Navigation Links
Ultrafine particles in air pollution may heighten allergic inflammation in asthma
Date:7/1/2010

A new academic study led by UCLA scientists has found that even brief exposure to ultrafine pollution particles near a Los Angeles freeway is potent enough to boost the allergic inflammation that exacerbates asthma.

Published online in the American Journal of PhysiologyLung Cellular and Molecular Physiology in June, the study shows that the tiniest air pollutant particles ― those measuring less than 180 nanometers, or about one-thousandth the width of a human hair ― incited inflammation deep in the lungs. The researchers used a "real-time" testing method in an animal model to isolate the effects of vehicular emission particles on the immune response in the lung.

Since these ultrafine particles are primarily derived from vehicular emissions and are found in highest concentrations on freeways, the results have particular significance for the study of the impact of traffic-related emissions on asthma flares in urban areas.

The findings also point to the importance of understanding the role air-pollution particles play in asthma flares in order to develop new approaches for asthma therapy.

"The immune processes involved in asthma, and current treatments, are traditionally thought to be dominated by a specific initial immune response, but our study shows that ultrafine pollution particles may play an important role in triggering additional pathways of inflammation that heighten the disease," said the study's principal investigator, Dr. Andre E. Nel, professor of medicine and chief of nanomedicine at the David Geffen School of Medicine at UCLA.

Pollution particles emitted by vehicles and other combustion sources are coated with a layer of organic chemicals that can be released into the lungs. These chemicals generate free oxygen radicals, which excite the immune system in the lung through a cell- and tissue-

damaging process known as oxidation. Oxidation contributes to allergic
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-0777
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
2. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
3. Worldwide atmospheric measurements will determine the role of atmospheric fine particles
4. MIT: Remote-control nanoparticles deliver drugs directly into tumors
5. MIT sculpts 3-D particles with light
6. Tiny dust particles from Asian deserts common over western United States
7. Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
8. Researchers mimic bacteria to produce magnetic nanoparticles
9. Environmental fate of nanoparticles depends on properties of water carrying them
10. Nanoparticles assemble by millions to encase oil drops
11. New ORNL process brings nanoparticles into focus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ultrafine particles in air pollution may heighten allergic inflammation in asthma
(Date:7/30/2014)... Portland Press Limited today announced an across-the-board increase ... , The 2013 InCites Journal Citation Reports (Thomson ... Biochemical Journal , Essays in Biochemistry ... Bioscience Reports all received increases in their ... Biochemical Society and published by Portland Press Limited. ...
(Date:7/30/2014)... decisions about what they eat, the Food and Drug ... the Nutrition Facts label found on nearly every food ... & Engineering News (C&EN), the weekly news magazine ... and the fight that has ensued. , Britt ... while the Nutrition Facts label has remained largely the ...
(Date:7/30/2014)... Brembs, professor of neurogenetics at the Institute of Zoology, ... readers and reviewers to run the underlying code within ... forward for scientific publishing, by demonstrating a completely novel ... , Figure 3 in fact doesn,t really exist. The ... F1000Research , and the figure is generated ,on the ...
Breaking Biology News(10 mins):Across-the-board Impact Factor increases for Portland Press Limited 2F1000Research brings static research figures to life 2
... coastal habitats may release as much as 1 billion tons ... higher than previously reported, according to a new Duke led ... , the analysis provides the most comprehensive estimate of global ... date: 0.15 to 1.2 billion tons. It suggests there is ...
... September 6, 2012The naturally occurring cytokine interleukin-18, or IL-18, ... implicated in serious inflammatory diseases for which the prognosis ... Therapies targeting IL-18 could prove effective against inflammatory diseases ... pulmonary disease (COPD), as described in a review article ...
... release is available in Spanish . ... (ICCAT) is to invest 1.5 million euros in two research ... 2012 by AZTI-Tecnalia, the technological centre specialised in marine and ... the first project, the consortium co-ordinated by AZTI-Tecnalia will capture, ...
Cached Biology News:Destroyed coastal habitats produce significant greenhouse gas 2Promising new drug target for inflammatory lung diseases 2AZTI-Tecnalia leads 2 research projects on bluefin tuna with 1.5 million euros investment 2
(Date:7/31/2014)... 31, 2014 “Rapid technological advances ... the U.S., increasing unemployment, depressing American consumer spending ... is a Catch 22—we need automated manufacturing if ... fewer jobs,” says economist and corporate relocation expert ... Top 10 Pro-Business States for 2014, co-published with ...
(Date:7/31/2014)... Sales Horizons, a leader in sales training, today ... – Mastering the Complex Sale – to ... proven sales training programs used by thousands of salespeople ... sales training course is available to every salesperson as ... customers, like technical support, engineers, clinical support, and IT ...
(Date:7/30/2014)... 30, 2014 A study presented at ... and efficacy of CSL Behring,s C1 Inhibitor (C1-INH) ... in highly sensitized patients. C1-INH is a human ... system. The study shows that post-transplant ... the levels of complement components 3 and 4, ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Sales Horizons, ... launch of blended sales training programs for companies engaged ... training programs used by thousands of salespeople over 25 ... sales training program can be customized to address the ... The blended sales training program consists of ...
Breaking Biology Technology:ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 2Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 3
... 20 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, ... has been granted,U.S. Patent 7,374,752 entitled "Reovirus ... claims cover pharmaceutical compositions,which comprise various recombinant ... with additional patent protection for,reovirus compositions in ...
... ... Annual Meeting, ... with asthma not adequately controlled on the inhaled,corticosteroid fluticasone propionate ... the equivalent dose of,FP combined with salmeterol administered as Advair ...
... Kosan Biosciences,Incorporated (Nasdaq: KOSN ) today ... Senior Vice President and Chief Medical Officer. Dr. ... and registration of cancer,therapeutics and has had a ... clinical pharmacologist, most notably at Novartis. Dr. Cohen,joins ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces Issuance of 27th U.S. Patent 2Asthma Patients Not Adequately Controlled on ICS Alone More Likely to Benefit From Advair(R) Than Doubling the Dose of ICS 2Asthma Patients Not Adequately Controlled on ICS Alone More Likely to Benefit From Advair(R) Than Doubling the Dose of ICS 3Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer 2Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer 3Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer 4
... Serum is obtained from ... from healthy, fasted donors. The ... any way and are maintained ... Total Protein Concentration : ...
Hamster serum...
... Captiva 96-well Filter Plates are offered in ... 0.45 um depth filter plates are ideal ... analysis. Filtration is simple, versatile, and necessary ... The Captiva 10 um glass fiber and ...
... cDNA Labeling Kit with CyScribe GFX ... generation and purification of Cy3- and ... for complete cDNA labeling and purification.Flexible ... for performing labeling reactions with either ...
Biology Products: