Navigation Links
UVA reports surprising findings related to myotonic muscular dystrophy
Date:12/17/2007

CHARLOTTESVILLE, VA (Dec. 17, 2007) New research from the University of Virginia Health System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does several surprising things. DM1 is the most common form of muscular dystrophy in adults and affects approximately 40,000 adults and children in the U.S.

The protein, NKX2-5, is a biomarker for heart stem cells. It is also very important for the normal development of the heart. Too little of it causes major cardiac problems including slow and irregular heartbeats, observes Dr. Mani Mahadevan, a human genetics researcher and Professor of Pathology at UVa who led the study.

The researchers were surprised to find that mice and individuals with DM1 actually overproduce NKX2-5, yet experience the same kind of heart problems associated with too little of it.

Excessive NKX2-5 may explain why as many as 60 to 70 percent of individuals with DM1 develop heart problems which cause their heartbeats to become slow and irregular, often necessitating the need for pacemakers. If these irregular heartbeats are not detected, sudden death can occur.

By using the mouse model of DM1 and mice genetically engineered to produce less NKX2-5, Dr. Mahadevan and his team showed that reducing the excessive levels of NKX2-5 seemed to protect the mice from the heart problems.

Researchers were also surprised to find NKX2-5 in the muscles of mice and individuals with DM1. Usually, NKX2-5 is found only in the heart of adults, Dr. Mahadevan notes. Its like the muscle is having some kind of identity crisis and starting to make proteins that shouldnt be there normally.

This discovery could prove beneficial, says Dr. Mahadevan, and lead to development of a simple diagnostic test to follow a patients response to potential therapies.

Myotonic muscular dystrophy is recognized as the first example of a disease caused by a toxic RNA. RNA
'/>"/>

Contact: Ellen McKenna
ecm6n@virginia.edu
434-982-4490
University of Virginia Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. BIO-key Reports Second Quarter 2007 Results
2. Communication Intelligence Corporation Reports Second Quarter 2007 Financial Results
3. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
4. BIO-key Reports Third Quarter 2007 Results
5. WHRC releases 4 key reports
6. Rong Li Lab reports protein interactions of MAP kinase signaling pathway
7. European Union forests expanding, absorbing carbon at surprisingly high rate: study
8. The surprising story of Charles Darwin and his homeopathic doctor
9. New prostate cancer research findings
10. K-State researchers findings on E. coli
11. Claims of sex-related differences in genetic association studies often not properly validated
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... available in Spanish . ... study published in the Journal of Cell Biology ... for proper cell division , At this very moment thousands ... the mechanism by which the body repairs damaged tissues and ... complex process known as "mitosis", during which the cell duplicates ...
(Date:9/16/2014)... BEACH GARDENS, Fla. , Sept. 16, 2014 ... of biometric identity management solutions, announced today the ... solution designed to authenticate the identity of an ... The Android-based Verifier Sentry rapidly reads credential ... credential holder,s ID by matching the biometric to ...
(Date:9/15/2014)... A published study indicates that lowland tapir populations may ... on hunting. Researchers from the Office National de ... Guiana and San Diego Zoo Global reviewed data retrieved ... the last four years and compared this data to ... were placed on hunting tapirs in French Guiana," said ...
Breaking Biology News(10 mins):Unraveling cell division 2Unraveling cell division 3Cross Match Launches New Identity Management Handheld Solution 2
... Water is the life-blood of agriculture; it is the ... of crops needed to feed the world. The ample supply ... between feast and famine. Many parts of the world, however, ... available for agriculture. The reasons can range from drought and ...
... 22, 2010)A joint panel of experts from the Society ... of America (IDSA) today released online new clinical practice ... adults. The guidelines, to be published in the ... , update recommendations regarding the epidemiology, diagnosis, treatment and ...
... they use them, may be far more different then previously ... , according to research funded by the Wellcome Trust. ... Neuroscience , researchers from the University of Glasgow and the ... ,doublesex, (dsx), which determines the shape and structure of the ...
Cached Biology News:More water for life 2More water for life 3New guidelines for diagnosing, managing and treating Clostridium difficile 2Sex on the brain: 'Doublesex' gene key to determining fruit fly gender 2Sex on the brain: 'Doublesex' gene key to determining fruit fly gender 3
(Date:9/16/2014)... , Sept. 16, 2014  Donald Fresne, President and ... of Stephan Vagner , PhD to its Scientific Advisory ... of Toulouse, France , performed research at ... , and at Inserm, the French institute of health and ... works both at the Curie Institute, Orsay, France ...
(Date:9/16/2014)... Oro Valley, Arizona (PRWEB) September 16, 2014 ... company that develops safe and effective products to ... through the use of a proprietary SPACEā„¢ Technology ... Executive Officer and President will present at the ... 18, 2014 at the Hyatt Regency Phoenix. ...
(Date:9/16/2014)... 2014 BCC Research reveals in ... CELLS , the global market for stem cells is ... with a five-year compound annual growth rate (CAGR) of ... Americas with growth projections of $2.2 billion in 2014 ... http://photos.prnewswire.com/prnh/20140805/700528) , Unlike other potential applications of ...
(Date:9/15/2014)... Cancer Immunotherapy Market : Immune ... is a new market research report announced by ... types of therapeutics that have become the major ... (which is often called "immuno-oncology") in recent years: ... immunotherapy. , The regular use of immunotherapy ...
Breaking Biology Technology:New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 2Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 4Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 5
... 15 As drastic cutbacks at major,pharmaceuticals ... drug teams. Social networks have entered the ... are being scrutinized for,ROI. Product recalls and ... on drug marketers. Yet new marketing opportunities ...
... 2006 07/06 ... % % ... 31.99 74.3 27.97 74.7 14 Other EU Countries (2) ... 1.40 3.3 1.27 3.3 10, SLIT ...
... Production of Cloned Animals for Food,is Irresponsible ... Well-being, WASHINGTON, Jan. 15 Farm ... in association with,the American Anti-Vivisection Society (AAVS), ... ending experiments on animals, denounce the Food,and ...
Cached Biology Technology:Beyond DTC: Pharma Industry Faces New Challenges, Competition, Strategies for Market Dominance 2STALLERGENES: 2007: A Further Year of Strong Growth: Up 16% 2Animal Protection Groups Condemn FDA's Endorsement of Animal Cloning 2Animal Protection Groups Condemn FDA's Endorsement of Animal Cloning 3Animal Protection Groups Condemn FDA's Endorsement of Animal Cloning 4
...
Bovine Coronary Artery Smooth Muscle Cells (BCASMC) (>500,000 cells)...
... NPY Y2 Receptor antiserum This NPY ... spinal level and is currently being characerized in ... rat and mouse and appears to work better ... in rat. For full characterizarion in dorsal root ...
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
Biology Products: