Navigation Links
Uncharged organic molecule can bind negatively charged ions
Date:2/26/2008

d Li's solution was to create a donut-shaped organic molecule whose center would serve as the binding spot. A halide ion might fit snugly inside the hole, but the arrangement of atoms surrounding the hole would exclude any solutions.

Flood also wanted the synthesis of such a molecule to be cheap, easy and flexible, so he looked to the "click chemistry" devised by Scripps Research Institute chemist K. Barry Sharpless. Click chemistry is an efficient method of joining molecules together to form larger molecules. Flood's particular application of click chemistry results in an eight-member macrocycle with a 3.7 angstrom hole in the middle. The more-or-less symmetrical molecule that Flood and Li built contains four triazole rings sporting three nitrogen atoms each. It is presumed the nitrogens withdraw electron density from the carbon and hydrogen atoms closest to the molecule's hole, thereby creating an alluring binding spot for fluorine or chlorine ions. This binding is made all the more orderly because the macrocycle is preorganized to host its anionic guest.

"This thing is so easy to make," Flood said. "The triazole moiety has got more character to it than meets the eye. It's not just a byproduct of the click chemistry. We see lots of potential in it."

The other four members of Flood and Li's eight-member ring are entirely substitutable. Modifying these may give the chelator different binding affinities for a given anion.


'/>"/>

Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Is it organic or not?
2. Study reveals that nitrogen fertilizers deplete soil organic carbon
3. Surprise in the organic orchard -- a healthier worm in the apple
4. New microsensor measures volatile organic compounds in water and air on-site
5. Stanford researchers make first direct observation of 3-D molecule folding in real time
6. Rice scientists make breakthrough in single-molecule sensing
7. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
8. New book presents methods to poke and prod individual molecules
9. Curry-derived molecules might be too spicy for colorectal cancers
10. NIH recognizes Clemson nanotechnology for molecule tracking
11. New technique reveals subtle force-induced changes in biomolecules conformation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Uncharged organic molecule can bind negatively charged ions
(Date:1/22/2015)... man-made form of insulin delivered by nasal spray may ... with mild cognitive impairment and Alzheimer,s disease dementia, according ... Forest Baptist Medical Center. The study,s subjects ... (MCI) or mild to moderate Alzheimer,s dementia (AD). Those ...
(Date:1/22/2015)... ROBERTS, Washington , January 20, 2015 ... and tech stocks, releases video from the CES 2015 (Consumer ... consultant Apollo Robbins . Apollo shows how ... biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... (GPI) will bestow its 2013 Education Award on Mary Ann ... name, citing her work in educating patients, researchers, and the ... medical research journalism. Ms. Liebert is the president ... media empire known for establishing authoritative peer-reviewed journals in promising ...
... people so indelibly that their children are affected. ... and starvation, whose children experience altered physiology. ... Emory University have found an instance of animals ... experience to their offspring. That information comes not ...
... JOLLA, CA---- A new approach to mapping how proteins ... for Biological Studies, could aid in the design of ... By reengineering proteins using artificial amino acids, the Salk ... ,switch and its ligand, the molecule that turns it ...
Cached Biology News:Mary Ann Liebert to receive award for stem cell education at World Stem Cell Summit in San Diego 2Mice can inherit learned sensitivity to a smell 2Mice can inherit learned sensitivity to a smell 3Salk scientists crack riddle of important drug target 2Salk scientists crack riddle of important drug target 3
(Date:2/26/2015)... Calif. , Feb. 26, 2015   Regulus ... biopharmaceutical company leading the discovery and development of innovative ... Xanthopoulos , Ph.D., President and Chief Executive Officer of ... and Company 35 th Annual Healthcare Conference on ... conference is being held at the Boston Marriott Copley ...
(Date:2/26/2015)... CA (PRWEB) February 26, 2015 The ... online demonstration to support life extension technologies and awareness. ... UTC, Universal Coordinated Time, on March 21st 2015, in ... world. , Eric Schulke, Founder of MILE, says, ... act with urgency. The Movement for Indefinite Life Extension ...
(Date:2/26/2015)... MOUNTAIN VIEW, Calif. , Feb. 26, 2015 ... you navigate this ever-changing arena, Frost & Sullivan will host ... Frost & Sullivan Executive MindXchange , March 8 to 10, ... San Diego, Calif. This event ... and connected healthcare leaders to discuss industry disruptions and how ...
(Date:2/26/2015)... Already well respected for accuracy, HEIDENHAIN ... its Length Gauge offerings with new variants of its ... Specifically, HEIDENHAIN’s pencil probe-style SPECTO length gauge series now ... new 1Vpp, 12mm stroke length variants of the SPECTO ... a variant with a weak spring, 0.4N of gauging ...
Breaking Biology Technology:Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3Embrace the Future of Medical Technologies with Frost & Sullivan 2Embrace the Future of Medical Technologies with Frost & Sullivan 3Accuracy and Versatile Gauging Go Hand in Hand at HEIDENHAIN 2
... , , ... are a new cell-growth matrix that dramatically increase yields in packed-bed ... bottles and bags. New Brunswick,Scientific offers two new devices that use ... disposable culture system that outperforms spinners, T-flasks and roller bottles, and ...
... , ... to their application in cell culture and fermentation. ... particular antibody or antigen from a sample (from,serum, for example) by adding the corresponding ... Nonspecific adherence of substances in solution or suspension, ...
... Stevens, Ph.D. , Use ... Scott Stevens, Ph.D ., assistant professor of molecular genetics and ... University Station, #A4800,2500 Speedway,Austin,TX , 78712-1095,512.232.4303, , ... scott.stevens@mail.utexas.edu. , ...
Cached Biology Technology:A technique for increasing yields in bioreactors and disposable cell-culture systems 2A technique for increasing yields in bioreactors and disposable cell-culture systems 3A technique for increasing yields in bioreactors and disposable cell-culture systems 4Glossary for The BioPharm Guide to Fermentation and Cell Culture 2Glossary for The BioPharm Guide to Fermentation and Cell Culture 3Glossary for The BioPharm Guide to Fermentation and Cell Culture 4Glossary for The BioPharm Guide to Fermentation and Cell Culture 5Glossary for The BioPharm Guide to Fermentation and Cell Culture 6Glossary for The BioPharm Guide to Fermentation and Cell Culture 7Glossary for The BioPharm Guide to Fermentation and Cell Culture 8Glossary for The BioPharm Guide to Fermentation and Cell Culture 9Glossary for The BioPharm Guide to Fermentation and Cell Culture 10Glossary for The BioPharm Guide to Fermentation and Cell Culture 11Glossary for The BioPharm Guide to Fermentation and Cell Culture 12Glossary for The BioPharm Guide to Fermentation and Cell Culture 13Glossary for The BioPharm Guide to Fermentation and Cell Culture 14Glossary for The BioPharm Guide to Fermentation and Cell Culture 15Glossary for The BioPharm Guide to Fermentation and Cell Culture 16Fermentation Cell Culture: University Style 2Fermentation Cell Culture: University Style 3Fermentation Cell Culture: University Style 4Fermentation Cell Culture: University Style 5Fermentation Cell Culture: University Style 6Fermentation Cell Culture: University Style 7Fermentation Cell Culture: University Style 8Fermentation Cell Culture: University Style 9