Navigation Links
UWM researcher predicts stem cell fate with software

A software program created by an engineer at the University of WisconsinMilwaukee (UWM) can not only predict the types of specialized cells a stem cell will produce, but also foresee the outcome before the stem cell even divides.

The software, developed by Andrew Cohen, an assistant professor of electrical engineering, analyzes time-lapse images capturing live stem cell behaviors. It will allow scientists to search for mechanisms that control stem cell specialization, the main obstacle in advancing the use of stem cell therapy for treatment of disease. It could also lead to new research into causes of cancer, which involves cells that continuously self-renew.

Stem cells play a key role in human development, and also offer the potential to repair tissues or organs damaged by disease or injury. But, in order to use stem cell-based therapies, biologists need to better understand the mechanisms that control stem cell differentiation.

"This is a brand-new set of tools for developmental biologists," says Cohen, "and it supports an area where no other predictive solutions exist."

The research is published Feb. 7 in the journal Nature Methods. Co-authors are Michel Cayouette and Francisco Gomez neurobiologists at the Institut de recherches cliniques de Montreal, and Badri Roysam, a computer engineering professor at Rensselaer Polytechnic Institute.

The software is 87 percent accurate in determining the specific "offspring" a stem cell will ultimately produce, and 99 percent accurate in predicting when self-renewal of these stem cells will end in specialization.

A hunt for markers

As an example of the software's utility, Cohen cites using stem cells to treat the eye disease macular degeneration. The stem cells would need to produce more photoreceptor neurons for treatment to succeed. "But if you simply implant the stem cells into the retina, there are other types of cells that could develop," h

Contact: Andrew Cohen
University of Wisconsin - Milwaukee

Page: 1 2 3

Related biology news :

1. Researchers identify mechanism for Frank-Ter Haar syndrome
2. OHSU researchers discover cellular mechanism that protects against disease
3. Cameras of the future: heart researchers create revolutionary photographic technique
4. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
5. Caltech researchers obtain first brain recordings from behaving fruit flies
6. Researchers envision high-tech applications for multiferroic crystals
7. Dartmouth researchers describe how the cholera bacteria becomes infectious
8. Researchers develop dietary formula that maintains youthful function into old age
9. Queens researchers propose rethinking renewable energy strategy
10. MDC researchers develop new tool to investigate ion channels
11. New era of pain drugs advanced by Barrow researcher
Post Your Comments:
Related Image:
UWM researcher predicts stem cell fate with software
(Date:9/30/2015)... global glucose monitoring device and diabetes management market is valued ... on the industry from Kalorama Information. Sales in the traditional glucose ... continuous glucose monitoring and sensor segment, according to the healthcare ... in its latest report, The Global Glucose Monitoring Market ... , ...
(Date:9/28/2015)... , Sept. 28, 2015  The monitoring of ... and body temperature, is an essential component of ... indicators of deterioration in a patient,s condition. However, ... signs are typically taken during routine observation rounds ... a patient deteriorates between these observation rounds, the ...
(Date:9/26/2015)... MONTREAL , Sept. 26th, 2015  Results ... home will be unveiled today at the Stanford ... Patient Engagement Using iPad Dashboards, Connected Health Devices ... Founder of Pharmacy 3.0, will explain how senior ... over data to their pharmacist via the TactioRPM ...
Breaking Biology News(10 mins):
... Scientists believe that prior to the advent of ... life used RNA to encode genetic instructions. What sort ... The answer may be AEG, a small molecule when ... Acids, which have been hypothesized as the first genetic,molecules. ...
... Can you imagine trying to build a competitive race ... fare well at the Indy 500. Very much the same ... Texas A&M AgriLife Research scientist. "Contemporary crops such as ... need high quality parts to perform optimally," said Dr. David ...
... substances, such as earth -- and amylophagy, eating raw starches ... U.S. Some 180 species of animals are also known to ... A study appearing Oct. 17 in the online journal Public ... pica in Madagascar. It is one of only a few ...
Cached Biology News:
(Date:10/8/2015)... 2015  Sorrento Therapeutics, Inc. (NASDAQ:  SRNE; Sorrento), ... cancer and associated pain, announced today that Dr. Henry Ji, ... at the Aegis Capital Corporation 2015 Growth Conference ... Corporation 2015 Growth ConferenceDate:Friday, October 9, 2015Time:10:00 to ... The Wynn in Las Vegas, NV , ...
(Date:10/8/2015)... 8, 2015 Celemics, a global pioneer of ... North American market with the establishment of Celemics America, ... Europe , has secured itself in ... methodology and sample preparation for DNA sequencing and genetic ... and somatic genetic testing more accurately, quickly, and cost ...
(Date:10/8/2015)... Del. , Oct. 8, 2015  Today, ... CRISPR-Cas technologies for genome editing, jointly announced a ... and Caribou have cross-licensed their respective patent portfolios, with ... technology applications in major row crops, and non-exclusive ... --> --> ...
(Date:10/8/2015)... 2015  Sigma-Aldrich Corporation (NASDAQ: SIAL ) ... within its Applied Diagnostics and Testing business segment ... product line with ten certified Snap-N-Spike ® ... and their stable-labeled internal standards. These new solution ... taurocholic acid and native and deuterium-labeled analogs of ...
Breaking Biology Technology:
... , Sylviane Komesli, Martine Page, and ... Laboratoires Fournier S.A., France , ... and type II receptors form ligand dependent heteromeric signaling complexes, in which ... primary receptor. In the present study, we investigated the feasibility of using ...
... , ... radiometric screening assays. The Wallac MicroBeta effectively measures both plate types. , ... one above the sample and one below. , ... are conducted with the upper PM tube only. A comparison is made ...
... Heidi Grecsek , ... 710 Bridgeport Avenue , ... , The Clean Air Act amendments of 1990 ... content. Oxygenated fuel is desirable because it burns more completely, thereby reducing tailpipe emissions. ...
Cached Biology Technology:
Request Info...
Bovine Serum Albumin Heat Shock Diagnostic Grade Powder...
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
MpV17 transgene, murine homolog, glomerulosclerosis...
Biology Products: