Navigation Links
Uncharged organic molecule can bind negatively charged ions
Date:2/26/2008

d Li's solution was to create a donut-shaped organic molecule whose center would serve as the binding spot. A halide ion might fit snugly inside the hole, but the arrangement of atoms surrounding the hole would exclude any solutions.

Flood also wanted the synthesis of such a molecule to be cheap, easy and flexible, so he looked to the "click chemistry" devised by Scripps Research Institute chemist K. Barry Sharpless. Click chemistry is an efficient method of joining molecules together to form larger molecules. Flood's particular application of click chemistry results in an eight-member macrocycle with a 3.7 angstrom hole in the middle. The more-or-less symmetrical molecule that Flood and Li built contains four triazole rings sporting three nitrogen atoms each. It is presumed the nitrogens withdraw electron density from the carbon and hydrogen atoms closest to the molecule's hole, thereby creating an alluring binding spot for fluorine or chlorine ions. This binding is made all the more orderly because the macrocycle is preorganized to host its anionic guest.

"This thing is so easy to make," Flood said. "The triazole moiety has got more character to it than meets the eye. It's not just a byproduct of the click chemistry. We see lots of potential in it."

The other four members of Flood and Li's eight-member ring are entirely substitutable. Modifying these may give the chelator different binding affinities for a given anion.


'/>"/>

Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Is it organic or not?
2. Study reveals that nitrogen fertilizers deplete soil organic carbon
3. Surprise in the organic orchard -- a healthier worm in the apple
4. New microsensor measures volatile organic compounds in water and air on-site
5. Stanford researchers make first direct observation of 3-D molecule folding in real time
6. Rice scientists make breakthrough in single-molecule sensing
7. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
8. New book presents methods to poke and prod individual molecules
9. Curry-derived molecules might be too spicy for colorectal cancers
10. NIH recognizes Clemson nanotechnology for molecule tracking
11. New technique reveals subtle force-induced changes in biomolecules conformation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Uncharged organic molecule can bind negatively charged ions
(Date:8/28/2014)... for delivering compounds that could positively impact ... may be possible, thanks to researchers in ... semi-soft vaginal suppository made from the seaweed-derived ... antiviral drug Tenofovir provides a woman-initiated, drug-delivery ... of sexually transmitted infections during unprotected heterosexual ...
(Date:8/28/2014)... will be built worldwide by 2050. Many of these ... bring an influx of destructive loggers, hunters and illegal ... a ,global roadmap, for prioritising road building across the ... development and environmental protection. , The map has two ... of ecosystems and a ,road-benefits, layer that estimates the ...
(Date:8/28/2014)... needed to ensure safeguards are in place to protect ... ONE , researchers from Monash University, Stellenbosch University and ... from different studies - to look at the past ... whether they actually protect biodiversity. , Dr Bernard ... from human exploitation made common sense, however, up until ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Protected areas proven to protect biodiversity 2
... 2010 (Vienna, Austria) The International AIDS Society (IAS) ... awards, to be presented at plenary sessions during the ... IAS and partners, these awards recognize scientists involved in ... quality of work represented by the 2010 awardees is ...
... how plants grow, reproduce and communicate? Hundreds of international ... Cornell to McGill and the University of Montreal, are ... green: Plant Biology 2010. Media are welcome to attend ... Joint Annual Meetings of American Society of Plant Biologists ...
... It may sound counterintuitive, but LSU Associate Professor of ... the ways organic materials found in the environment, including soils, ... National Science Foundation, or NSF, was so impressed with his ... most prestigious awards the NSF CAREER award. "One of ...
Cached Biology News:International AIDS Society and partners recognize outstanding researchers from around the world at AIDS 2010 2International AIDS Society and partners recognize outstanding researchers from around the world at AIDS 2010 3Flowers do it, trees do it: Symposium on plant reproduction 2LSU researcher looks for new ways to keep a dirty situation clean 2LSU researcher looks for new ways to keep a dirty situation clean 3
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the six months ended June 30, 2014. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... , Announced top-line results related to the eight ... enrolled in the Phase 2 iDEAL Study evaluating ...
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 ... ones in the biotech start-up dense realm of Boston-Cambridge, ... alliances and able investors. James Sherley, the Director of ... made increasing the local and national visibility of his ... in September 2013. , In addition to a social ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company to ... asks food processors and food handling professionals to prepare ... currently using to Best Sanitizers’ Alpet® E3 Plus ... fighting cross-contamination and the spread of pathogens in the ... key criteria that make a hand sanitizer most effective, ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... - Mikael Dohlsten, M.D., Ph.D., To Succeed As President, ... Wyeth (NYSE: WYE ),today announced that Robert R. ... and Senior Vice President, Wyeth, later this,year. He will ... Ruffolo joined Wyeth in November 2000 and has been ...
... Intense global competition,and today,s networked economy have been ... the strategy of the next century. A,strategic alliance ... be sustainable and,mutually beneficial., How to build ... Forging,Partnerships That Work is a roadmap to successful ...
... /PRNewswire/ - ImmunoVaccine Technologies Inc. (IVT),a vaccine development ... vaccine delivery system used to increase the efficacy ... to protect the,DepoVax(TM) concept., "The results from ... with a single dose," remarked Marc Mansour, vice,president ...
Cached Biology Technology:Wyeth Research Head Robert R. Ruffolo, Jr., Ph.D., Announces Retirement 2Biopharmaceutical Alliances: Forging Partnerships That Work 2ImmunoVaccine Technologies Patents DepoVax(TM) Vaccine Platform 2
...
CQCS kit for etra KR 4i , (other units)....
... The inductive drives of VARIOMAG Magnetic ... as motors, belts, or mechanical bearings, making ... In addition, the VARIOMAG inductive drive can ... water, dust or microorganisms. This is why ...
... Fluoroskan Ascent FL ... fluorometric and luminometric measurement ... long list of advanced ... and Luminoskan Ascent. Fluoroskan ...
Biology Products: