Navigation Links
UWM researcher predicts stem cell fate with software
Date:2/16/2010

e says, "and that could potentially make the patient's vision worse."

Finding a solution has been hampered by the fact that there are very few markers that can predict cell division outcomes.

Subtle behaviors that characterize populations of stem cells with different fates are difficult or impossible for human observers to recognize. Cohen's tool, which runs on a standard PC, is able to track and generate predictions for up to 40 cells in real time. It outperforms the human eye in detecting differences in how the cells change over time.

Current methods of observing live cells produce terabytes of data, a volume that requires massive amounts of computation to find the most relevant information. A new computer cluster in CEAS was acquired for just this kind of research. To manage the predictive aspects of the program, Cohen used a uniquely sensitive mathematical approach based on algorithmic information theory.

Answers in DNA

Scientists know little about programming of stem cell outcomes except that it is a multifaceted process.

"In many cases, stem cells take their developmental cues from their environment," says Cohen. "Part of the programming mechanism is determined by surrounding cells. But once these cells begin to develop in a particular way, their offspring continue down that path even if the environment changes. So at some point they have been programmed to their fate."

The researchers designed the software to be used for isolating the genes and proteins that control the specialization process, which could allow researchers to identify and ultimately manipulate these programmed mechanisms.

Brian Link is a developmental biologist at the Medical College of Wisconsin who works with Cohen but is not an author on the Nature Methods paper. The two will be putting the software to the test to study behaviors of organelles within the cell as indicators of stem cell fate.

"The metho
'/>"/>

Contact: Andrew Cohen
cohena@uwm.edu
414-229-5861
University of Wisconsin - Milwaukee
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers identify mechanism for Frank-Ter Haar syndrome
2. OHSU researchers discover cellular mechanism that protects against disease
3. Cameras of the future: heart researchers create revolutionary photographic technique
4. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
5. Caltech researchers obtain first brain recordings from behaving fruit flies
6. Researchers envision high-tech applications for multiferroic crystals
7. Dartmouth researchers describe how the cholera bacteria becomes infectious
8. Researchers develop dietary formula that maintains youthful function into old age
9. Queens researchers propose rethinking renewable energy strategy
10. MDC researchers develop new tool to investigate ion channels
11. New era of pain drugs advanced by Barrow researcher
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UWM researcher predicts stem cell fate with software
(Date:9/19/2014)... Durante of dinosaurs a newly discovered hadrosaur ... dinosaur, named Rhinorex condrupus by paleontologists ... University, lived in what is now Utah approximately ... period. , Rhinorex, which translates roughly into "King ... of other Cretaceous hadrosaurs like Parasaurolophus and Edmontosaurus. ...
(Date:9/19/2014)... researchers from several Harvard University labs in collaboration ... aspiring researchers with the intellectual raw materials needed ... soft, flexible materials. , With the advent of ... in manufacturing technology, soft robotics is emerging as ... conventional rigid robot design, but working with pliable ...
(Date:9/19/2014)... the unique bioelectric signaling system of the electric fish, ... The OU researcher is working to understand how these ... used to map the world around them. Electric ... discharges a second throughout their lives. The energetic ... necessary for survival. , "There is evidence that electric ...
Breaking Biology News(10 mins):New hadrosaur noses into spotlight 2Soft robotics 'toolkit' features everything a robot-maker needs 2
... Company Anticipates Acquisition Could More Than Double its Current ... the Medical and Healthcare Industry, SAN JOSE, Calif., ... a leading biometric and security,solutions provider, announced today the ... Medical Systems (OTC: CHSY), a company listed in,the US ...
... The gigantic fossil claw of an 390 million-year-old sea scorpion, ... insects, crabs and the like were surprisingly larger than ... O. Erik Tetlie , postdoctoral associate in the Department of ... of the report online in Royal Society Biology Letters. The ...
... Newly launched nerve cells in a growing embryo must chart ... use to navigate have yet to surface. In a study published ... Salk Institute for Biological Studies have recovered a key signal that ... spinal cord and must find their way down the length of ...
Cached Biology News:Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network 2Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network 3Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network 4Salk scientists identify key nerve navigation pathway 2Salk scientists identify key nerve navigation pathway 3
(Date:9/20/2014)... (PRWEB) September 20, 2014 Entries are ... Prism Awards for Photonics Innovation . The international ... multi-billion dollar optics and photonics industry, and is sponsored ... photonics , and Photonics Media . , The ... versatility of photonics, said SPIE CEO Eugene Arthurs. , ...
(Date:9/20/2014)... HealthTronics, Inc. , a ... products and services, has signed a distribution agreement ... Corporation for its high precision laser technology. ... invasive, mobile, surgical technology—offering more choices for healthcare ... HealthTronics will make available Clinicon’s FDA-cleared SureLase™ CO2 ...
(Date:9/20/2014)... September 20, 2014 MediVet America ... perform a groundbreaking surgery at the specialized Wolvega Horse ... superficial digital flexor tendon was ruptured 90% and her ... injury is a death sentence for a horse. , ... stem cell treatments . This revolutionary regenerative option ...
(Date:9/19/2014)... Sept. 19, 2014  InterMune, Inc. (Nasdaq: ... Memorandum of Understanding to settle the litigation in the ... Plan of Merger dated as of August 22, 2014, ... Inc.  As one term of the Memorandum of Understanding, ... forth in the attached exhibit reflecting the amendment to ...
Breaking Biology Technology:Entry deadline is 10 October for international photonics Prism Awards 2Entry deadline is 10 October for international photonics Prism Awards 3Entry deadline is 10 October for international photonics Prism Awards 4HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19
... 25 Scimitar Equity, LLC issues a ... VOQP), entitled,"Creating Value; Turnaround Leverages Product Opportunities ... review is available at website: http://www.scimitarequity.com ... Jersey-based biotechnology company,dedicated to becoming a recognized ...
... 25 Mymetics,Corporation (OTC: MYMX), will be holding an ... PM New York Time to update all shareholders,on the ... Form 10-Q and to,address recent press articles., You ... at +1-866-591-4361 PIN 815,726 and from Europe at +41-800-329-326 ...
... 23 Eisai Corporation of,North America and its ... Food and Drug Administration (FDA) has approved a ... prevention of,chemotherapy-induced nausea and vomiting (CINV). ALOXI Capsules ... prevention of acute nausea and,vomiting following initial and ...
Cached Biology Technology:VioQuest Pharmaceuticals, Inc Q2/08 Review Issued by Scimitar Equity, LLC 2FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 2FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 3