Navigation Links
Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
Date:11/9/2010

en safe for clinical use. Given the size of nanoparticles spheres of around six millionths of an inch in diameter "Trojan Pony" may be a better metaphor.

A toxin derived from the substance bees insert into their victims when they sting is the agent that will destroy the sperm and HIV. The toxin, called melittin, comprises more than half of the dry weight of the venom of the honeybee Apis mellifera.

The nanoparticles will carry a synthetic version of the toxin melittin to the targets.

"Cells readily take in melittin," Wickline says. "But once it gets in, it pokes holes in cell membranes destroy the cells."

A local biotech startup company, Kereos Inc., is testing melittin as an anti-cancer agent.

Since melittin can annihilate almost any cell, the trick is to target the melittin to the specific cells intended for destruction (cancer, sperm, HIV) without causing collateral damage to other cells in the body.

Wickline and colleague Paul Schlesinger, MD, PhD, associate professor of cell biology and physiology, attacked that problem two years ago when they developed "nanobees," the name coined for nanoparticles that sequester melittin so that it neither harms healthy tissue nor is degraded before it reaches the intended target.

Wickline and his colleagues have also developed the ability to add agents to the nanobees to cause them to home in on specific target cells. Although nanoparticles are a few thousand times smaller than the dot above an "i," each can carry hundreds of thousands of molecules on its surface.

"We have the ability to attach and swap in various specific targeting molecules to nanoparticles that will bind with receptors on the surface of selected cells," Wickline says. "This gives the particles the ability to home in on specific target cells."

To get the nanobees to hook up with sperm and offload their lethal cargo, Wickline intends to target a well-known "docking site" on th
'/>"/>

Contact: Joni Westerhouse
westerhousej@wustl.edu
314-286-0120
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. GUMC to develop smoking cessation aids based on unconventional nicotine addiction theory
2. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
3. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
4. Triple-combo drug shows promise against antiviral-resistant H1N1, UAB researcher says
5. Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
6. Study: Excessive use of antiviral drugs could aid deadly flu
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. No more pills: Male contraceptive takes new approach
9. UNC researchers receive $100,000 Grand Challenges Exploration Grant to develop male contraceptive
10. Hormonal contraceptives associated with higher risk of female sexual dysfunction
11. Study explains potential failure of oral contraceptives with obese women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Va. , Dec. 15, 2014 ... to make it easier to detect and prevent ... Today the agency started performing an ... capability will validate the authenticity of purchased microcircuits ... The new quality control measures will be conducted ...
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ... robust – with the clinical data to back it ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation ... is this more evident than at international borders. ... secure document scanners have allowed veteran travelers to ... Automated Passport Control (APC) Kiosks at an increasing ... the globe. According to ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... Intensive field work by researchers David General of the Palawan ... Museum of Comparative Zoology , Harvard University has led to the ... before in the Philippines. Another two new genera were discovered by ... as the 200th jubilee issue of the open access journal ...
... 2012 A study published in the June 2012 issue ... and Adolescent Psychiatry found that young children who have ... higher prevalence of mental health problems and that very few ... National Survey of Child and Adolescent Well-Being II (NSCAW II), ...
... in many parts of the world, but discarded fruit peel, ... use in the burgeoning field of nanotechnology according to research ... Punica Granatum, the pomegranate is native in northern India and ... since ancient times. The fruit extract is a rich source ...
Cached Biology News:An ant scientist's picnic: The highly diverse ant fauna of the Philippines 2Child welfare investigation predicts mental health problems in young children 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Representatives of Sentry Insurance are recruiting information ... open in the Fox Valley earlier next year. , ,The ... in the valley, citing a rich pool of talent in ... the central Wisconsin city to Appleton and other ...
... Technologies, Inc . has signed an agreement with an institutional ... private placement of convertible notes, and the company plans to ... to Third Wave, the notes are convertible into approximately 2.48 ... price of $6 per share. The notes carry a yield ...
... this month it wants to return to the moon - and ... Mars . Others say the National Aeronautics and Space ... head directly for the red planet, where there are tantalizing signs ... the business of space flight and let private entrepreneurs figure it ...
Cached Biology Technology:Flying to the moon? Take Wisconsin tech along 2Flying to the moon? Take Wisconsin tech along 3Flying to the moon? Take Wisconsin tech along 4
Rabbit polyclonal to Methionine Aminopeptidase 2 ( Abpromise for all tested applications). entrezGeneID: 10988 SwissProtID: P50579...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Mouse monoclonal [CP23] to Ricin communis ( Abpromise for all tested applications)....
Kinase Buffer can be used to assay protein kinase activity...
Biology Products: