reducing brain inflammation during the manic phase, thus alleviating some of the symptoms. Exactly how lithium operates, though, has been debated.

Mireille Basselin and colleagues at the National Institute of Aging and University of Colorado, Denver, took a detailed approach to this question by using mass spectrometry analysis to analyze the chemical composition of brain samples of both control and lithium-treated rats stressed by brain inflammation.

They found that in agreement with some other studies, rats given a six-week lithium treatment had reduced levels of arachidonic acid and its products, which can contribute to inflammation.

In addition, they also demonstrated, for the first time, that lithium treatment increased levels of a metabolite called 17-OH-DHA in response to inflammation. 17-OH-DHA is formed from the omega-3 fatty acid DHA (docosahexaenoic acid) and is the precursor to a wide range of anti-inflammatory compounds known as docosanoids. Other anti-inflammatory drugs, like aspirin, are known to also enhance docosanoids in their mode of action.

Basselin and colleagues noted that the concentration of DHA did not increase, which suggests that lit
'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Uncovering the secrets of ulcer-causing bacteria
2. Uncovering secrets of life in the ocean
3. New climate change reports underscore need for action
4. Chemist stitches up speedier chemical reactions
5. AAPS presents therapeutic protein drug interactions workshop
6. MicroRNA network study implicates rewired interactions in cancer
7. Leptin action in the brain linked to sepsis survival
8. Cellcom Israel Ltd. Announces Dismissal of a Purported Class Action
9. Research pinpoints action of protein linked to key molecular switch
10. Key enzyme discovered to be master regulator in protein-protein reactions
11. Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry ... new website design. "When we launched FindBiometrics 12 ... Peter O,Neill , founder and CEO of FindBiometrics. "Now it,s ... from the key players on a very broad scale.  We ...
(Date:1/22/2015)... Wis. , Jan. 15, 2015  BellBrook Labs, ... drug discovery, announced the launch of a TR-FRET ... the company,s Transcreener UDP Assay, a high throughput ... The new assay will allow for sensitive detection ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... Relatives of a young person who dies suddenly should ... order to identify if they too are at risk ... of the European Society of Human Genetics today (Tuesday ... a research fellow at the Department of Cardiogenetics, Academic ...
... some of our immune proteins into the inflammatory defenders they ... appear in the June 8 issue of the Journal ... by a team of researchers in Italy, also suggests that ... into risk factors for intestinal disorders. Parasite-driven selection ...
... TEMPE, Ariz. The International Institute for Species Exploration ... taxonomists scientists responsible for species exploration and classification ... in 2008. On the list are a pea-sized ... The top 10 new species also include the very ...
Cached Biology News:Comprehensive cardiogenetic testing for families of sudden unexplained death victims can save lives 2Immune genes adapt to parasites 2Scientists announce top 10 new species; issue SOS 2Scientists announce top 10 new species; issue SOS 3Scientists announce top 10 new species; issue SOS 4Scientists announce top 10 new species; issue SOS 5
(Date:3/3/2015)... FRANCISCO , March 3, 2015 Kindred Biosciences, ... on saving and improving the lives of pets, announced today ... financial results on March 12, 2015 after the market close. ... Eastern Time that day. Interested parties may ... US, or (484) 756-4262 internationally, and using conference ID 98449349.  ...
(Date:3/3/2015)... 03, 2015 Becht Engineering Co., ... it has acquired The CECON Group, Inc., located ... were not announced. , Becht Engineering (http://www.becht.com ... sector including oil and gas production, refining, petrochemical, ... nuclear power sectors. The company has twelve offices ...
(Date:3/3/2015)... Genedata, a leading provider of ... science research, today announced that Pfizer Inc. has ... use at Pfizer biopharma research and development sites ... Pfizer’s global deployment and roll out project at ... Innovation (CTI), and Pharmaceutical Sciences groups. , ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Cambridge Semantics, ... Semantic Web technology, today announced that it has been ... That Matter in Knowledge Management.’ , To create ... of colleagues, analysts and system integrators who identify organizations ... of the right information to the right people at ...
Breaking Biology Technology:Genedata Biologics Licensed by Pfizer Inc. 2Genedata Biologics Licensed by Pfizer Inc. 3Cambridge Semantics Named to KMWorld’s 2015 ‘100 Companies That Matter in Knowledge Management’ 2
... Rochelle, NY, February 8, 2011Successful intranasal delivery of ... Parkinson disease yielded significant improvement in motor function ... disease. These highly promising findings, reported in ... Mary Ann Liebert, Inc. highlight the potential for ...
... ST. LOUIS, Feb. 16, 2011 / PRNewswire/ ... announces the following executive leadership appointments intended to ... strategic plan. Frank Wicks, President Research, ... Research products, including those in Research Essentials, Research ...
... 16, 2011 Pneumococcus ( Streptococcus pneumoniae ) ... mortality in young children worldwide. While successful vaccines ... work against specific pneumococcal strains, with the risk ... Through a novel discovery approach, researchers at Children,s ...
Cached Biology Technology:Sigma-Aldrich Announces Organizational Changes 2Sigma-Aldrich Announces Organizational Changes 3New Pneumococcal Vaccine Approach Successful in Early Tests 2New Pneumococcal Vaccine Approach Successful in Early Tests 3New Pneumococcal Vaccine Approach Successful in Early Tests 4
... Array CGH Genomic Labeling Systems are a ... of genomic DNA samples for array-based Comparative ... and direct labeling formats, the BioPrime Plus ... flexible solution to your genomic labeling needs. ...
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
Biology Products: