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UV light improving chances of fighting cancer
Date:10/29/2007

an be targeted to kill cancer tumours with much greater specificity giving fewer side effects.

These cloaked antibodies can be used alone, or in conjunction with the many antibodies already produced against a wide variety of cancers as bispecific complexes. These complexes are formed from two antibodies, one antibody binds to a tumour marker, the other with a T-cell. The T-cell binding end remains inactive until re-activated by light. This means when the bispecific antibody binds to healthy tissues away from light, it cannot activate T-cells, resulting in far fewer side effects.

Professor Self says, This opens up so many possible applications for example, for patients who are undergoing surgery for prostate cancer. After the surgeon has removed the bulk of a tumour, the patient could then be injected with bispecific antibodies and a light shone at the affected area which would target the patients own immune system to the tumour site.

This is therefore a very specific treatment and while our work indicates that sunlight doesnt activate these antibodies, patients may have to be advised to avoid direct sunlight for a short period after treatment.


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Contact: Karen Bidewell
press.office@ncl.ac.uk
01-912-226-972
Newcastle University
Source:Eurekalert

Page: 1 2

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