Navigation Links
UVA researchers explain cell response to skin-damaging UV rays
Date:10/1/2007

CHARLOTTESVILLE, Va., Oct. 1, 2007 -- Its well known that overexposure to ultraviolet rays from the sun can cause major skin problems, ranging from skin cancer to sunburns and premature wrinkles. A tan, for example, is natures own UV protection and an unhealthy sign that your skin is damaged.

But what is not so well known is exactly how UV rays specifically interact with your DNA and the complex organelles and proteins found inside every cell of your body.

Researchers at the University of Virginia Health System have published a new study that helps scientists around the world expand the body of knowledge on how cells protect themselves (or not) from DNA damage caused by UV rays.

Their study reveals part of a simple switch mechanism inside cells, triggered by UV exposure from the sun, that helps our cells survive and thrive after being exposed. This mechanism involves an unanticipated connection between several proteins in the cell, the researchers discovered.

Their findings, published in the September 7th online issue of the journal Cell, describe part of a pathway inside human cells that regulates when and how cells repair damage to their DNA when irradiated with UV rays. The research was conducted by Ian Macara, PhD, professor of microbiology at UVas Center for Cell Signaling, along with two MD/PhD students at UVa, Brandon Kremer and Laura Adang.

When cells get DNA damage, normally they stop moving and stop responding to stimuli until they are repaired, Macara explains. We detail in this paper how a certain protein, called SOCS7, moves from the cytoplasm into the cell nucleus and essentially instructs the cell to stop dividing via a protein called NCK. The role of SOCS7 is both to stop outside signals from being relayed to the cell and to switch on the cells response to radiation damage. Cancer can arise if the repair work is not performed properly.

The SOCS7 protein is known to be involved in the bodys insulin response to blood glucose levels, but Macara said he was surprised to find SOCS7 involved in the response to cellular DNA damage as well. Macara said it will now be important to study whether the absence of SOCS7 in cells would make a person more susceptible to skin cancer.


'/>"/>

Contact: Megan Rowe
mbr4p@virginia.edu
434-924-5679
University of Virginia Health System
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)...  The American College of Medical Genetics and Genomics was ... as one of the fastest-growing trade shows during the Fastest ... in Las Vegas . ... in each of the following categories: net square feet of ... attendees. The 2015 ACMG Annual Meeting was ranked 23 out ...
(Date:6/22/2016)... WASHINGTON , June 22, 2016 On ... highly-anticipated call to industry to share solutions for the ... by U.S. Customs and Border Protection (CBP), explains that ... nationals are departing the United States ... criminals, and to defeat imposters. Logo - ...
(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
Breaking Biology Technology: