Navigation Links
Uncharged organic molecule can bind negatively charged ions
Date:2/26/2008

d Li's solution was to create a donut-shaped organic molecule whose center would serve as the binding spot. A halide ion might fit snugly inside the hole, but the arrangement of atoms surrounding the hole would exclude any solutions.

Flood also wanted the synthesis of such a molecule to be cheap, easy and flexible, so he looked to the "click chemistry" devised by Scripps Research Institute chemist K. Barry Sharpless. Click chemistry is an efficient method of joining molecules together to form larger molecules. Flood's particular application of click chemistry results in an eight-member macrocycle with a 3.7 angstrom hole in the middle. The more-or-less symmetrical molecule that Flood and Li built contains four triazole rings sporting three nitrogen atoms each. It is presumed the nitrogens withdraw electron density from the carbon and hydrogen atoms closest to the molecule's hole, thereby creating an alluring binding spot for fluorine or chlorine ions. This binding is made all the more orderly because the macrocycle is preorganized to host its anionic guest.

"This thing is so easy to make," Flood said. "The triazole moiety has got more character to it than meets the eye. It's not just a byproduct of the click chemistry. We see lots of potential in it."

The other four members of Flood and Li's eight-member ring are entirely substitutable. Modifying these may give the chelator different binding affinities for a given anion.


'/>"/>

Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Is it organic or not?
2. Study reveals that nitrogen fertilizers deplete soil organic carbon
3. Surprise in the organic orchard -- a healthier worm in the apple
4. New microsensor measures volatile organic compounds in water and air on-site
5. Stanford researchers make first direct observation of 3-D molecule folding in real time
6. Rice scientists make breakthrough in single-molecule sensing
7. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
8. New book presents methods to poke and prod individual molecules
9. Curry-derived molecules might be too spicy for colorectal cancers
10. NIH recognizes Clemson nanotechnology for molecule tracking
11. New technique reveals subtle force-induced changes in biomolecules conformation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Uncharged organic molecule can bind negatively charged ions
(Date:4/1/2015)... , April 1, 2015   Medisafe ™, the ... users across iOS and Android ... integrating biofeedback into the platform to allow patients to ... For the first time, patients will be able to ... dose impacts important biometrics, such as glucose levels and ...
(Date:3/31/2015)... --  Guidepoint , a leading global research services firm, ... TRACKER, part of the Guidepoint TRACKER suite ... device and therapeutics markets. The Post-Surgical Pain Management TRACKER ... share, and adoption rates across three major modalities used ... The Post-Surgical Pain Management TRACKER will provide length ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... hard to come by, a University of Central Florida and ... National Institutes of Health highly competitive grants for hemophilia research. ... is aimed at determining whether a green technique pioneered at ... The second grant worth $2 million for four years is ...
... The Newark College of Engineering (NCE) at NJIT has been ... one of 20 universities and colleges across the nation in ... programs. This selection is the culmination of a ... Associate Dean Lisa Axe. Currently, some 43 percent ...
... out of the lab for a test drive with ... new way to develop possible future scenarios. James ... Center for Systems Integration and Sustainability (CSIS) and now ... London, has paired the relatively new use of agent-based ...
Cached Biology News:Hemophilia research gets NIH boost to a tune of $5.5 million 2Hemophilia research gets NIH boost to a tune of $5.5 million 3NSF funds NJIT's participation in program to retain engineering students 2Engaging land-use stakeholders is model behavior 2
(Date:4/23/2015)... Six startups from Russia traveled ... as part of the U.S.-Russia Innovation Corridor (USRIC) ... biotechnology startups to participate in the program since ... the University of Maryland (UMD) signed a Memorandum ... universities in the biomedical industry in 2013. , ...
(Date:4/23/2015)... Calif. , April 23, 2015  Cryoport, ... advanced cryogenic logistics solutions for the life sciences ... established its cryogenic logistics solutions within the animal ... with Yancey Farms to support the shipment of ... German Sport horse Stallions. Animal ...
(Date:4/23/2015)... Proove Biosciences , a commercial ... to announce the launch of Proove Non-Opioid ... 62 genetic variations to predict good versus poor ... non-opioid pain medications, namely ibuprofen (brand name Advil, ... Xanax) and acetaminophen (brand name Tylenol). , ...
(Date:4/23/2015)... 23, 2015 ReliantHeart's HeartAssist5® Ventricular Assist ... flow through the device) in real time, and this ... world’s leading provider of Machine to Machine (M2M) communications ... Flow via VADLink.com can be monitored by ... drop in flow below a minimum threshold, the patient ...
Breaking Biology Technology:U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3
... Palatin Technologies,Inc. (Amex: PTN ) will announce ... 9, 2007 before the open of the U.S. financial,markets. ... live audio webcast,hosted by Palatin,s executive management team on ... of operations in greater detail and provide,an update on ...
... 5 Exelixis,Inc. (Nasdaq: EXEL ) today ... 30, 2007. Revenues for the quarter ended ... million for the comparable period in 2006. The ... due to revenue recognition,associated with new collaboration agreements ...
... patients in over 30 states on ... options since 1997, DEERFIELD, Ill., Nov. 5 ... Kidney Patient,Educator (KPE) program, an ambitious project that has ... treatment options to,nearly 80,000 kidney disease patients in over ...
Cached Biology Technology:Palatin Technologies to Report Fiscal Year 2008 First Quarter Results; Teleconference and Webcast on November 9, 2007 2Exelixis Announces Third Quarter 2007 Financial Results and Business Update 2Exelixis Announces Third Quarter 2007 Financial Results and Business Update 3Exelixis Announces Third Quarter 2007 Financial Results and Business Update 4Exelixis Announces Third Quarter 2007 Financial Results and Business Update 5Exelixis Announces Third Quarter 2007 Financial Results and Business Update 6Exelixis Announces Third Quarter 2007 Financial Results and Business Update 7Exelixis Announces Third Quarter 2007 Financial Results and Business Update 8Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 2Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 3Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 4
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
...
A camera based compact unit for high speed scanning of 2D barcoded tubes in a cluster rack. This reader has been designed to read both 96 and 48 tube rack configurations and be compatible with common...
Biology Products: