Navigation Links
Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimer's disease
Date:3/26/2008

Tampa, FL (March 26, 2008) Targeted immune suppression using human umbilical cord blood cells may improve the pathology associated with Alzheimers disease, a new study in a mouse model of this currently untreatable neurodegenerative condition reports. The study, led by researchers at the University of South Florida, is published online in the peer-reviewed journal Stem Cells and Development (www.liebertpub.com/scd).

Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimers-like disease, the amount of amyloid- and -amyloid plaques -- hallmarks of Alzheimers pathology in the brain -- was reduced 62 percent. Amyloid- induces an inflammatory response in the brain associated with the interaction of CD40 and CD40L, two pro-inflammatory molecules. Researchers also reported an astonishing 86-percent improvement in cerebral amyloid angiopathy (CAA), another hallmark of Alzheimers disease. CAA compromises the integrity of the blood-brain barrier, disrupting normal trafficking of various molecules and cells from and to the brain and is believed to be the main culprit for the brain inflammation observed in Alzheimers.

Human umbilical cord blood cell therapy appeared to suppress CD40-CD40L activity, suggesting that this therapeutic approach offers the potential to target the pathogenic inflammatory response that contributes to Alzheimers disease and other degenerative conditions.

Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), Saneron CCEL Therapeutics (Tampa, FL), and Saitama Medical School (Japan), concluded that human umbilical cord blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the brain associated with Alzheimers disease.

It has been well documented that altered immune functioning, characterized by the p
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Umbilical cord blood cell therapy in an animal model of Alzheimers disease
2. Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice
3. Diabetes makes it hard for blood vessels to relax
4. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
5. High blood pressure in older adults traced to genes effects in blood vessels
6. Eltrombopag effective for hepatitis C patients with low blood-platelet counts
7. MIT works toward engineered blood vessels
8. Blood pressure drug telmisartan shows powerful activity against stroke
9. Protein controls blood vessel formation, offers new drug target
10. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
11. Study of malaria parasite in patient blood finds distinct physiological states
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the ... Business Report" report to their offering. This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ...
(Date:3/23/2015)... 2015   HOYOS Labs , a leading global ... that the Company will demonstrate multiple biometrics-based technologies under ... at Connect:ID on March 23 through 25, 2015, in ... highlight the IEEE Biometric Open Protocol Standard; free biometrics-based ... access control system. BOPS was invented by HOYOS Labs ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... , This release is available in Spanish ... at the Institute for Research in Biomedicine (IRB Barcelona), reveal ... the one known to date. Found in the cell membrane, ... of genes that make the cell divide, grow, migrate, specialise ...
... Helicobacter pylori , a bacterium found in about 50% of ... cancer. In an article for F1000 Medicine Reports , Seiji ... pylori infections Infection by the H. pylori ... do not have symptoms, but many develop problems including stomach ulcers. ...
... of Minnesota have created a molecular image of a system ... a breakthrough for biology and could provide insights to minimize ... electricity around the country. The research, led by ... Sciences, is published in the March 12 issue of ...
Cached Biology News:Opposing functions of a key molecule in the development of organisms 2Opposing functions of a key molecule in the development of organisms 3Preventing gastric cancer with antibiotics 2U of Minnesota researcher discovers how electricity moves through cells 2
(Date:4/16/2015)... South San Francisco, CA (PRWEB) April 16, 2015 ... it is scheduled to report first quarter results on ... Following the announcement, Cytokinetics’ senior management will host a ... operational and financial results and the company’s outlook for ... webcast and can be accessed from the homepage and ...
(Date:4/16/2015)... 16, 2015 Proove Biosciences , ... of BIO Contest for the 2015 BIO International ... 2015 BIO International Convention will take place June 15-18 ... the Buzz of BIO contest, industry leaders will be ... at the conference. The community voting period began on ...
(Date:4/16/2015)... IL (PRWEB) April 16, 2015 Regis ... the American Association for Cancer Research (AACR) annual meeting. ... Pennsylvania Convention Center, starting Saturday, April 18, in Philadelphia ... holds claim to title of the oldest and largest ... provides fellowships and grants, and partners with survivors to ...
(Date:4/16/2015)... OncoTAb, Inc., a ... spin-out company, announced today the appointment of physician ... Chief Operating Officer (COO). Cooper brings to OncoTAb ... clinical diagnostic and biotechnology platforms in the fields ... extensive career transcends the field of medical and ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2OncoTAb Names Dr. David L. Cooper as COO 2
... by a group at the University of Maryland (UMd), ... research and an age-old metallurgy technique to produce an ... class of sensors and micromechanical devices controlled by magnetism.* ... notable, among other things, for not using rare-earth elements ...
... Nov. 23, 2011  Puma Biotechnology, Inc., a development stage ... the Company completed the second tranche of its $60 ... October 5, 2011, Puma sold approximately 14.7 million shares ... purchase price of $3.75 per share, resulting in gross ...
... Modern Mobility Aids, Inc. (OTCBB: MDRM) (the "Company") ... financing required to execute its closing agreement to acquire ... ("LumiGene"). Modern Mobility Aids, Inc. is a ... and development in the Bio-Pharma sector as well as ...
Cached Biology Technology:New magnetic-field-sensitive alloy could find use in novel micromechanical devices 2Puma Biotechnology Announces Completion of Private Placement 2Puma Biotechnology Announces Completion of Private Placement 3Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 2Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 3
PMM2 Immunogen: PMM2 (NP_000294, 47 a.a. ~ 112 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
HOXC11 Antibody...
Rabbit polyclonal to Raf1 ( Abpromise for all tested applications). entrezGeneID: 5894 SwissProtID: P04049...
Sheep polyclonal to hCG beta core fragment ( Abpromise for all tested applications). Antigen: Full length native protein (purified) from human urine. Entrez GeneID: 1082 Swiss Protein ID...
Biology Products: