Navigation Links
Ultrasound, nanoparticles may help diabetics avoid the needle
Date:11/21/2013

A new nanotechnology-based technique for regulating blood sugar in diabetics may give patients the ability to release insulin painlessly using a small ultrasound device, allowing them to go days between injections rather than using needles to give themselves multiple insulin injections each day. The technique was developed by researchers at North Carolina State University and the University of North Carolina at Chapel Hill.

"This is hopefully a big step toward giving diabetics a more painless method of maintaining healthy blood sugar levels," says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill.

The technique involves injecting biocompatible and biodegradable nanoparticles into a patient's skin. The nanoparticles are made out of poly(lactic-co-glycolic) acid (PLGA) and are filled with insulin.

Each of the PLGA nanoparticles is given either a positively charged coating made of chitosan (a biocompatible material normally found in shrimp shells), or a negatively charged coating made of alginate (a biocompatible material normally found in seaweed). When the solution of coated nanoparticles is mixed together, the positively and negatively charged coatings are attracted to each other by electrostatic force to form a "nano-network." Once injected into the subcutaneous layer of the skin, that nano-network holds the nanoparticles together and prevents them from dispersing throughout the body.

The coated PLGA nanoparticles are also porous. Once in the body, the insulin begins to diffuse from the nanoparticles. But the bulk of the insulin doesn't stray far it is suspended in a de facto reservoir in the subcutaneous layer of the skin by the electrostatic force of the nano-network. This essentially creates a dose of insulin that is simply waiting to be delivered into the bloodstream.

When a patient has type 1 or advanced type 2 diabetes, his or her body needs additional insulin, a hormone that transports glucose or blood sugar from the bloodstream into the body's cells. These diabetes patients must inject insulin as needed to ensure their blood sugar levels are in the "normal" range. However, these injections can be painful.

Using the new technology developed by Gu's team, a diabetes patient doesn't have to inject a dose of insulin it's already there. Instead, patients can use a small, hand-held device to apply focused ultrasound waves to the site of the nano-network, painlessly releasing the insulin from its de facto reservoir into the bloodstream.

The researchers believe the technique works because the ultrasound waves excite microscopic gas bubbles in the tissue, temporarily disrupting nano-network in the subcutaneous layer of the skin. That disruption pushes the nanoparticles apart, relaxing the electrostatic force being exerted on the insulin in the reservoir. This allows the insulin to begin entering the bloodstream a process hastened by the effect of the ultrasound waves pushing on the insulin.

"We know this technique works, and we think this is how it works, but we are still trying to determine the precise details," says Dr. Yun Jing, an assistant professor of mechanical engineering at NC State and co-corresponding author of the paper.

When the ultrasound is removed, the electrostatic force reasserts itself and pulls the nanoparticles in the nano-network back together. The nanoparticles then diffuse more insulin, refilling the reservoir.

"We've done proof-of-concept testing in laboratory mice with type 1 diabetes," Gu says. "We found that this technique achieves a quick release of insulin into the bloodstream, and that the nano-networks contain enough insulin to regulate blood glucose levels for up to 10 days."

"When the insulin runs out, you have to inject a new nano-network," says Jin Di, lead author of the paper and a Ph.D. student in Gu's research lab. "The previous nano-network is dissolved and fully absorbed into the body in a few weeks."

"This advance will certainly give millions of people with diabetes worldwide hope that better days are ahead," says Dr. John Buse, director of UNC-Chapel Hill's Diabetes Care Center and deputy director of UNC-Chapel Hill's NIH Clinical and Translational Sciences Award. "We must work to translate these exciting studies in the lab to clinical practice."


'/>"/>

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

Related biology news :

1. Nanoparticles can overcome drug resistance in breast cancer cells
2. Making complex nanoparticles easily reproducible
3. Gold nanoparticles give an edge in recycling CO2
4. Stealth nanoparticles lower drug-resistant tumors defenses
5. Researchers figure out why gold nanoparticles can penetrate cell walls
6. Nanoparticles, pH phoresis could improve cancer drug delivery
7. MU researchers develop radioactive nanoparticles that target cancer cells
8. Trackable drug-filled nanoparticles -- a potential weapon against cancer
9. X-rays reveal uptake of nanoparticles by soya bean crops
10. Achilles heel: Popular drug-carrying nanoparticles get trapped in bloodstream
11. Nanoparticles reach new peaks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ultrasound, nanoparticles may help diabetics avoid the needle
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
Breaking Biology Technology: