Navigation Links
Uncooperative voltage sensors
Date:4/27/2009

The May 2009 issue of the Journal of General Physiology features an article and accompanying commentary on new experimental evidence that advances previous conclusions about the essential features of the Shaker K+ channel, a voltage-gated potassium (Kv) channel.

As Richard Horn (Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College) explains in his JGP commentary:

"Many of the essential features of the voltage-sensing mechanism are known [including consensus that], as in the original Hodgkin-Huxley model (Hodgkin and Huxley, 1952), all four of the channel's S4 [fourth transmembrane] segments must be in an activated conformation at a depolarized voltage before the channel can open. Part of the evidence for this assertion is that preventing the outward movement of only one S4 segment, by photocrosslinking it to a neighboring region, prevents Shaker 's activation gate from opening (Horn et al., 2000). Therefore, channel opening requires the participation of all four voltage sensors. This conclusion is furthered advanced by an article in this issue by Gagnon and Bezanilla (2009). These authors propose, and provide evidence, that if three of the voltage sensors in a channel are in a permanently activated conformation, the fourth voltage sensor can open and close the channel by itself."

In his conclusion, Horn explains that the technique employed by Gagnon and Bezanilla, in addition to other recent complementary techniques, "promises to unmask some of the previously inscrutable features of the allosteric communication among entwined Kv subunits and between the homologous domains of sodium channels."


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. New insight into the mechanisms of voltage sensing and transduction in biological processes
2. A London effort to develop point-of-care nanosensors for HIV diagnosis and monitoring
3. Researchers develop flow sensors based on hair structures of blind cavefish
4. Clemson researchers advance nano-scale electromechanical sensors
5. Photonic crystal biosensors detect protein-DNA interactions
6. Goulbourne earns NSF award to research heart stent sensors
7. Wearable Sensors Conceived at Harvard Robotics Lab Measure Hand Forces
8. New gas sensors for monitoring carbon dioxide sinks
9. New cell-based sensors sniff out danger like bloodhounds
10. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
Breaking Biology Technology: