Navigation Links
UVA researchers explain cell response to skin-damaging UV rays
Date:10/1/2007

CHARLOTTESVILLE, Va., Oct. 1, 2007 -- Its well known that overexposure to ultraviolet rays from the sun can cause major skin problems, ranging from skin cancer to sunburns and premature wrinkles. A tan, for example, is natures own UV protection and an unhealthy sign that your skin is damaged.

But what is not so well known is exactly how UV rays specifically interact with your DNA and the complex organelles and proteins found inside every cell of your body.

Researchers at the University of Virginia Health System have published a new study that helps scientists around the world expand the body of knowledge on how cells protect themselves (or not) from DNA damage caused by UV rays.

Their study reveals part of a simple switch mechanism inside cells, triggered by UV exposure from the sun, that helps our cells survive and thrive after being exposed. This mechanism involves an unanticipated connection between several proteins in the cell, the researchers discovered.

Their findings, published in the September 7th online issue of the journal Cell, describe part of a pathway inside human cells that regulates when and how cells repair damage to their DNA when irradiated with UV rays. The research was conducted by Ian Macara, PhD, professor of microbiology at UVas Center for Cell Signaling, along with two MD/PhD students at UVa, Brandon Kremer and Laura Adang.

When cells get DNA damage, normally they stop moving and stop responding to stimuli until they are repaired, Macara explains. We detail in this paper how a certain protein, called SOCS7, moves from the cytoplasm into the cell nucleus and essentially instructs the cell to stop dividing via a protein called NCK. The role of SOCS7 is both to stop outside signals from being relayed to the cell and to switch on the cells response to radiation damage. Cancer can arise if the repair work is not performed properly.

The SOCS7 protein is known to be involved in the
'/>"/>

Contact: Megan Rowe
mbr4p@virginia.edu
434-924-5679
University of Virginia Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... A unique method for delivering compounds that ... HIV and AIDS may be possible, thanks ... Agricultural Sciences., A semi-soft vaginal suppository made ... loaded with the antiviral drug Tenofovir provides ... against the spread of sexually transmitted infections ...
(Date:8/28/2014)... new roads will be built worldwide by 2050. Many ... where they bring an influx of destructive loggers, hunters ... has created a ,global roadmap, for prioritising road building ... demands of development and environmental protection. , The map ... natural importance of ecosystems and a ,road-benefits, layer that ...
(Date:8/28/2014)... more action is needed to ensure safeguards are in ... in PLOS ONE , researchers from Monash University, ... - combining results from different studies - to look ... areas, to determine whether they actually protect biodiversity. ... protecting an area from human exploitation made common sense, ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Protected areas proven to protect biodiversity 2
... 26 October 2008 Arpida (SWX: ARPN) today ... III clinical trials at the 48th Interscience Conference ... of America (IDSA) 46th annual meeting in Washington, ... antibiotic, showed high clinical cure rates which were ...
... 2008 -- The Soil Science Society of America (SSSA) recognized ... special Awards Ceremony during their Annual Meeting on Oct. 5-9 ... colleagues based on their professional achievements and meritorious service. Only ... be elected Fellow. The 2008 class of SSSA Fellows are: ...
... Berlin, Germany Current research suggests that stress may ... skin disease. The related report by Joachim et ... Cells towards Maturation and Migration: Key role of ICAM-1/LFA-1 ... American Journal of Pathology . Skin provides the ...
Cached Biology News:Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections 2Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections 3Soil Science Society of America presents 2008 fellows 2Soil Science Society of America presents 2008 fellows 3Soil Science Society of America presents 2008 fellows 4Soil Science Society of America presents 2008 fellows 5Stress may make you itch 2
(Date:8/29/2014)... August 29, 2014 Local veterinarian, Dr. ... Hospital are seeking candidates to participate in an investigational ... The ultimate goal of this study is to ... into one or two arthritically affected joints can help ... , Candidates for the current investigational study must be ...
(Date:8/29/2014)... 29, 2014 Intrinsic Imaging, an ... GAMP® 5 compliant imaging core lab, announced today ... II clinical trial to assess a new treatment ... trial, Intrinsic Imaging will provide comprehensive imaging core ... and charter development, site qualification, site training and ...
(Date:8/28/2014)... 2014 “This kit has an improved extraction ... 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin Product ... to plant owners and USDA-GIPSA inspection agencies that have a ... can take place in a matter of minutes with nothing ... test the feed and grain before accepting it, but they ...
(Date:8/28/2014)... PA (PRWEB) August 28, 2014 The ... create a culture that will allow individuals to perform ... becoming increasingly important for employers looking to compete in ... industries are embracing this trend, as the sector increasingly ... of a company, which will have real results on ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3
... Calif., Feb. 4 NeurogesX, Inc. (Nasdaq: ... commercializing novel pain management therapies, announced today that Anthony ... present at the 11th Annual BIO CEO & Investor ... 2009. Mr. DiTonno and Stephen Ghiglieri, Chief Financial Officer, ...
... Texcel,s custom medical device development and manufacturing ... the commercialization of their surgical, interventional, and implantable ... full array of services and technologies at the ... booth # 314.Texcel provides the manufacturing infrastructure and ...
... Art,s Way Manufacturing, Inc. (Nasdaq: ARTW ... Scientific, Inc. - Buildings For Science - has ... The new site, reflective of the company,s ... more user-friendly.Art,s Way Scientific ( http://www.buildingsforscience.com ) is ...
Cached Biology Technology:NeurogesX to Present at 11th Annual BIO CEO & Investor Conference 2NeurogesX to Present at 11th Annual BIO CEO & Investor Conference 3Texcel Highlights Medical Device Development & Manufacturing Solutions at MD&M West, booth 314 2Art's Way Manufacturing Announces Launch of New Web Site For Art's Way Scientific - Buildings For Science 2Art's Way Manufacturing Announces Launch of New Web Site For Art's Way Scientific - Buildings For Science 3
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Human/Mouse/Rat JNK Pan Specific Affinity Purified PAb...
D-biotin *50 mM aqueous solution* Secondary Detection Biotin–Avidin Detection Reagents Other...
Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1). [Source:Uniprot/SWISSPROT;Acc:P42892] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: