Navigation Links
Ultrasensitive imaging method uses gold-silver 'nanocages'
Date:4/12/2010

rnal Angewandte Chemie's international edition. The paper was written by Purdue chemistry doctoral student Ling Tong, Washington University graduate student Claire M. Cobley and research assistant professor Jingyi Chen, Xia and Cheng.

The new imaging approach uses a phenomenon called "three-photon luminescence," which provides higher contrast and brighter images than conventional fluorescence imaging methods. Normally, three-photon luminescence is too dim to be used for imaging. However, the presence of gold and silver nanoparticles enhances the brightness, overcoming this obstacle. The ultrafast laser also is thought to possibly play a role by causing "third harmonic generation," which increases the brightness.

Previous research to develop the imaging system has required the use of "plasmons," or clouds of electrons moving in unison, to enhance brightness and contrast. However, using plasmons generates tissue-damaging heat. The new technique does not use plasmon enhancement, eliminating this heating, Cheng said.

The three-photon effect might enable scientists to develop advanced "non-linear optical techniques" that provide better contrast than conventional technologies.

"The three-photon imaging capability will potentially allow us to combine imaging and therapy for better diagnosis and monitoring," Xia said.

Researchers used a laser in the near-infrared range of the spectrum pulsing at the speed of femtoseconds, or quadrillionths of a second. The laser pulses 80 million times per second to illuminate tissues and organs after nanocages have been injected, Cheng said.

The cages and particles are about 40 nanometers wide, or roughly 100 times smaller than a red blood cell.

The researchers intravenously injected the nanocages into mice and then took images of the tiny structures in tissue samples from organs such as the liver and spleen.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers develop new ultrasensitive assay to detect most poisonous substance known
2. NJIT physicist sees terahertz imaging as ultimate defense against terrorism
3. Tissue engineering, imaging neuronal circuits featured in Cold Spring Harbor Protocols
4. The embryonic heart: Imaging life as it happens
5. Now in broadband: Acoustic imaging of the ocean
6. Cancer therapy using unique imaging, delivery system focus of NSF CAREER Award
7. SNM warns patients about imaging test delays due to worldwide Mo-99 shortage
8. Method of the future uses single-cell imaging to identify gene interactions
9. Imaging method for eye disease used to eye art forgeries
10. GE Healthcare to evaluate and develop novel imaging technology
11. Researchers demonstrate nanoscale X-ray imaging of bacterial cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ultrasensitive imaging method uses gold-silver 'nanocages'
(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
(Date:7/11/2014)... Researchers have pioneered a revolutionary new way ... called Virtual Finger, allows scientists to move through ... synapses using the flat surface of their computer ... studies orders of magnitude more efficient, saving time, ... many areas of experimental biology. The software and ...
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... Scientists have known for some time that throwing off ... In fact, workers whose sleep-wake cycles are disrupted by ... such as diabetes, obesity and cancer. Researchers at ... a possible molecular link between circadian rhythm disturbances and ...
... Aug. 1 by scientists at Cold Spring Harbor Laboratory ... Meier-Gorlin syndrome (MGS) with specific cellular dysfunctions that are ... of dwarfism, small brain size, and other manifestations of ... Although only 53 cases of Meier-Gorlin syndrome have been ...
... team of researchers, including scientists from Wits University, have substantially ... of modern culture, all thanks to the San people of ... from South Africa, France, Italy, Norway, the USA and Britain, ... journal, Proceedings of the National Academy of Sciences , ...
Cached Biology News:Scientists discover molecular link between circadian clock disturbances and inflammatory diseases 2Scientists discover molecular link between circadian clock disturbances and inflammatory diseases 3Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size 2Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size 3Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size 4Modern culture 44,000 years ago 2Modern culture 44,000 years ago 3
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... the journal PNAS (Proceedings of the National Academy ... and sleep deprivation have a significant effect on our ... the best time of day to test for diseases ... medicines effectively. , Researchers from the University of Surrey ... links between sleep deprivation, body clock disruption and metabolism, ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2Time of day crucial to accurately test for diseases, new research finds 2
... April 5, 2011 Embryo Donation International ... facilities in the United States, officially opened today to ... globe desiring to build a family.     ... mission is to reduce the number of frozen ...
... YORK, April 5, 2011 Reportlinker.com announces that ... its catalogue: DNA Sequencing - ... http://www.reportlinker.com/p0203540/DNA-Sequencing---technologiesmarkets-and-companies.html This report briefly ... sequencing technologies, and their applications. Current large and ...
... PITTSBURGH, April 5, 2011 Mylan Inc. (Nasdaq: ... subsidiary Bioniche Pharma has launched Octreotide Acetate Injection ... Novartis, Sandostatin®, a treatment for a rare hormonal ... used to suppress or inhibit severe diarrhea associated ...
Cached Biology Technology:A New Company Is Born - Embryo Donation International 2Reportlinker Adds DNA Sequencing - Technologies, Markets and Companies 2Mylan Launches Generic Version of Sandostatin® 2
Mouse monoclonal antibody raised against a partial recombinant PASK. NCBI Entrez Gene ID = PASK...
Agarose II (Low Melt)...
...
... I can be used in intracellular staining ... cells and to serve as an antibody ... cell permeabilization is a reversible process, it ... the presence of saponin during intracellular staining. ...
Biology Products: