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UVA reports surprising findings related to myotonic muscular dystrophy
Date:12/17/2007

s are intermediary molecules that convey the genetic code in the DNA to the rest of the cell. RNAs are normally cut and pasted together by a process called RNA splicing. It is currently thought that the toxic RNA causes DM1 by disrupting normal RNA splicing.

Much of the research on DM1 is focused on factors that cause RNA splicing defects. Our work may provide explanations for pathogenic effects not accounted for by RNA mis-splicing, Mahadevan explained.

In this current study, Dr. Mahadevan and his colleagues built upon their groundbreaking research from 2006 which showed that toxic RNA causes DM1 and that getting rid of it actually reversed the disease process. Their latest findings demonstrate a new effect of RNA toxicity and how this may cause cardiac conduction abnormalities.


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Contact: Ellen McKenna
ecm6n@virginia.edu
434-982-4490
University of Virginia Health System
Source:Eurekalert

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