Navigation Links
Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
Date:11/9/2010

A vaginal gel that affords both contraception and HIV protection using nanoparticles that carry bee venom is one of the bold, unconventional ideas that won a 2010 Grand Challenges Explorations grant from the Bill & Melinda Gates Foundation.

Grand Challenges Explorations is a Gates Foundation initiative to foster innovative projects in areas where unorthodox thinking is most urgently needed. Recipients receive grants to explore creative solutions to global health issues.

Sam Wickline, MD, professor of medicine, of cell biology and physiology, of physics and of biomedical engineering at Washington University School of Medicine in St. Louis is one of 65 scientists selected in November to participate in the grant program.

Wickline proposes to develop a contraceptive, antiviral gel containing trillions of nanoparticles that will target both HIV and sperm and deliver a bee venom toxin that will incapacitate them.

"Sperm and HIV (the human immunodeficiency virus that can lead to acquired immune deficiency syndrome, or AIDS) are remarkably similar in their natural mechanism of genetic transmission," Wickline says. "Both need to fuse with their target cell in order to deliver their genetic payloads DNA in the case of sperm, and RNA in the case of HIV."

Wickline's plan is to use the very means by which sperm and HIV operate to destroy them.

"The idea is to trick each to fuse with a synthetic Trojan Horse a nanoparticle that will overwhelm sperm and HIV in numbers and in destructive power."

It is an unconventional and creative plan for sure, but it is grounded in proven technologies and research-based knowledge. If the idea shows promise, the initial seed money grant can lead to additional funding.

The Trojan Horse or decoy that will be used to attract the sperm and HIV is a lipid nanoparticle created by Wickline and colleague Gregory Lanza, MD, PhD, professor of medicine, that has already been prov
'/>"/>

Contact: Joni Westerhouse
westerhousej@wustl.edu
314-286-0120
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. GUMC to develop smoking cessation aids based on unconventional nicotine addiction theory
2. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
3. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
4. Triple-combo drug shows promise against antiviral-resistant H1N1, UAB researcher says
5. Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
6. Study: Excessive use of antiviral drugs could aid deadly flu
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. No more pills: Male contraceptive takes new approach
9. UNC researchers receive $100,000 Grand Challenges Exploration Grant to develop male contraceptive
10. Hormonal contraceptives associated with higher risk of female sexual dysfunction
11. Study explains potential failure of oral contraceptives with obese women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 2014 Researchers have pioneered a revolutionary new ... technology, called Virtual Finger, allows scientists to move ... and synapses using the flat surface of their ... imaging studies orders of magnitude more efficient, saving ... across many areas of experimental biology. The software ...
(Date:7/11/2014)... type 1 can inhibit voltage-gated calcium channel, ... release. However, some scholars demonstrated that cannabinoid ... influx and increase neurotransmitter release. Dr. Yi ... to Tongji Medical College, Huazhong University of ... voltage-clamp and calcium imaging in cultured trigeminal ...
(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... Ore. -- New research has found that if you want ... or other cruciferous vegetables, you need to eat the real ... absorbed and of far less value if taken as a ... Pauling Institute at Oregon State University, is one of the ...
... has awarded UC Santa Barbara up to $15 million ... shape the future of technology in areas that will ... educate future scientists and engineers and advance the discovery ... novel polymers to next-generation microelectronics. The pioneering institute ...
... them, and although they could be effective in theory, antivirulence ... to be published in the online journal mBio ... to fight infection while avoiding the pitfalls of drug resistance. ... growth of pathogens, but antivirulence drugs prevent disease by ...
Cached Biology News:Health benefits of broccoli require the whole food, not supplements 2Health benefits of broccoli require the whole food, not supplements 3UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education 2UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education 3Can antivirulence drugs stop infections without causing resistance? 2
(Date:7/11/2014)... GENEVA , July 11, 2014 ... pleased to announce the appointment of John P. ... Campus Biotech   in  Geneva . ... on Campus Biotech in Geneva , ... internationally recognised neuroscientists. John P. Donoghue , founder ...
(Date:7/11/2014)... July 11, 2014 Cayenne Medical, ... specializing in the soft tissue reconstruction segment, announced ... System for surgeries involving the shoulder and extremities. ... a novel, inserter-controlled deployment method. The unique delivery ... deployment, anchor pull-out, or anchor displacement (also commonly ...
(Date:7/10/2014)... July 10, 2014 Deep Knowledge ... Medicine Forum on ‘Commercialising Longevity Research’ and welcomed ... to the London Bioscience Innovation Center for the ... and Aging Analytics Ltd. The meeting highlighted the ... translational research for age-related disease, as well as ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, and ... purchased a DNA test to unravel the ... a lifetime of memories, sharing, and closeness. In fact, ... genuinely brought the family closer together. , Recently, ... history and prior to taking the genetic ancestry ...
Breaking Biology Technology:John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... a bioMerieux company that develops innovative oncology diagnostic tests ... from a clinical study evaluating the company,s Breast Cancer ... the study were presented at the 33rd Annual CTRC-AACR ... The company also announced that the Breast Cancer Index ...
... 2010 Pfizer Inc. (NYSE: PFE ) ... it is voluntarily withdrawing Thelin® (sitaxentan) for the treatment ... is approved (the European Union, Canada and Australia).  In ... (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) Pfizer,s decision ...
... (Dec. 9, 2010) -- Nanotechnologists, marine biologists and signal-processing ... Woods Hole, Mass., and other U.S. universities have won ... Research to unlock the secrets of nature,s best camouflage ... emulate some of the elegant skin colors and patterns ...
Cached Biology Technology:bioTheranostics' Breast Cancer Index(SM) Predicts Risk for Late Recurrence in Early Stage ER-Positive Breast Cancer Patients 2bioTheranostics' Breast Cancer Index(SM) Predicts Risk for Late Recurrence in Early Stage ER-Positive Breast Cancer Patients 3Pfizer Stops Clinical Trials of Thelin® and Initiates Voluntary Product Withdrawal in the Interest of Patient Safety 2Pfizer Stops Clinical Trials of Thelin® and Initiates Voluntary Product Withdrawal in the Interest of Patient Safety 3Nano squid skin: DOD awards $6M for metamaterials research 2Nano squid skin: DOD awards $6M for metamaterials research 3
... Security ChemStation is a ... application for data acquisition, ... searching and reporting, addressing ... data security, integrity, and ...
... for genome-wide microRNA expression profiling and ... Paraflo microfluidic on-chip synthesis platform. These ... our comprehensive microRNA Expression Profiling Service. ... Mammals microRNA Microarray contains all known ...
... Ocean Optics LIBS2000+ Spectrometers (sold separately) in ... Ablation Chamber to offer numerous configuration options ... features include a high-power 1064 nm Nd:YAG ... X-Y sample positioning, laser spot diameter control ...
...
Biology Products: