Navigation Links
Umbilical cord blood cell therapy in an animal model of Alzheimer's disease
Date:3/26/2008

New Rochelle, NY, March 26, 2008A novel strategy based on targeted immune suppression using human umbilical cord blood cells may improve the pathology and cognitive decline associated with Alzheimers disease, based on the results of a study in a mouse model of this currently untreatable neurodegenerative condition, as described in a groundbreaking report in Stem Cells and Development (www.liebertpub.com/scd), a peer-reviewed journal published by Mary Ann Liebert, Inc (www.liebertpub.com). The paper will be available free online (http://www.liebertonline.com/toc/scd/0/0).

Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimers-like disease, the amount of amyloid- and -amyloid plaqueshallmarks of Alzheimers pathology in the brainwas markedly reduced. Amyloid- induces an inflammatory response in the brain associated with the interaction of CD40 and CD40L, two pro-inflammatory molecules.

Human umbilical cord blood cell therapy was associated with suppression of CD40-CD40L activity, suggesting that this therapeutic approach modulates the activity of the immune system, offering the potential to target the pathogenic inflammatory response that may contribute to a variety of degenerative conditions, including Alzheimers disease.

Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), Saneron CCEL Therapeutics (Tampa, FL), and Saitama Medical School (Japan), concluded that human umbilical cord blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the brain associated with Alzheimers disease in a report entitled, Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Page: 1 2

Related biology news :

1. Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice
2. Diabetes makes it hard for blood vessels to relax
3. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
4. High blood pressure in older adults traced to genes effects in blood vessels
5. Eltrombopag effective for hepatitis C patients with low blood-platelet counts
6. MIT works toward engineered blood vessels
7. Blood pressure drug telmisartan shows powerful activity against stroke
8. Protein controls blood vessel formation, offers new drug target
9. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
10. Study of malaria parasite in patient blood finds distinct physiological states
11. Blood clotting protein linked to rheumatoid arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... the Department of Energy,s Oak Ridge National Laboratory ... R&D Magazine in recognition of the year,s top ... tremendous value of our National Labs," said Secretary ... the National Labs continues to help our nation ... and technological innovations necessary to remain globally competitive." ...
(Date:7/11/2014)... Mills Canyon fire started near the City of Entiat ... local resources, the fire quickly grew to over 1,000 ... of the fire is under investigation by the Washington ... working with existing local resources in developing fire control ... Service (USFS), Washington State Department of Natural Resources, (WA ...
(Date:7/11/2014)... Chicago is creating a new professorship in tissue ... Institute for Molecular Engineering and the Marine Biological ... the Millicent and Eugene Bell Foundation., The Eugene ... the Institute for Molecular Engineering. That endowed chair ... the MBL,s Eugene Bell Center for Regenerative Biology ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4New professorship in tissue engineering links molecular engineering, marine biology 2
... The Asian Cancer Research Group (ACRG)an independent, ... Merck (known as MSD outside the United States ... world,s largest genomics organizationtoday announced the publication of ... hepatitis B virus (HBV) integration in hepatocellular carcinoma ...
... Organic Electronics research group at Linkping University previously developed ... ions, as well as biomolecules. Tybrandt has now succeeded ... a similar way to traditional silicon-based electronics. ... carrier consists of chemical substances with various functions. This ...
... are retreating rapidly with the ongoing global climate change. But ... glaciers can recuperate within a short timeframe if temperatures are ... Danish aerial photos combined with both old and modern satellite ... created international attention and have been published as a cover ...
Cached Biology News:ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration 2ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration 3Old aerial photos supply new knowledge on glaciers in Greenland 2Old aerial photos supply new knowledge on glaciers in Greenland 3
(Date:7/10/2014)... OMICS Group’s 5th International conference and ... 2014 at Double Tree by Hilton Beijing, China is ... Analytical & Bioanalytical research methods only to facilitate improved ... occasion, Dr. Srinubabu Gedela, MD of OMICS Group Inc ... remarkable one in bringing a unique and international mix ...
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... HILL, N.C., April 10 Thought leaders ... Depot, Qualcomm,Nationwide and others will address new ... in today,s competitive economy at the 10th,Annual ... & Retaining Top Talent, sponsored by Best ...
... N.J., April 10 Pharmacopeia,(Nasdaq: PCOP ), ... novel,small molecule therapeutics, today announced that Leslie J. ... Officer and a member of the,Board of Directors ... was,effective April 9, 2008., Joseph A. Mollica, ...
... Thermo Fisher,Scientific Inc. (NYSE: TMO ) announced that ... of 2008 before the market opens on Thursday,April 24, ... same day at 9:00,a.m. Eastern Time., During the ... as well as future expectations. To listen, call (866) ...
Cached Biology Technology:Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry 2Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 2Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 3Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 4Thermo Fisher Scientific to Hold Earnings Conference Call on Thursday, April 24, 2008 2
The Proteome Profiler Human Phospho-MAPK Array Kit contains 4 membranes - each spotted in duplicate with 23 different MAPK antibodies....
Mycoplasma tested...
Recombinant Human PTP1B (aa 2-321), CF...
Request Info...
Biology Products: