Navigation Links
Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
Date:11/9/2010

en safe for clinical use. Given the size of nanoparticles spheres of around six millionths of an inch in diameter "Trojan Pony" may be a better metaphor.

A toxin derived from the substance bees insert into their victims when they sting is the agent that will destroy the sperm and HIV. The toxin, called melittin, comprises more than half of the dry weight of the venom of the honeybee Apis mellifera.

The nanoparticles will carry a synthetic version of the toxin melittin to the targets.

"Cells readily take in melittin," Wickline says. "But once it gets in, it pokes holes in cell membranes destroy the cells."

A local biotech startup company, Kereos Inc., is testing melittin as an anti-cancer agent.

Since melittin can annihilate almost any cell, the trick is to target the melittin to the specific cells intended for destruction (cancer, sperm, HIV) without causing collateral damage to other cells in the body.

Wickline and colleague Paul Schlesinger, MD, PhD, associate professor of cell biology and physiology, attacked that problem two years ago when they developed "nanobees," the name coined for nanoparticles that sequester melittin so that it neither harms healthy tissue nor is degraded before it reaches the intended target.

Wickline and his colleagues have also developed the ability to add agents to the nanobees to cause them to home in on specific target cells. Although nanoparticles are a few thousand times smaller than the dot above an "i," each can carry hundreds of thousands of molecules on its surface.

"We have the ability to attach and swap in various specific targeting molecules to nanoparticles that will bind with receptors on the surface of selected cells," Wickline says. "This gives the particles the ability to home in on specific target cells."

To get the nanobees to hook up with sperm and offload their lethal cargo, Wickline intends to target a well-known "docking site" on th
'/>"/>

Contact: Joni Westerhouse
westerhousej@wustl.edu
314-286-0120
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. GUMC to develop smoking cessation aids based on unconventional nicotine addiction theory
2. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
3. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
4. Triple-combo drug shows promise against antiviral-resistant H1N1, UAB researcher says
5. Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
6. Study: Excessive use of antiviral drugs could aid deadly flu
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. No more pills: Male contraceptive takes new approach
9. UNC researchers receive $100,000 Grand Challenges Exploration Grant to develop male contraceptive
10. Hormonal contraceptives associated with higher risk of female sexual dysfunction
11. Study explains potential failure of oral contraceptives with obese women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... with traumatic injuries have identified an immune marker ... a hospital-acquired infection. The study, led by clinician-scientists ... June in the journal Shock , is ... to the clinical implementation of quick-turnaround immune function ... system damage following critical illness or injury in ...
(Date:7/9/2014)... shark species may be able to cope with the rising ... , The Arctic today is best known for its tundra ... Roughly 53 to 38 million years ago during what is ... to a huge temperate forest with brackish water, home to ... creatures, crocodiles and giant tortoises. Much of what is known ...
(Date:7/9/2014)... U.S. may be on the verge of an economy driven ... cleaner than coal and is undergoing a production boom. It ... but recent research is casting serious doubts over just how ... & Engineering News (C&EN), the weekly news magazine of ... a senior correspondent at C&EN, explains that when burned as ...
Breaking Biology News(10 mins):Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3
... SLOVENIARidge and furrow rainwater-harvesting (RFRH) systems with mulches were ... northwest China to improve water availability and to increase ... rainwater harvesting zones, and bare or mulched furrows serve ... and are being promoted in many parts of the ...
... that can cope with sudden fluctuations in the weather could ... of plants. Scientists studying how tiny algae renew ... useful in developing crops suited to climates in which weather ... protein renewal takes place dictates how quickly they can adapt ...
... A manmade package filled with nature,s bone-building ingredients delivers ... bone injuries faster than products currently available, Cleveland researchers ... surgical elastic "implant device," essentially a wrapping that mimics ... growth factors and other natural components of the periosteum ...
Cached Biology News:Improved rainwater harvesting system promising 2It's all in the wrapping 2
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility ... of Product Strategy. In this role, Michelle will work with ... guide in the development of iLab products. Her main goal ... benefit to the scientific community by offering the most advanced, ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... - Tamiflu Remains Fully Effective ... Latest surveillance data coming through ... virologists and clinicians indicates that,the influenza A(H3N2) virus is ... on the data published by ECDC Roche confirms that ...
... Conn., Jan. 19 SurgiQuest, Inc. is pleased to ... agreement with Intuitive Surgical, Inc. (Nasdaq: ISRG ... system using AirSeal(TM) technology for use with Intuitive,s laparoscopic ... invasive surgical procedures because it allows the surgeon to ...
... Corporation,s (Amex: ETC ) ("ETC" or ... of two BARA-MED(R) XD Monoplace Hyperbaric Chambers for ... St. Luke,s Hospital - Allentown Campus is part ... a nationally recognized, regional, integrated network of non-profit ...
Cached Biology Technology:Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 2Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 3Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 4SurgiQuest Signs a Development and Supply Agreement with Intuitive Surgical for MIS Access Utilizing the AirSeal(TM) Technology 2Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 3Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 4
Goat polyclonal to Rabenosyn 5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: ELKHTLAKQKGGTD, corresponding to C terminal amino acids 771-784 of Human Rabenosyn 5. Entr...
Acetyl CoA Carboxylase Antibody...
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
AANAT [Arylalkylamine N-acetyltransferase; EC 2.3.1.87]...
Biology Products: