Navigation Links
Ulcer bacteria may contribute to development of Parkinson's disease
Date:5/22/2011

NEW ORLEANS, LA May 22, 2011 -- The stomach bacteria responsible for ulcers could also play a role in the development of Parkinson's disease according to research presented today at the 111th General Meeting of the American Society for Microbiology.

"Infection of late middle-aged mice with a particular strain of the bacteria Helicobacter pylori results in development of Parkinson's disease symptoms after 3-5 months," says Traci Testerman of Louisiana State University Health Sciences Center, Shreveport, who presented the research. "Our findings suggest that H. pylori infection could play a signficant role in the development of Parkinson's disease in humans."

Physicians have noted a correlation between stomach ulcers and Parkinson's disease as far back as the 1960s, before it was even known that H. pylori was the cause of ulcers. More recently, a number of studies found that people with Parkinson's disease were more likely to be infected with the bacterium, and that Parkinson's patients who were treated and cured of infection showed slight improvement compared to controls that continued to deteriorate.

In Guam, a study of why some populations had a high risk of developing a Parkinson's-like disease discovered that a specific compound in cycad seeds eaten by these populations was neurotoxic. The compound, which resembles a cholesterol with an attached sugar group, is almost identical to a compound produced by H. pylori.

Testerman and her colleagues developed an animal model to more effectively understand the role of H. pylori and its modified cholesterol in Parkinson's disease. They infected young and aged mice with three different strains of the bacteria and monitored their locomotor activity and dopamine levels in the brain. Mice infected with one of the strains showed significant reductions in both.

"The results were far more dramatic in aged mice than in young mice, demonstrating that normal aging increases susceptibility to Parkinsonian changes in mice, as is seen in humans," says Testerman.

In order to determine whether the modified cholesterol or other substances could be responsible for Parkinson's disease development, they fed aged mice with H. pylori extracts. The mice did not become infected but developed the same symptoms as those infected with the bacteria, suggesting that the modified cholesterol or some other product contained within the bacteria contribute to disease development.

"Our mouse model demonstrates a direct effect of H. pylori infection on the development of Parkinson's disease. The observation that not all H. pylori strains are equally able to cause symptoms will allow us to investigate bacterial factors and/or immune response to H. pylori infection that increase the risk for Parkinson's disease," says Testerman.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Stomach ulcer bug causes bad breath
2. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
3. Glutamine supplements show promise in treating stomach ulcers
4. Uncovering the secrets of ulcer-causing bacteria
5. Taking sharper aim at stomach ulcer bacteria
6. Oxidized form of a common vitamin may bring relief for ulcerative colitis
7. Olive oil could guard against developing ulcerative colitis
8. WHO guidelines on Buruli ulcer need adjustment
9. Probiotic identified to treat ulcers
10. Disinfectants can make bacteria resistant to treatment
11. H. Pylori bacteria may help prevent some esophageal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... ... and services based in Aurora, Ohio, has broken ground on a new building ... Research Triangle Park area, this new location solidifies a commitment to business in ...
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, ... veterinary clients have treated over 100 of their own patients with the VetStem Cell ... highest level of care for their patients. , The veterinarians are Dr Ross ...
(Date:5/20/2016)... ... ... The recent recall by Costco and Trader Joes of 47 million pounds ... 2016(1), demonstrates the need for faster and more cost effective bio-threat detection to ensure ... , PathSensor’s latest solution uses a biosensor technology called CANARY®. CANARY®, ...
(Date:5/19/2016)... 19, 2016 There is no ... given the relentless pressures in pricing and lack in ... investors circle though - numerous opportunities are up for ... session, ActiveWallSt.com,s presents four names in this sector: Portola ... Inc. (NASDAQ: VTAE ), Anthera Pharmaceuticals Inc. ...
Breaking Biology Technology: