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Ulcer bacteria may contribute to development of Parkinson's disease
Date:5/22/2011

ting that normal aging increases susceptibility to Parkinsonian changes in mice, as is seen in humans," says Testerman.

In order to determine whether the modified cholesterol or other substances could be responsible for Parkinson's disease development, they fed aged mice with H. pylori extracts. The mice did not become infected but developed the same symptoms as those infected with the bacteria, suggesting that the modified cholesterol or some other product contained within the bacteria contribute to disease development.

"Our mouse model demonstrates a direct effect of H. pylori infection on the development of Parkinson's disease. The observation that not all H. pylori strains are equally able to cause symptoms will allow us to investigate bacterial factors and/or immune response to H. pylori infection that increase the risk for Parkinson's disease," says Testerman.


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Contact: Jim Sliwa
jsliwa@asmusa.org
American Society for Microbiology
Source:Eurekalert

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