Navigation Links
UTMB researchers create powerful new method to analyze genetic data
Date:6/12/2012

ndividuals and their genetic profiles simultaneously, and cognitively that's really important," Bhavnani said. "You can look at the individuals and know immediately which SNPs make them different from others, and conversely you can look at the SNPs to see how they are co-occurring, and with which individuals they are co-occurring. This rich representation enables you to quickly comprehend the complex bipartite relationships in the data"

The bipartite network visualization of the Utah-Nigeria individual-SNP data has distinct clusters on its left and right sides that correspond to the Utah and Nigerian subjects and SNPs. It also accurately portrays a genetic phenomenon called admixture, in which an individual possesses SNPs that are characteristic of individuals from Utah as well as from Nigeria. Admixed individuals are placed on the edges of their clusters, relatively close to the center of the visualization. The identification of admixed individuals, and the implicated SNPs could help in the design of case-control studies where there is a need for the selection of homogenous sets of individual from different ancestral origins.

To produce an even more detailed picture of the individual-SNP information, the researchers applied two other bipartite visualization techniques to the data: the bipartite heat map, and the bipartite Circos ideogram. In the heat map, rectangular cells laid out in a spreadsheet-like arrangement and colored white, gray, or black helped precisely define the boundaries of the clusters by clarifying individual-SNP relationships. In the Circos ideogram, individuals and SNPs placed around the perimeter of a circle and linked with curved lines, enabling the researchers to more closely examine the admixed individuals' ties to SNPs in the clusters associated with both Utah and Nigeria.

"The network representation is very powerful because it gives you the overall structure of the data, but to really understand the complex re
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... May 11, 2015  Synaptics Incorporated (NASDAQ: ... solutions, today announced the appointment of Wajid ... Financial Officer, reporting to Rick Bergman , ... Chief Financial Officer, Kathleen Bayless , who ... Mr. Ali brings extensive financial management expertise ...
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... manufacturers in China . The order value ... of + 1 000 MSEK for 2015.   Jörgen ...
(Date:5/6/2015)... May 6, 2015 LifeBEAM, a developer of ... producer, announced today that they will expand their partnership ... first bio-sensing cycling helmet and the first joint project ... new colors in order to give cyclists more style ... addition, LifeBEAM and Lazer announced their plan to release ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... may be onto an ocean of discovery because of his ... The research is likely to lead to making ceramics ... armour many times stronger. These findings were published in ... and focused on the mantis shrimp,s ability to shatter aquarium ...
... within the next five years and in ten years from ... today: what we are going to see at ESMO 2012 ... technologies can improve the tailoring of cancer therapies for the ... President More than 17,000 participants from over 120 different ...
... /PRNewswire-iReach/ -- FirstMark, the diagnostic division of ... Shah has joined its Scientific Advisory Board. ... Director of the Division of Cardiology. He also is ... Cedars-Sinai Medical Center where he leads several studies that ...
Cached Biology News:NTU researchers study little mighty creature for scientific breakthrough 2NTU researchers study little mighty creature for scientific breakthrough 3ESMO 2012 Congress: A path for medical oncology innovations 2ESMO 2012 Congress: A path for medical oncology innovations 3ESMO 2012 Congress: A path for medical oncology innovations 4FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisory Board 2FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisory Board 3
(Date:5/26/2015)... WORMS, GERMANY – May 26, ... GRA) announces that its manufacturing facility in Worms, ... from EXCiPACT™, an independent organization that certifies manufacturers, ... , All three Grace facilities that produce its ... gels have now received GMP certification, following the ...
(Date:5/26/2015)...   Intrexon Corporation (NYSE: XON ), a ... , Ph.D., Senior Vice President and Head of Intrexon,s Health ... on Wednesday, June 3 rd , at 1:30 p.m. Eastern ... City . About Intrexon Corporation ... Revolution with Better DNA ™ to create biologically-based products ...
(Date:5/26/2015)...   PDI , a leader in infection ... Healthcare in Dearborn, Mich. ... Delivering the Difference , a ... building collaborative relationships between infection prevention (IP) and ... Oakwood Healthcare,s infection preventionist, Priscila ...
(Date:5/26/2015)... May 26, 2015 Mr. Kevin Xu , ... President Barack Obama and President Bill Clinton ... of loss of Dr. Rongxiang Xu , Kevin,s father. ... leader ahead of his time, Dr. Xu,s commitment to the ... a legacy that will not be forgotten. As a renowned ...
Breaking Biology Technology:CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Intrexon to Present at the Jefferies 2015 Global Healthcare Conference 2PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3Dr. Rongxiang Xu, Beyond A Legend 2
... NeoStem Shareholders, We would like to take a ... for NeoStem (NYSE Amex: NBS ) – and to ... the company forward in 2012 and beyond. , We have ... LLC ("Amorcyte"). , We believe our therapeutic product development team ...
... LA JOLLA, Calif., Jan. 2, 2012 Renowned biochemist ... and CEO of The Scripps Research Institute January 1, ... for more than two decades. (Photo:  ... opportunity to advance the institute,s mission, creating knowledge in ...
... Dec. 28, 2011  MiMedx Group, Inc. (OTCBB: MDXG), ... protected regenerative biomaterials and bioimplants processed from human ... private placement offering to sell convertible notes and ... the offering, which commenced on October 15, 2011, ...
Cached Biology Technology:NeoStem's CEO Letter to Shareholders 2NeoStem's CEO Letter to Shareholders 3NeoStem's CEO Letter to Shareholders 4Michael A. Marletta Takes Office as New President of Scripps Research Institute 2MiMedx Group Completes $5,000,000 Private Placement 2MiMedx Group Completes $5,000,000 Private Placement 3
... Minis 150V power supply (Cat. No. Minis ... designed to meet most electrophoresis needs in ... The Minis 150V power supply is capable ... Supply is designed for individuals to have ...
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
... primers are designed for sequencing inserts cloned ... T7, or T3 RNA polymerase promoters, or ... supplied at a concentration of 0.1 µg/µl ... in DNA sequencing reactions using SequiTherm™ EXCEL™ ...
BD BioCoat Collagen I 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of rat tail collagen type I....
Biology Products: