Navigation Links
UW-Madison scientists create super-strong collagen
Date:1/12/2010

MADISON A team of University of Wisconsin-Madison researchers has created the strongest form of collagen known to science, a stable alternative to human collagen that could one day be used to treat arthritis and other conditions that result from collagen defects.

"It's by far the most stable collagen ever made," says Ron Raines, a University of Wisconsin-Madison professor of chemistry and biochemistry who led the study, published in the Jan. 12 issue of the Proceedings of the National Academy of Sciences.

Collagen is the most abundant protein in the human body, forming strong sheets and cables that support the structure of skin, internal organs, cartilage and bones, as well as all the connective tissue in between. For decades, doctors have used collagen from cows to treat serious burns and other wounds in humans despite the risk of tissue rejection associated with cross-species transplants.

In 2006, Raines' team figured out how to make human collagen in the lab, creating collagen molecules longer than any found in nature. Now, with funding from the National Institutes of Health, the researchers have taken this line of inquiry one step further, creating a form of super-strong collagen that may one day help millions. Raines says this artificial collagen holds promise as a therapy for conditions such as arthritis, which is caused by a breakdown of the body's natural collagen and affects more than 46 million Americans.

To make the new form of collagen, Raines' team substituted two-thirds of the protein's regular amino acids with less-flexible versions that stiffened the overall structure of the protein and helped it hold its form. "The breakthrough of this approach was the use of rigid analogues that have shapes similar to [the shapes the natural amino acids take] in the folded, functional form of the protein," explains Raines.

The resulting collagen holds together at temperatures far above what it takes for natural collagen to fall apart. And although it's built largely from amino acids that aren't found in nature, X-ray crystallography confirms that the three-dimensional structure of the lab-made collagen is indistinguishable from that of natural collagen, according to UW-Madison bacteriologist Katrina Forest, a co-author of the study.

"This hyper-stable collagen is really a testament to the power of modern protein chemistry," says Raines.


'/>"/>

Contact: Ron Raines
rtraines@wisc.edu
626-395-3076
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. ESA to feature wide range of UW-Madison presentations
2. UW-Madison study reveals new options for people with PKU
3. Sweet corn story begins in UW-Madison lab
4. UK scientists working to help cut ID theft
5. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
6. Comet probes reveal evidence of origin of life, scientists claim
7. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
8. Male elephants get photo IDs from scientists
9. Scientists retrace evolution with first atomic structure of an ancient protein
10. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
11. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... , March 11, 2016 ... new market research report "Image Recognition Market by Technology ... (Marketing and Advertising), by Deployment Type (On-Premises and Cloud), ... To 2022", published by MarketsandMarkets, the global market is ... to USD 29.98 Billion by 2020, at a CAGR ...
(Date:3/10/2016)... 2016   Unisys Corporation (NYSE: UIS ) ... (CBP) is testing its biometric identity solution at the Otay ... to help identify certain non-U.S. citizens leaving the country. ... to help determine the efficiency and accuracy of using biometric ... will run until May 2016. --> the ...
(Date:3/9/2016)... HAMBURG, Germany , March 9, 2016 ... African country,s government identified that more than 23,000 public ... name or had been receiving their salary unlawfully.    ... West African country,s government identified that more than 23,000 ... recorded name or had been receiving their salary unlawfully. ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... At present, the Biotech sphere is in a ... volatility is what makes this industry interesting to consider. Here ... (NASDAQ: SNTA ), CTI BioPharma Corp. (NASDAQ: ... and Heat Biologics Inc. (NASDAQ: HTBX ). Sign ... these stocks at: http://www.activewallst.com/register/ ...
(Date:5/26/2016)... , May 26, 2016 Despite ... see value in this space. Today,s pre-market research on ActiveWallSt.com ... Radius Health Inc. (NASDAQ: RDUS ), Cerus Corp. ... ARWR ), and Five Prime Therapeutics Inc. (NASDAQ: ... technical briefings at: http://www.activewallst.com/ ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a rising hotspot for ... one of its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm ... and intimate team-building experience. , Each event kicks off with an olive oil and ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... for information (RFI) issued by the Office of the National Coordinator for Health ... experience, and determines if clinically relevant data were available when and where it ...
Breaking Biology Technology: