Navigation Links
UVA radiation damages DNA in human melanocyte skin cells and can lead to melanoma
Date:7/1/2010

A new study by researchers at NYU School of Medicine found that UVA radiation damages the DNA in human melanocyte cells, causing mutations that can lead to melanoma. Melanocytes, which contain a substance called melanin that darkens the skin to protect it from the ultraviolet rays of the sun, are more vulnerable to UVA radiation than normal skin cells because they are unable to repair themselves as efficiently.

"For the first time, UVA rays have been shown to cause significant damage to the DNA of human melanocyte skin cells," says Moon-shong Tang, PhD, professor of environmental medicine, pathology and medicine at NYU School of Medicine. "And because melanocytes have a reduced capacity to repair DNA damage from UVA radiation, they mutate more frequently, potentially leading to the development of melanoma."

In this study, researchers exposed lightly and darkly pigmented human melanocytes to UVA radiation and assessed DNA damage and the capacity of these cells to repair damaged DNA. DNA damage was detected in all melanocyte cells and these cells were unable to repair the damage. Normal skin cells were also exposed to UVA light but no damage to their DNA was observed.

"Identifying the underlying causes of melanoma allows researchers to develop new ways to assess a person's risk of melanoma, prevent the disease and aid in the design of more effective treatments," said Dr. Tang, who is also a member of the NYU Cancer Institute.

Sunlight in the form of UVA radiation causes oxygen in melanocytes to damage DNA. Thus, oxidative DNA damage adversely affects transcription and DNA replication in melanocytes. The authors concluded that UVA-induced oxidative DNA damage in melanocytes and the inherently reduced repair capacity in these cells are the two key factors that contribute to melanoma on the skin.

The authors also discovered the underlying mechanism to explain why melanoma can also develop in areas never exposed to sunlight: Because melanocytes generally have a limited capacity to repair any DNA damage, they have a higher mutation frequency rate and are more susceptible to the development of melanomaeven without the effects of the sun.

"Melanoma, the deadliest form of skin cancer, continues to increase at a rate of 3 percent a year," says Dr. Tang. "This research highlights the necessity of limiting UVA radiation by avoiding excessive sunlight, tanning and sunbeds."


'/>"/>

Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related biology news :

1. Ultraviolet radiation not culprit killing amphibians, research shows
2. Study raises new concerns about radiation and breast cancer
3. First trial of pemetrexed with radiation and chemo in lung cancer shows promising results
4. Tool allows precise targeting of radiotherapy for cancer radiation therapy
5. Smoking during radiation therapy for head and neck cancers linked to poorer outcomes
6. Age, gender can affect risk to radiation treatment
7. E-beam and X-ray irradiation technologies
8. Epigenetics could help researchers determine any risks associated with low-dose radiation
9. Duke awarded up to $43 million to develop test for dirty bomb/radiation exposure
10. Discovery makes brain tumor cells more responsive to radiation
11. Patients in Europe benefit from new radiation therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017 Vigilant ... company serving law enforcement agencies, announced today the appointment ... as director of public safety business development. ... law enforcement experience, including a focus on the aviation ... his most recent position, Mr. Sheridan served as the ...
(Date:3/9/2017)... , Australia , March 9, ... study data at the prestigious World Lung Imaging Workshop ... Andreas Fouras , was invited to deliver the ... pulmonary medicine. This globally recognised event brings together leaders ... share the latest developments in lung imaging. ...
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... March 27, 2017  The global market for ... according to a new report from Kalorama Information.  ... is performed to evaluate disease progression, monitor drug ... other reasons.  The healthcare market research firm,s report, ... provides an overview of the medical laboratory industry ...
(Date:3/27/2017)... , March 27, 2017  Trovagene, Inc. (NASDAQ: ... its Chief Executive Officer, Bill Welch , will ... 4, 2017 at 9:00 AM EDT at the Essex ...  Bill Welch, and Chief Scientific Officer, Mark Erlander ... investors during the conference.   The presentation will ...
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets has ... Research - Global Strategic Business Report" report to their offering. ... This report ... in US$ Million. Annual estimates and forecasts are provided for the ... primary and secondary research. The report profiles 25 ...
(Date:3/23/2017)... ... March 23, 2017 , ... AxioMed president, Jake Lubinski, describes ... characteristics when deformed, which is identical to how the human discs work to ... and return to its natural state along a hysteresis curve, exactly like a ...
Breaking Biology Technology: