Navigation Links
UTSA infectious disease researchers advancing vaccine against Valley fever
Date:7/7/2009

San Antonio Medical mycologists in The South Texas Center for Emerging Infectious Diseases (STCEID) and the Department of Biology at The University of Texas at San Antonio (UTSA) have significantly advanced the fight against San Joaquin Valley Fever, a respiratory infection of humans, commonly called Valley Fever, which is caused by the Coccidioides fungus. For the first time, the researchers have genetically engineered a live, attenuated vaccine that successfully protects mice against Valley Fever, known in scientific circles as coccidioidomycosis.

A live, attenuated vaccine is used as a preventative treatment based upon creation of a mutated form of the pathogen that is no longer capable of causing disease.

Coccidioides, a soil-dwelling fungus, is responsible for significantly increased numbers of respiratory infections among outdoor workers when compared to the general population. In addition, people with compromised T-cell immunity, the elderly and certain racial groups, such as African-Americans and Filipinos who live in the Southwestern United States, have an increased incidence of the infection's symptoms, caused by the inhalation of Coccidioides spores.

In approximately 40% of human Valley Fever cases, respiratory problems set in one to three weeks after inhalation. Although less than one percent of infected individuals experience severe symptoms, such as chronic-progressive pneumonia or meningitis, the incidence of reported primary pulmonary infection cases in Arizona and California is on the rise, having significantly increased in the last decade.

STCEID researchers at UTSA and Wilford Hall Medical Center at San Antonio's Lackland Air Force Base have long collaborated on Coccidioides studies in the hopes of developing a vaccine to better protect those who are exposed to it in the future. This most recent study has been funded by the National Institute of Allergy and Infectious Diseases, the California HealthCare Foundation and the Margaret Batts Tobin Foundation.

"Respiratory infections caused by Coccidioides tend to escape the radar of most large pharmaceutical companies, because only about 100,000 cases are reported each year," said Garry Cole, professor of biology at UTSA and the study's principal investigator.

He adds, "But when I look at 100,000 cases, I see 100,000 faces looking back at me."


'/>"/>

Contact: Christi Fish
christi.fish@utsa.edu
210-458-7584
University of Texas at San Antonio
Source:Eurekalert

Related biology news :

1. Northwestern to expose most deadly infectious diseases in 3-D
2. BWF awards $7 million to infectious disease investigators
3. ASM and FIND to partner on strengthening infectious disease diagnosis in developing nations
4. Scientists use remote satellite imaging to predict outbreaks of infectious disease
5. NSF, NIH award Ecology of Infectious Disease grants
6. World leaders in infectious diseases convene to discuss emerging global viruses
7. NIAID scientists to speak on range of infectious disease topics at major scientific meeting
8. The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
9. Team identifies a molecular switch linking infectious disease and depression
10. Ecologists question effects of climate change on infectious diseases
11. UCI awarded $45 million for infectious disease research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... --  EyeLock LLC , a market leader of iris-based ... IoT Center of Excellence in Austin, Texas ... embedded iris biometric applications. EyeLock,s iris authentication ... with unmatched biometric accuracy, making it the most proven ... platform uses video technology to deliver a fast and ...
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... operations for Amgen, will join the faculty of the University of North ... adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, ... launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, which ... to add Target to its list of well-respected retailers. This list includes such ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
Breaking Biology Technology: