Navigation Links
UVA radiation damages DNA in human melanocyte skin cells and can lead to melanoma
Date:7/1/2010

A new study by researchers at NYU School of Medicine found that UVA radiation damages the DNA in human melanocyte cells, causing mutations that can lead to melanoma. Melanocytes, which contain a substance called melanin that darkens the skin to protect it from the ultraviolet rays of the sun, are more vulnerable to UVA radiation than normal skin cells because they are unable to repair themselves as efficiently.

"For the first time, UVA rays have been shown to cause significant damage to the DNA of human melanocyte skin cells," says Moon-shong Tang, PhD, professor of environmental medicine, pathology and medicine at NYU School of Medicine. "And because melanocytes have a reduced capacity to repair DNA damage from UVA radiation, they mutate more frequently, potentially leading to the development of melanoma."

In this study, researchers exposed lightly and darkly pigmented human melanocytes to UVA radiation and assessed DNA damage and the capacity of these cells to repair damaged DNA. DNA damage was detected in all melanocyte cells and these cells were unable to repair the damage. Normal skin cells were also exposed to UVA light but no damage to their DNA was observed.

"Identifying the underlying causes of melanoma allows researchers to develop new ways to assess a person's risk of melanoma, prevent the disease and aid in the design of more effective treatments," said Dr. Tang, who is also a member of the NYU Cancer Institute.

Sunlight in the form of UVA radiation causes oxygen in melanocytes to damage DNA. Thus, oxidative DNA damage adversely affects transcription and DNA replication in melanocytes. The authors concluded that UVA-induced oxidative DNA damage in melanocytes and the inherently reduced repair capacity in these cells are the two key factors that contribute to melanoma on the skin.

The authors also discovered the underlying mechanism to explain why melanoma can also develop in areas never exposed to sunlight: Because melanocytes generally have a limited capacity to repair any DNA damage, they have a higher mutation frequency rate and are more susceptible to the development of melanomaeven without the effects of the sun.

"Melanoma, the deadliest form of skin cancer, continues to increase at a rate of 3 percent a year," says Dr. Tang. "This research highlights the necessity of limiting UVA radiation by avoiding excessive sunlight, tanning and sunbeds."


'/>"/>

Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related biology news :

1. Ultraviolet radiation not culprit killing amphibians, research shows
2. Study raises new concerns about radiation and breast cancer
3. First trial of pemetrexed with radiation and chemo in lung cancer shows promising results
4. Tool allows precise targeting of radiotherapy for cancer radiation therapy
5. Smoking during radiation therapy for head and neck cancers linked to poorer outcomes
6. Age, gender can affect risk to radiation treatment
7. E-beam and X-ray irradiation technologies
8. Epigenetics could help researchers determine any risks associated with low-dose radiation
9. Duke awarded up to $43 million to develop test for dirty bomb/radiation exposure
10. Discovery makes brain tumor cells more responsive to radiation
11. Patients in Europe benefit from new radiation therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... DIEGO , June 27, 2016  Sequenom, Inc. ... committed to enabling healthier lives through the development of ... Court of the United States ... courts that the claims of Sequenom,s U.S. Patent No. ... patent eligibility criteria established by the Supreme Court,s Mayo ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software as ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and video ... trial team. , Using the CONSULT module, patients and physicians can schedule a face ...
(Date:6/27/2016)... Hill, N.C. (PRWEB) , ... June 27, 2016 ... ... U.S. commercial operations for Amgen, will join the faculty of the University ... serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a ...
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
Breaking Biology Technology: