Navigation Links
UTMB study discovers cause of many preterm births
Date:5/13/2014

A new study by researchers at the University of Texas Medical Branch at Galveston is the first to show that premature aging of the placenta due to oxidative stress is the cause of many preterm births. The study appears today in the American Journal of Pathology.

Researchers took fetal membranes, exposed them to oxidative stress in a lab setting (specifically cigarette smoke extract) and examined whether it caused rapid aging of the placental tissue. It did.

Oxidative stress factors include environmental toxins and pollution and are an inevitable component of normal living. However, other factors such as smoking and drinking, high body mass index, poor nutrition and infection could be avoided.

Antioxidants in the body control any damage caused by oxidative stress. But when oxidative stress becomes overwhelming, it can trigger premature placental aging, which can result in preterm birth.

According to the researchers, antioxidant supplements during pregnancy have failed to reduce preterm births because the mechanisms of oxidative stress damage are still unclear.

"This is the first study to look at and prove that oxidative stress induces senescence, or aging, in human fetal cells," said Dr. Ramkumar Menon, an assistant professor in the UTMB Department of Obstetrics and Gynecology and lead researcher on the study. "With more than 15 million pregnancies worldwide ending in preterm births, we can now move forward in discovering how this information may lead to better intervention strategies to reduce the risk of preterm birth."

Previous studies suggested that infection is the major cause of preterm premature rupture of the membranes (pPROM, or breaking of the water bag during pregnancy), for which antibiotics are standard intervention.

However, UTMB researchers discovered that interventions such as antibiotics and antioxidants have not been successful in preventing preterm deliveries. This study provides evidence that there are other factors out there that the medical community should look for when that are causing spontaneous births, said Menon.


'/>"/>

Contact: Kristen Hensley
k.hensley@utmb.edu
409-772-8772
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/9/2016)... -- Paris Police Prefecture ... to ensure the safety of people and operations in several ... tournament Teleste, an international technology group specialised in ... that its video security solution will be utilised by ... safety across the country. The system roll-out is scheduled for ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
Breaking Biology Technology: